Rabacfosadine for relapsed canine B‐cell lymphoma: Efficacy and adverse event profiles of 2 different doses          下载免费PDF全文

C. F. Saba  K. R. Vickery  C. A. Clifford  K. E. Burgess  B. Phillips  D. M. Vail  Z. M. Wright  M. A. Morges  T. M. Fan  D. H. Thamm 《Veterinary and comparative oncology》2018,16(1):E76-E82

Rabacfosadine (RAB), a novel double prodrug of the acyclic nucleotide phosphonate PMEG, preferentially targets neoplastic lymphocytes with reduced off target toxicity. Historical studies have suggested that every 21‐day dosing is effective with acceptable toxicity. The purpose of this study was to evaluate RAB’s safety and efficacy at 2 different doses every 21 days in dogs with relapsed B‐cell lymphoma. Dogs that had failed 1 doxorubicin‐based chemotherapy protocol were eligible for inclusion in this prospective trial. Once enrolled, dogs were randomized to receive RAB at either 0.82 mg/kg or 1.0 mg/kg as a 30‐minute IV infusion every 21 days for up to 5 treatments. Response assessment and adverse event (AE) evaluation were performed every 21 days via VCOG criteria. Fifty dogs were enrolled, with 16 treated at 0.82 mg/kg and 34 treated at 1.0 mg/kg. The overall response rate was 74%, with 45% of dogs experiencing a complete response (CR). The median progression free intervals (PFIs) were 108 days, 172 days and 203 days for all dogs, all responders, and all CRs, respectively. Response rates and PFIs were similar in both treatment groups. The incidence of AEs, dose delays, dose reductions and withdrawals were not statistically different between the 2 groups. The AEs observed were similar to those previously reported and included hematologic, gastrointestinal, dermatologic and pulmonary AEs. One dog had grade 5 pulmonary fibrosis; otherwise, AEs resolved with supportive treatment. Rabacfosadine is a generally well tolerated, effective chemotherapy option for dogs with relapsed B‐cell lymphoma.  相似文献   

Quantitative and thematic analysis of complaints by clients against clinical veterinary practitioners in New Zealand     

SJG Gordon  DH Gardner  JF Weston  CF Bolwell  J Benschop  TJ Parkinson 《New Zealand veterinary journal》2019,67(3):117-125

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Alternating rabacfosadine and doxorubicin for treatment of naïve canine lymphoma     

Corey F. Saba  Timothy M. Fan  Brenda S. Phillips  Zachary M. Wright  Douglas H. Thamm 《Veterinary and comparative oncology》2024,22(2):278-283

The current standard of care treatment for canine lymphoma is a multi-agent, CHOP-based chemotherapy protocol. Single agent doxorubicin (DOX) is less burdensome; however, multi-agent chemotherapy protocols are often superior. The recently approved drug rabacfosadine (RAB, Tanovea) provides an attractive option for combination therapy with DOX, as both drugs demonstrate efficacy against lymphoma and possess different mechanisms of action. A previous study evaluating alternating RAB/DOX reported an overall response rate (ORR) of 84%, with a median progression-free survival time (PFS) of 194 days. The aim of this prospective trial was to evaluate the same protocol in an additional population of dogs. Fifty-nine dogs with treatment naïve lymphoma were enrolled. RAB (1.0 mg/kg IV) was alternated with DOX (30 mg/m² IV) every 21 days for up to six total treatments (3 cycles). Response assessment and adverse event (AE) evaluation were performed every 21 days using VCOG criteria. The ORR was 93% (79% CR, 14% PR). The median time to maximal response was 21.5 days; median PFS was 199 days. T cell immunophenotype and lack of treatment response were predictive of inferior outcomes. AEs were mostly gastrointestinal. Six dogs developed presumed or confirmed pulmonary fibrosis; four were grade 5. One dog experienced grade 3 extravasation injury with RAB that resolved with supportive treatment. These data mirror those of the previously reported RAB/DOX study, and support the finding that alternating RAB/DOX is a reasonable treatment option for canine lymphoma.  相似文献   

Multiple-step melting in two-dimensional hexatic liquid-crystal films     

CF Chou  AJ Jin  SW Hui  CC Huang  JT Ho 《Science (New York, N.Y.)》1998,280(5368):1424-1426

An unexpected three-stage melting transition has been observed in two-dimensional (2D) free-standing liquid-crystal films by in situ electron-diffraction and optical-reflectivity measurements. These data suggest the existence of two phases between the 2D solid and liquid: a hexatic phase and, at a higher temperature, an intermediate liquid phase with hexatic-like positional correlations ( approximately 40 angstroms) but no long-range orientational order. Previous high-resolution heat-capacity measurements have revealed a divergent-like anomaly at the hexatic-liquid transition that sharply contradicts the predictions of 2D melting theories. The observation of an intermediate isotropic phase may alter our understanding of 2D melting and lead to reconciliation between current experiments and theories.  相似文献   

Dexrazoxane treatment of doxorubicin extravasation injury in four dogs     

Venable RO  Saba CF  Endicott MM  Northrup NC 《Journal of the American Veterinary Medical Association》2012,240(3):304-307

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Cryoprecipitate reversal of opsonic alpha2-surface binding glycoprotein deficiency in septic surgical and trauma patients   总被引：13，自引：0，他引：13  

T M Saba  F A Blumenstock  W A Scovill  H Bernard 《Science (New York, N.Y.)》1978,201(4356):622-624

Human opsonic alpha2-surface binding glyoprotein (alphs2SB-glycoprotein), a molecule having immunologic identity with an amino acid composition similar to cold-insoluble globulin, is concentrated in a cryoprecipitate of plasma. Septic surgical and trauma patients manifesting opsonic alpha2SB-glycoprotein deficiency and associated reticuloendothelial system dysfunction were treated by intravenous infusion of cryoprecipitate. This therapy restored circulating bioreactive and immunoreactive opsonin and improved their septicemia, pulmonary insufficiency, and duration of recovery. Cryoprecipitate infusion may offer a new approach to the treatment of septic injured patients in preventing multiple organ failure; measurement of immuno-reactive serum opsonic alpha2SB-glycoprotein may provide a noninvasive index of reticuloendothelial system function and patient status during servere sepsis that follows trauma.  相似文献   

Application of Wastewater Irrigation on Growth and Yield of Chilli Under Nitrogen and Phosphorus Fertilization     

Shaista Chalkoo  Arif Inam  Saba Iqbal 《Journal of plant nutrition》2014,37(7):1139-1147

In the present study a pot experiment was carried out in 2009 where different nitrogen (N) and phosphorus (P) combinations with soil (N₀P₀, N₂₀P₃₀, N₂₀P₆₀, N₄₀P₃₀, and N₄₀P₆₀) were taken into pots. Nutritional growth and yield such as length, fresh and dry weight, leaf area, leaf number, pedicle length, fruit length, fruit number, and seed content were significant at P?≤?0.05. Evaluation of data reveals that plant growth parameters and yield of chilli significantly increased in wastewater treatment with 20 kg ha^?1 N and 30 kg ha^?1 P in comparison to groundwater treatments. It was also found that higher dose of fertilizers with wastewater decreases plant growth and development of Capsicum annuum L. Thus it was concluded that wastewater reuse as a source of nutrient may not only solves the problems of the more use of chemical fertilizers but also decreases the fresh water scarcity in agriculture land.  相似文献   

Assessment of urea coated with pomegranate fruit powder as N slow-release fertilizer in maize     

Hossein Sabahi  Saba Siadat Jamian  Fahimeh Ghashghaee 《Journal of plant nutrition》2016,39(14):2092-2099

It has been hypothesized that plant polyphenol plus lignin, cellulose, and hemicelluloses can immobilize/remineralize inorganic fertilizers, such as urea, better than polyphenol alone. To test this hypothesis, urea was coated with pomegranate (Punica granatum L.) fruit powder (containing polyphenol+lignin+cellulose) at rates of 0%, 30%, 70%, and 100% (w/w) of fertilizer urea. Fertilizer nitrogen was applied at 100 and 200 mg kg^?1 soil in a clay loam soil. This natural coating material, particularly at the rate of 100% (w/w), improved the distribution of mineral nitrogen (N) and available phosphorus (P) in soil during both early and advanced growth stages of maize and significantly increased total crop N and P uptake at both rates of fertilizer nitrogen compared to urea alone. The results suggest that urea coated with the powder of pomegranate fruit could potentially be an N slow-release fertilizer for use in better synchronizing crop N demand with soil N supply.  相似文献   

Consumers’ beliefs about whole and refined grain products in the UK, Italy and Finland   总被引：2，自引：1，他引：2  

A. Arvola  L. Lhteenmki  M. Dean  M. Vassallo  M. Winkelmann  E. Claupein  A. Saba  R. Shepherd 《Journal of Cereal Science》2007,46(3):197-206

The objective of this study was to increase our understanding of consumers’ product related expectations that may influence their willingness to use whole grain (WG) foods. Consumers’ beliefs about WG and refined grain (RG) product categories were measured, compared and consumers were segmented based on these beliefs. Data were collected with self-completion questionnaires in the UK (N=552), Italy (N=504), and Finland (N=513).On average, consumers in Finland, Italy and the UK were aware that WG products are healthier than RG products as the WG product category was rated as more nutritionally balanced, healthier, more natural, more filling, releasing energy more slowly and slightly more digestible than the RG product category. However, certain consumer segments did not perceive much difference between whole and RG products in their health-related characteristics suggesting a lack of motivation for increasing WG consumption. This sets a challenge for promoting WG products especially in Italy and the UK, where the respondents were less likely to differentiate between the healthiness of WG and RG products than the Finnish respondents. Differences between the consumer segments and ways of promoting WG consumption are discussed.  相似文献   

Kopulationsfrequenz,Giftempfindlichkeit und Heterogenität von Weibchen und Männchen beiTetranychus urticae Koch     

F. Saba 《Journal of pest science》1962,35(9):141-142

Zusammenfassung 10 Tage alte, jungfräuliche Weibchen vonTetranychus urticae Koch können noch begattet und ihre Eier befruchtet werden; einzelne Männchen konnten bis zu 7 Weibchen im Verlauf von 8 Tagen begatten. Weibchen erwiesen sich als 20mal so giftwiderstandsfähig wie Männchen; beide Geschlechter besaßen gleiche Heterogenität in der Population.

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Summary 10 days old unfertilized females ofTetranychus urticae Koch may become fertilized and deposite fertile eggs; within 8 days single males were able to fertilise up to 7 females; females were found to be 20 times more resistent to poison than males; within the population both sexes were of the same heterogenity.

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Résumé Des femelles virginales de 10 jours deTetranychus urticae Koch peuvent encore être accouplées et ses oeufs peuvent être fécondés. Quelques mâles pouvaint s'accoupler avec jusqu'à sept femelles au cours de huit jours. Les femelles se montraient vingt fois plus résistentes à poison que les mâles; dans la population les deux sexes avaient la même hétérogénéité.

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