Naringin-loaded Poly(ε-caprolactone)/Gelatin Electrospun Mat as a Potential Wound Dressing: In vitro and In vivo Evaluation     

Majid Salehi  Ahmad Vaez  Mahdi Naseri-Nosar  Saeed Farzamfar  Arman Ai  Jafar Ai  Shima Tavakol  Mehrdad Khakbiz  Somayeh Ebrahimi-Barough 《Fibers and Polymers》2018,19(1):125-134

In the present study, naringin, a flavonoid isolated from the grape and citrus fruit species, was incorporated with poly(ε-caprolactone)/gelatin composite mats in order to develop a potential wound dressing. The composite mats were prepared by electrospinning of poly(ε-caprolactone)/gelatin (1:1 (w/w)) solution incorporated with 1.50 %, 3 % and 6 % (w/w) of naringin. The electrospun mats were evaluated regarding their morphology, contact angle, water-uptake capacity, water vapor transmission rate, tensile properties, drug release, cellular response and in vivo wound healing activity. The study showed that after 2 weeks, the full-thickness excisional wounds of Wistar rats treated with the naringin-loaded dressings achieved a wound closure of higher than 94 % and the dressing containing 6 % (w/w) naringin had almost 100 % wound closure. The sterile gauze, as the control group, showed nearly 86 % of wound closure after this period of time. Our results provided evidence that supports the possible applicability of naringin-loaded wound dressing for successful wound treatment.  相似文献   

An improved shear lag model for predicting stress distribution in hybrid fiber reinforced rubber composites     

Bin Zhang  Xiaoming Yu  Boqin Gu 《Fibers and Polymers》2017,18(2):349-356

An improved micromechanical shear lag model, which considers the interphase and bonded fiber end, is developed to investigate the load-carrying characteristics and stress profiles in hybrid aramid/sepiolite fiber reinforced rubber composites. The properties of the equivalent matrix, which is combination of sepiolite fiber and rubber matrix, are determined by Mori-Tanaka method. The axial and shear stresses at the fiber end are resolved by the imaginary fiber technique. The results obtained from the improved model show the tensile stress has a maximal at the real fiber center and the interfacial shear stress has a maximal at the end of the real fiber. Comparing with the results from Tsai’s model, the improved model has a better agreement with the numerical simualtion results. The effects of the imaginary fiber length on the stress transfer are analyzed and the results show that the effects can be ignored when the imaginary fiber length is greater than twice of the fiber radius. The effects of interphase modulus and thickness on the maximal axial and shear stresses are discussed. The results show that the interphase modulus and thickness of about 106.3 MPa and 0.2 μm are optimal to prevent interfacial debonding and improve the strength of hybrid fiber reinforced rubber composites.  相似文献   

Todd LeVasseur,Pramod Parajuli and Norman Wirzba (eds.): Religion and sustainable agriculture: world spiritual traditions and food ethics     

Christian Kelly Scott 《Agriculture and Human Values》2018,35(2):537-538

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An Electrothermochromic Fabric Prepared by Electrodeposition of Polypyrrole on Single Side     

Zeqi Chen  Chengzhuo Wei  Weida Rao  Lingling Fan  Jie Xu 《Fibers and Polymers》2018,19(11):2344-2350

An electrothermochromic fabric triggered by electric voltages was prepared by combining the electric heating feature of conductive polypyrrole (PPy) and the temperature-response color-changing feature of thermochromic inks. PPy was deposited selectively on the carbon-coated side of the sailcloth fabric via electrochemical polymerization. Thermochromic inks were painted on the reverse side with white color. The obtained fabric could be heated to about 48 °C and change its color significantly under an applied voltage of 3 V.  相似文献   

Bioinformatics resources for deciphering the biogenesis and action pathways of plant small RNAs     

Dongliang Yu  Xiaoxia Ma  Ziwei Zuo  Weishan Shao  Huizhong Wang  Yijun Meng 《Rice》2017,10(1):38

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Erratum to: Population genetic analysis of hyacinth bean (<Emphasis Type="Italic">Lablab purpureus</Emphasis> (L.) Sweet,Leguminosae) indicates an East African origin and variation in drought tolerance     

Oliver Robotham  Mark Chapman 《Genetic Resources and Crop Evolution》2017,64(2):441-441

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A proposal of clinical breakpoints for amoxicillin applicable to porcine respiratory tract pathogens     

Schwarz S  Böttner A  Goossens L  Goosens L  Hafez HM  Hartmann K  Kaske M  Kehrenberg C  Kietzmann M  Klarmann D  Klein G  Krabisch P  Luhofer G  Richter A  Schulz B  Sigge C  Waldmann KH  Wallmann J  Werckenthin C 《Veterinary microbiology》2008,126(1-3):178-188

In the present position paper, an attempt was made to establish clinical breakpoints of amoxicillin to classify porcine respiratory tract pathogens as susceptible, intermediate or resistant based on their minimum inhibitory concentrations of amoxicillin. For this, a thorough review of the published literature with regard to swine-specific pharmacological data (including dosages of amoxicillin applied and routes of administration used), clinical efficacy, and in vitro susceptibility of the target pathogens was performed. Based on the comparative analysis of the results, the working group "Antibiotic Resistance" of the German Veterinary Medical Society (DVG) proposed to classify porcine respiratory tract pathogens that show MIC values of amoxicillin of < or =0.5microg/ml as "susceptible", those with MICs of 1microg/ml as "intermediate", and those with MICs of > or =2microg/ml as "resistant".  相似文献   

Association of Treponema spp. with canine periodontitis     

Nordhoff M  Rühe B  Kellermeier C  Moter A  Schmitz R  Brunnberg L  Wieler LH 《Veterinary microbiology》2008,127(3-4):334-342

To evaluate the association of oral Treponema (T.) spp. with severity of canine periodontitis, subgingival plaque samples of dogs of various breeds undergoing surgery were investigated. A wide range of oral Treponema spp. was analysed by a molecular and culture-independent approach applying DNA-DNA dot blot hybridization analysis and fluorescence in situ hybridization using Treponema specific oligonucleotide probes specific for phylogenetic groups I-VII of oral treponemes as well as probes specific for T. socranskii and T. denticola. To assess the periodontal status of affected dogs clinical parameters were measured and the periodontal status was classified from grade 0 (physiological periodont) to 3 (severe periodontitis). The periodontal status correlated significantly with an increasing concentration of volatile sulfur compounds (VSC, r=0.854) determined with a Halimeter, indicating a positive correlation between the presence of VSC-producing bacteria and periodontitis. In this study Treponema spp. of phylogenetic groups III, V-VII were not detected in any sample, whereas T. denticola-like treponemes were found only in 2 of 51 animals. However, treponemes belonging to phylogenetic groups I, II and IV of oral treponemes or T. socranskii were found in up to 64.84% of the dogs. The detection rate of Treponema spp. was significantly associated with an increased periodontal status. Treponemes present in periodontal lesions were also visualized by fluorescence in situ hybridization of gingival biopsies showing Treponema spp. not only in the microbial biofilm but also within the gingival tissue. The data presented here indicate that oral Treponema spp. are associated with canine periodontitis. Similar to human periodontitis, treponemes of groups I, II and IV and T. socranskii were found more frequently the higher the degree of periodontitis was.  相似文献   

Real-time PCR-based prevalence study, infection follow-up and molecular characterization of canine hemotropic mycoplasmas   总被引：1，自引：0，他引：1  

Wengi N  Willi B  Boretti FS  Cattori V  Riond B  Meli ML  Reusch CE  Lutz H  Hofmann-Lehmann R 《Veterinary microbiology》2008,126(1-3):132-141

Hemotropic mycoplasmas (hemoplasmas) have been reported in several mammalian species including dogs. Infections may lead to hemolytic anemia, but investigations in the dog had been hampered by the lack of adequate diagnostic methods. Only recently sensitive PCR-based assays were reported for the two canine hemoplasmas, Mycoplasma haemocanis and Candidatus Mycoplasma haematoparvum. By applying these assays, 15.4% of 460 dogs from the south of France tested hemoplasma positive. It was hypothesized that this high prevalence may be associated with the presence of Rhipicephalus sanguineus, a proposed vector for canine hemoplasmas. To address this hypothesis and expand the PCR-based knowledge on canine hemoplasmosis, we investigated dogs in a climatic zone that does not allow for the permanent establishment of R. sanguineus. Blood samples were collected throughout a year from 889 dogs in Switzerland: 1.2% of the dogs tested real-time PCR positive. The infection status was not significantly associated with anemia, age or gender. Phylogenetic analyses of Candidatus M. haematoparvum and M. haemocanis isolates revealed > or =99.8% identity to published sequences. All samples collected from three infected dogs throughout a follow-up period of < or =13 months tested PCR positive. Interestingly, the majority of the infected dogs either had been imported from or had visited regions where R. sanguineus is indigenous. Thus, canine hemoplasma prevalence was found to be low in a country with a climate incompatible with frequent occurrence of R. sanguineus. Nonetheless, veterinarians may expect hemoplasma infections in dogs with a travel history and/or after potential tick vector exposure.  相似文献   

IGF-I- and EGF-dependent DNA synthesis of porcine myoblasts is influenced by the dietary isoflavones genistein and daidzein     

Mau M  Kalbe C  Wollenhaupt K  Nürnberg G  Rehfeldt C 《Domestic animal endocrinology》2008,35(3):281-289

Soy-derived isoflavones have been reported to be specific inhibitors of protein tyrosine kinases like the type 1 insulin-like growth factor receptor (IGF-1R) and the epidermal growth factor receptor (EGFR). This study was conducted to investigate, whether IGF-I and EGF stimulate porcine myoblast growth and whether the responses are influenced by isoflavones. Satellite cell-born myoblasts derived from the semimembranosus muscle of newborn piglets were treated for 26h with IGF-I or EGF alone and in combination with genistein or daidzein. The DNA amount was measured and DNA synthesis was recorded as 6 h-[(3)H]thymidine incorporation during exponential growth in serum-free basal medium. IGF-I and EGF synergistically stimulated DNA synthesis of porcine myoblast with EGF causing a greater response. Genistein (100mumol/l) effectively reduced the growth factor-mediated DNA synthesis, which was associated with an inhibition of growth factor receptor protein expression. In response to daidzein no reduction in growth factor-mediated DNA synthesis was found. Daidzein (1; 10mumol/l) combined with IGF-I caused even a slight increase in DNA amount compared with the untreated control. The expression of the IGF-1R precursor protein was reduced with 10 and 100mumol/l daidzein, whereas the EGFR expression remained unchanged with daidzein. The results suggest that dietary isoflavones may interact with growth factor-induced stimulation of pig skeletal muscle growth.  相似文献