Pharmacokinetics and safety of single and multiple oral doses of meloxicam in adult horses     

G Noble  S Edwards  J Lievaart  J Pippia  R Boston  SL Raidal 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2012,26(5):1192-1201

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Necrotising ventriculitis due to combined infection with Rhizopus microsporus var. chinensis and Candida krusei in an eclectus parrot (Eclectus roratus)     

Muir M  Raidal SR 《Australian veterinary journal》2012,90(7):277-280

Acute necrosis of the ventriculus is a very uncommon lesion in birds. We describe a fatal case of acute necrotising ventriculitis caused by Rhizopus microsporus var. chinensis in a mature female eclectus parrot (Eclectus roratus). The bird presented acutely dull and lethargic, was vomiting and had bright green droppings, suggestive of acute heavy metal poisoning. It was treated with fluids and chelation therapy, but died within 12 h. Necropsy, cytology, histopathology and culture results demonstrated fungal invasion of the ventriculus associated with transmural necrosis, haemorrhage, acute inflammation and abundant R. microsporus var. chinensis and lesser numbers of Candida krusei.  相似文献   

Haematopoietic necrosis in a goldfish (Carassius auratus) associated with an agent morphologically similar to herpesvirus   总被引：1，自引：0，他引：1  

Stephens FJ  Raidal SR  Jones B 《Australian veterinary journal》2004,82(3):167-169

One of 14 goldfish (Carassius auratus) died 4 weeks after purchase and was investigated by necropsy and histological examination. Routine formalin fixation of the goldfish was followed by histopathology. Formalin fixed spleen and kidney from the fish was further processed by embedding in epoxy resin and examined by transmission electron microscopy (EM). Severe, diffuse necrosis of haematopoietic tissue in the spleen, thymus and kidney and severe, diffuse hyperplasia in the gill epithelial cells were seen. In the spleen there was severe, diffuse necrosis of lymphocytes and many nuclei with marginated chromatin and intranuclear inclusions were scattered throughout the necrotic tissue. EM of affected tissues demonstrated intranuclear particles morphologically similar to herpesvirus. The presence of an agent similar to a herpesvirus in a goldfish with severe haematopoietic necrosis suggests that the herpesvirus responsible for haematopoietic necrosis in cyprinid species throughout the world has entered the goldfish population in Australia.  相似文献   

Knemidocoptes intermedius in a wild currawong (Strepera graculina)   总被引：1，自引：0，他引：1  

Jaensch SM  Raidal SR  Hobbs R 《Australian veterinary journal》2003,81(7):411-411

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Mycobacteriosis in gang gang cockatoos (Callocephalon fimbriatum).     

Stacey Gelis  James H Gill  Tim Oldfield  Susan M Jaensch  Shane R Raidal 《Veterinary Clinics of North America: Exotic Animal Practice》2006,9(3):487-494

This report presents three cases of mycobacteriosis in gang gang cockatoos (Callocephalon fimbriatum) that highlight the potential variation in clinical presentation of this important avian disease. The first case was a female gang gang cockatoo with widespread skeletal disease that presented with a chronic history of weight loss and nonpainful, bilaterally symmetric, distal-wing and leg nodular swellings. The second case was a mature female in good muscle condition with a nodular granulomatous pericarditis and myocarditis causing severe hydropericardium and cardiac tamponade; it was presented for respiratory distress. The third case was one of alimentary mycobacteriosis that presented with a chronic history of weight loss. Some difficulties associated with confirming a premortem diagnosis of mycobacteriosis are discussed.  相似文献   

The effect of high intensity exercise on the functional capacity of equine pulmonary alveolar macrophages and BAL-derived lymphocytes     

Raidal SL  Love DN  Bailey GD  Rose RJ 《Research in veterinary science》2000,68(3):249-253

The effect of strenuous exercise on the functional capacity of pulmonary alveolar macrophages (PAM) and bronchoalveolar lavage-derived lymphocytes was determined in eight horses prior to and after 7 weeks of training. Strenuous exercise had no effect on the total cell count or the percentage of live cells in bronchoalveolar lavage (BAL) samples prior to or following training. However, training was associated with a significant increase in the total cell count of pre-exercise BAL samples and a significant reduction in the percentage of live cells in post-exercise samples. Strenuous exercise was associated with impaired phagocytosis by PAM after 7 weeks of training but had no effect on similar samples obtained from untrained horses. The oxidative burst activity of PAM was significantly increased following strenuous exercise for both untrained and trained horses. BAL -derived lymphocyte oxidative burst was similarly affected following training. These results suggest that strenuous exercise and training may influence pulmonary immune cell function.  相似文献   

Antimicrobial stewardship in equine practice     

SL Raidal 《Australian veterinary journal》2019,97(7):238-242

Antimicrobial stewardship involves the judicious use of antimicrobials balanced against the requirement to treat the presenting clinical condition. The same mandate and principles as discussed in human medicine and other veterinary disciplines are relevant to equine practice. This brief review will focus on available resources for equine practitioners, emerging perspectives on antimicrobial use and stewardship, and opportunities for more effective antimicrobial use in equine practice. There is a need for improved client education, availability of faster and more accurate techniques for identification and sensitivity testing of bacterial pathogens, and the development of novel agents.  相似文献   

Genome sequence of an Australian strain of canid alphaherpesvirus 1          下载免费PDF全文

S Sarker  S Das  K Helbig  A Peters  SR Raidal 《Australian veterinary journal》2018,96(1-2):24-27

Objective

Characterisation of a complete genome sequence of an Australian strain of canid alphaherpesvirus 1 (CHV‐1) and its phylogenetic relationship with other varicellovirus species.

Methods

Standard pathology and PCR methods were used to initially detect herpesvirus in hepatic tissue from an infected 4‐week‐old Labrador Retriever puppy. The complete CHV‐1 genome was sequenced using next‐generation sequencing technology followed by de novo and reference assembly, and genome annotation.

Results

The CHV‐1 genome was 125 kbp in length and contained 74 predicted open reading frames encoding functional proteins, all of which have counterparts in other alphaherpesviruses. Phylogenetic analysis using the DNA polymerase gene revealed that the newly sequenced CHV‐1 clustered with canid alphaherpesvirus isolated from the UK and shared a 99% overall nucleotide sequence similarity.

Conclusion

This is the first complete genome of an Australian strain of CHV‐1, which will contribute to our understanding of the genetics and evolution of herpesvirus.  相似文献   

Ultrasonography to investigate the effect of supplementing whole milk with complex carbohydrates and specific amino acids on curd retention in the abomasum of dairy calves     

K Singh  SR Leath  HV Henderson  TJ Watson  D Pacheco 《New Zealand veterinary journal》2016,64(5):288-292

AIM: To determine whether the retention time of curd in the abomasum of calves was influenced by supplementing milk with a plant-derived carbohydrate and amino acid supplement, evaluated non-invasively using ultrasonography.

METHODS: Female dairy calves aged between 2–6 days of age were sourced from a commercial farm in March 2013. All calves were fed whole milk until weaning (4?L per day); 21 calves were supplemented with a probiotic until 18 days of age, and thereafter with a plant-derived complex carbohydrate and amino acid supplement until weaning, and 22 calves were just fed whole milk. Treatment groups were balanced for age, weight and breed. At 9–14, 24–29 and 52–57 days of age, the abomasum of each calf was examined using ultrasonography immediately before and after feeding, 1 and 2 hours after feeding, and then at 30 minute intervals until curd was no longer visible in the abomasum. Abomasal volume and curd size were recorded to assess retention time of curd in the abomasum.

RESULTS: At 9–14 days of age, mean retention time of curd in the abomasum was similar (4.6 hours) in both groups. At 24–29 days of age, when the supplemented calves had been receiving the supplement for approximately 10 days, mean curd retention time was longer by 1.4 (SE 0.28) hours in supplemented compared with unsupplemented calves (p<0.001). At 52–57 days of age, mean retention time was longer by 0.7 (SE 0.34) hours compared to unsupplemented calves (p=0.05).

CONCLUSION: Using ultrasonography, changes in abomasal content could be followed non-invasively over time and it was demonstrated that the plant-derived complex carbohydrate supplement increased the curd retention time in the abomasum. We speculate that the increased retention time enables an increased availability of nutrients following a more complete digestion of milk, thereby improving animal performance.  相似文献   

Successful management of multiple extrapulmonary complications associated with Rhodococcus equi pneumonia in a foal          下载免费PDF全文

E. J. A. Wilkes  K. J. Hughes  A. E. Kessell  S. L. Raidal 《Equine Veterinary Education》2016,28(4):186-192

This report describes the diagnosis and successful treatment of multiple extrapulmonary sequelae of Rhodococcus equi (R. equi) pneumonia in a 3‐month‐old filly. Bilateral uveitis and hyphaema, haemolytic anaemia and polysynovitis developed in this foal and were likely due to immune‐mediated mechanisms. The challenges associated with diagnosis and treatments of these extrapulmonary disorders are discussed. The filly was treated initially with clarithromycin and rifampin; however, a blood transfusion and immunosuppressive therapy with dexamethasone were required due to progressive haemolysis and for treatment of uveitis and polysynovitis. Bilateral hyphaema was successfully treated with intracameral injections of a recombinant tissue plasminogen activator. The development of antimicrobial resistance in R. equi was an additional challenge encountered in the management of this case and emphasises the importance of culture and in vitro antimicrobial susceptibility testing of isolates from foals with R. equi pneumonia. Extrapulmonary disorders associated with R. equi pneumonia are likely underdiagnosed and associated with a poor prognosis. This case highlights the importance of thorough and ongoing diagnostic assessment of foals with R. equi pneumonia and demonstrates that a successful outcome can be achieved with appropriate and directed treatment.  相似文献