A 6-year-old Rottweiler with weight loss     

P. CLARK  CL SWENSON  CM DRENEN 《Australian veterinary journal》1997,75(10):709-709

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Unusual osteochondral lesions of the talus in a horse     

CM SIMPSON  JM LUMSDEN 《Australian veterinary journal》2001,79(11):752-755

A 2-year-old Thoroughbred gelding was evaluated for a grade 3 out of 5 unilateral hind limb lameness. Flexion of the right hock and stifle joints (spavin test) exacerbated the lameness. Response to intra-articular and perineural anaesthesia isolated the source of lameness to the tarsocrural area, despite an absence of tarsocrural joint effusion. Routine radiographic examination of the hock did not reveal any significant abnormalities. Skeletal nuclear scintigraphic evaluation revealed a focal region of increased bone activity in the proximal medial trochlear ridge of the talus. Flexed lateromedial radiographic views identified three discrete semicircular lytic lesions at the proximal articular margin of the medial trochlear ridge of the talus. Conservative management of the lesions was associated with a successful return to racing. The location and appearance of the osteochondral lesions of this report have not been previously reported and may be a manifestation of developmental orthopaedic disease and abnormal endochondral ossification. Nuclear scintigraphy and flexed lateromedial radiographic views facilitated identification of the lesions. This radiographic view is recommended when lameness is isolated to the tarsocrural joint and standard radio-graphic projections fail to identify a cause.  相似文献   

Surgical correction of anorectal atresia and rectovaginal fistula in an alpaca cria     

DB CARRARO  AJ DART  NPH HUDSON  CM DART  DR HODGSON 《Australian veterinary journal》1996,74(5):352-354

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Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus   总被引：92，自引：0，他引：92  

H Kestler  T Kodama  D Ringler  M Marthas  N Pedersen  A Lackner  D Regier  P Sehgal  M Daniel  N King 《Science (New York, N.Y.)》1990,248(4959):1109-1112

Better understanding of the pathogenesis of acquired immunodeficiency syndrome (AIDS) would be greatly facilitated by a relevant animal model that uses molecularly cloned virus of defined sequence to induce the disease. Such a system would also be of great value for AIDS vaccine research. An infectious molecular clone of simian immunodeficiency virus (SIV) was identified that induces AIDS in common rhesus monkeys in a time frame suitable for laboratory investigation. These results provide another strong link in the chain of evidence for the viral etiology of AIDS. More importantly, they define a system for molecular dissection of the determinants of AIDS pathogenesis.  相似文献   

Human beta 2 interferon and B-cell differentiation factor BSF-2 are identical   总被引：23，自引：0，他引：23  

P B Sehgal  L T May  I Tamm  J Vilcek 《Science (New York, N.Y.)》1987,235(4790):731-732

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High-Pressure Iron-Sulfur Compound, Fe3S2, and Melting Relations in the Fe-FeS System     

Y Fei  CM Bertka  LW Finger 《Science (New York, N.Y.)》1997,275(5306):1621-1623

An iron-sulfur compound (Fe3S2) was synthesized at pressures greater than 14 gigapascals in the system Fe-FeS. The formation of Fe3S2 changed the melting relations from a simple binary eutectic system to a binary system with an intermediate compound that melted incongruently. The eutectic temperature in the system at 14 gigapascals was about 400°C lower than that extrapolated from Usselman's data, implying that previous thermal models of Fe-rich planetary cores could overestimate core temperature. If it is found in a meteorite, the Fe3S2 phase could also be used to infer the minimum size of a parent body.  相似文献   

A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK     

Williams JA  Su HS  Bernards A  Field J  Sehgal A 《Science (New York, N.Y.)》2001,293(5538):2251-2256

Output from the circadian clock controls rhythmic behavior through poorly understood mechanisms. In Drosophila, null mutations of the neurofibromatosis-1 (Nf1) gene produce abnormalities of circadian rhythms in locomotor activity. Mutant flies show normal oscillations of the clock genes period (per) and timeless (tim) and of their corresponding proteins, but altered oscillations and levels of a clock-controlled reporter. Mitogen-activated protein kinase (MAPK) activity is increased in Nf1 mutants, and the circadian phenotype is rescued by loss-of-function mutations in the Ras/MAPK pathway. Thus, Nf1 signals through Ras/MAPK in Drosophila. Immunohistochemical staining revealed a circadian oscillation of phospho-MAPK in the vicinity of nerve terminals containing pigment-dispersing factor (PDF), a secreted output from clock cells, suggesting a coupling of PDF to Ras/MAPK signaling.  相似文献   

Synthesis of Novel Thin-Film Materials by Pulsed Laser Deposition     

DH Lowndes  DB Geohegan  AA Puretzky  DP Norton  CM Rouleau 《Science (New York, N.Y.)》1996,273(5277):898-903

Pulsed laser deposition (PLD) is a conceptually and experimentally simple yet highly versatile tool for thin-film and multilayer research. Its advantages for the film growth of oxides and other chemically complex materials include stoichiometric transfer, growth from an energetic beam, reactive deposition, and inherent simplicity for the growth of multilayered structures. With the use of PLD, artificially layered materials and metastable phases have been created and their properties varied by control of the layer thicknesses. In situ monitoring techniques have provided information about the role of energetic species in the formation of ultrahard phases and in the doping of semiconductors. Cluster-assembled nanocrystalline and composite films offer opportunities to control and produce new combinations of properties with PLD.  相似文献   

Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III   总被引：74，自引：0，他引：74  

N L Letvin  M D Daniel  P K Sehgal  R C Desrosiers  R D Hunt  L M Waldron  J J MacKey  D K Schmidt  L V Chalifoux  N W King 《Science (New York, N.Y.)》1985,230(4721):71-73

The T-cell tropic retrovirus of macaque monkeys STLV-III has morphologic, growth, and antigenic properties indicating that it is related to HTLV-III/LAV, the etiologic agent of the acquired immune deficiency syndrome (AIDS) in humans. Four of six rhesus monkeys died within 160 days of STLV-III inoculation with a wasting syndrome, opportunistic infections, a primary retroviral encephalitis, and immunologic abnormalities including a decrease in T4+ peripheral blood lymphocytes. These data show that an immunodeficiency syndrome can be produced experimentally in a nonhuman primate by an agent from the HTLV-III/LAV group of retroviruses. The STLV-III-macaque system will thus provide a useful model for the study of antiviral agents and vaccine development for human AIDS.  相似文献   

Significance for exercise capacity of some electrocardiographic findings in racehorses     

CM KING  DL EVANS†  RJ ROSE 《Australian veterinary journal》1994,71(7):200-202

Summary Various cardiorespiratory and metabolic indices were assessed during treadmill exercise in Thoroughbred and Standardbred racehorses with T wave changes in 4 or more leads on the electrocardiogram or second-degree atrio-ventricular (AV) block, and in horses that had no abnormalities on clinical examination, resting electrocardiography or upper respiratory tract endoscopy. No significant differences in heart rate, plasma lactate concentration, arterial blood gases, oxygen uptake, run time, peak velocity, or blood and red cell volumes were found between normal horses and horses with T wave changes or second-degree AV block. These results indicate that some electrocardiographic findings that are considered by some clinicians to indicate cardiac dysfunction, may have little effect on exercise capacity.  相似文献