Severe Neutropenia Associated With Griseofulvin Therapy in Cats With Feline Immunodeficiency Virus Infection     

Grady H. Shelton DVM    Chris K. Grant PhD  DSc    Michael L. Linenberger MD  Janis L. Abkowitz MD 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1990,4(6):317-319

Griseofulvin administration was associated with the development of absolute neutropenia in six of seven (86%) cats with feline immunodeficiency virus (FIV) infection. The neutropenia was severe (less than 400 neutrophils/microliter) in four of the six affected cats, and one cat died from sepsis. Neutrophil counts returned to baseline values within 15 days after drug withdrawal in all surviving cats. No symptoms or hematologic abnormalities were observed in four normal (FIV-seronegative) cats treated with the same lot of griseofulvin at equivalent doses. Neutropenia recurred in two of two FIV-seropositive cats upon griseofulvin rechallenge. Cats with FIV infections appear to be at increased risk for griseofulvin-associated neutropenia. This phenomenon may be analogous to the increased frequency of antibiotic-induced neutropenias observed in humans infected with the human immunodeficiency virus.  相似文献   

Esophageal Replacement in the Dog by Microvascular Colon Transfer     

ALAN B. KUZMA BSc  DVM  DVSc    DAVID L. HOLMBERG DVM  MVSc  DiplomateACVS    CRAIG W. MILLER DVM  MSc  DiplomateACVS    IAN BARKER DVM  MSc  PhD  JAMES ROTH MD  FRCS 《Veterinary surgery : VS》1990,18(6):439-445

An orthotopic colon graft based on the middle colic artery and vein was implanted with microvascular technique and a stapling instrument in five dogs. The grafts were successful in four dogs. A similar colon autograft was used to replace the entire thoracic esophagus in five dogs. The recipient vessels were the left carotid artery and left external jugular vein. Four of the grafts failed because of kinking and thrombosis of the arterial supply (2 dogs) or the venous outflow (2 dogs). One graft, which had a viable vascular supply, developed a severe leak at the colon-to-stomach anastomosis, and the dog was euthanatized on day 3. The recipient vascular pedicle was modified and used successfully to replace a portion of the cervical esophagus in three dogs. The grafts survived, the dogs could swallow liquids and semisolid food well, and, at necropsy after 4 weeks, the anastomotic sites were well healed. The graft sites contained essentially normal colon mucosa.  相似文献   

A QUANTITATIVE CIRCULATION SCHEME     

Porter WT 《Science (New York, N.Y.)》1905,21(541):752-753

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THE FLOW OF THE CONNECTICUT RIVER     

Porter D 《Science (New York, N.Y.)》1896,3(68):579-582

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ARE PLANETS RARE?     

Porter JG 《Science (New York, N.Y.)》1930,72(1859):170

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The use of ethylene chlorohydrin for breaking the rest period of large quantities of potatoes     

W. F. Porter  G. W. Simpson 《American Journal of Potato Research》1947,24(1):9-14

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Evaluation of Serum Phosphorylated Neurofilament Subunit NF‐H as a Prognostic Biomarker in Dogs With Thoracolumbar Intervertebral Disc Herniation     

Hidetaka Nishida DVM  PhD  Masanari Nakayama DVM  PhD  Hiroshi Tanaka DVM  PhD  Hiroaki Kamishina DVM  PhD  Takeshi Izawa DVM  PhD  Shingo Hatoya DVM  PhD  Kikuya Sugiura DVM  PhD  Yoshihisa Suzuki MD  PhD  Chizuka Ide MD  PhD  Toshio Inaba DVM  PhD 《Veterinary surgery : VS》2014,43(3):289-293

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Coil Embolization of a Palatine Artery Pseudoaneurysm in a Gelding     

Nathaniel R. McClellan DVM  Margaret C. Mudge VMD  Diplomate ACVS  ACVECC  Brian A. Scansen DVM  MS  Diplomate ACVIM  Stephen S. Jung MD  FACR  Duncan Russell BVMS  Diplomate ACVP 《Veterinary surgery : VS》2014,43(4):487-494

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New Concepts in Standing Advanced Diagnostic Equine Imaging     

Erin G. Porter  Natasha M. Werpy  DVM 《Veterinary Clinics of North America: Equine Practice》2014

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Necrotizing Meningoencephalitis in Atypical Dog Breeds: A Case Series and Literature Review     

J.J. Cooper  S.J. Schatzberg  K.M. Vernau  B.A. Summers  B.F. Porter  S. Siso  B.D. Young  J.M. Levine 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2014,28(1):198-203

Background

Canine necrotizing meningoencephalitis (NME) is a fatal, noninfectious inflammatory disease of unknown etiology. NME has been reported only in a small number of dog breeds, which has led to the presumption that it is a breed‐restricted disorder.

Hypothesis/Objectives

Our objective was to describe histopathologically confirmed NME in dog breeds in which the condition has not been reported previously and to provide preliminary evidence that NME affects a wider spectrum of dog breeds than previously reported.

Animals

Four dogs with NME.

Methods

Archives from 3 institutions and from 1 author''s (BS) collection were reviewed to identify histopathologically confirmed cases of NME in breeds in which the disease has not been reported previously. Age, sex, breed, survival from onset of clinical signs, and histopathologic findings were evaluated.

Results

Necrotizing meningoencephalitis was identified in 4 small dog breeds (Papillon, Shih Tzu, Coton de Tulear, and Brussels Griffon). Median age at clinical evaluation was 2.5 years. Histopathologic abnormalities included 2 or more of the following: lymphoplasmacytic or histiocytic meningoencephalitis or encephalitis, moderate‐to‐severe cerebrocortical necrosis, variable involvement of other anatomic locations within the brain (cerebellum, brainstem), and absence of detectable infectious agents.

Conclusions and Clinical Importance

Until now, NME has only been described in 5 small dog breeds. We document an additional 4 small breeds previously not shown to develop NME. Our cases further illustrate that NME is not a breed‐restricted disorder and should be considered in the differential diagnosis for dogs with signalment and clinical signs consistent with inflammatory brain disease.  相似文献