Recovery of brodifacoum in vomitus following induction of emesis in dogs that had ingested rodenticide bait     

KH Parton  EK Willson  MG Collett  LH Booth 《New Zealand veterinary journal》2018,66(1):41-43

AIM: To assess the benefit of inducing emesis in dogs that have ingested rodenticide bait containing brodifacoum (BDF), by determining the amount of BDF in bait recovered from the vomitus relative to the estimated amount consumed.

METHODS: Between 2014 and 2015 samples of vomitus from seven dogs that ingested rodenticide baits containing BDF were submitted by veterinarians in New Zealand. All seven dogs had been given apomorphine by the veterinarian and vomited within 1 hour of ingesting the bait. Some or all of the bait particles were retrieved from each sample and were analysed for concentrations of BDF using HPLC. Based on estimations of the mass of bait consumed, the concentration of BDF stated on the product label, and the estimated mass of bait in the vomitus of each dog, the amount of BDF in the vomited bait was calculated as a percentage of the amount ingested.

RESULTS: For five dogs an estimation of the mass of bait ingested was provided by the submitting veterinarian. For these dogs the estimated percentage of BDF in the bait retrieved from the vomitus was between 10–77%. All dogs were well after discharge but only one dog returned for further testing. This dog had a normal prothrombin time 3 days after ingestion.

CONCLUSIONS AND CLINICAL RELEVANCE: The induction of emesis within 1 hour of ingestion can be a useful tool in reducing the exposure of dogs to a toxic dose of BDF. The BDF was not fully absorbed within 1 hour of ingestion suggesting that the early induction of emesis can remove bait containing BDF before it can be fully absorbed.  相似文献   

Housing- and management-specific effects on the health of swine     

Waldmann KH 《DTW. Deutsche tier?rztliche Wochenschrift》2003,110(8):328-330

Important diseases with regard to inadequate housing and management conditions in pig production are given. Typical examples like claw lesions, cannibalism and infectious factorial diseases are described. Beside negative factors of pig housing and management which are of particular pathogenic importance some aspects of disease control and herd health are listed finally.  相似文献   

CO2-stunning of slaughter pigs: effects on EEG, catecholamines and clinical reflexes     

Hartung J  Nowak B  Waldmann KH  Ellerbrock S 《DTW. Deutsche tier?rztliche Wochenschrift》2002,109(3):135-139

Investigations were carried out on the response of slaughter pigs to CO2 stunning with two different gas concentrations (80 vol%, 90 vol%, 73 s) under practical conditions in a one gondola-dip-lift system. EEG measurements were performed and blood constituents such as catecholamines (adrenaline, nor-adrenaline) and lactate as well as clinical reactions (nasal septum and corneal reflex, heart beats) investigated. Special EEG-electrodes were adapted for the measurement on pigs and a mobile data logger was prepared for the use in the lairage of the slaughter house and in the stunning unit. The CO2 concentrations were measured continuously close to the head of the pigs when transported up and down in the stunning gondola. The results show that the technique is suited to monitor the effects of different CO2 gas concentrations on the EEG of the pigs under practical conditions. There is strong evidence that CO2 concentrations of 80 vol% applied over 70 s as required by law are not sufficient to stun pigs properly. A large part of the animals still showed typical reflexes when leaving the stunning pit. When an atmosphere of 90 vol% CO2 is applied, most animals are already dead before bleeding commences. This may create problems in respect to meat hygiene. The blood analysis revealed very high concentrations of catecholamines after stunning. The values for adrenaline and nor-adrenaline in the sticking blood rose by a factor of about 1000 as compared to the concentrations in blood samples taken in the lairage before stunning. It seems necessary to revise the current legislation on gas stunning and to look in greater detail in the effects of CO2 stunning on the welfare of slaughter pigs.  相似文献   

Immunization of Sows in an Integrated Pig‐breeding Herd using a Homologous Inactivated Salmonella Vaccine Decreases the Prevalence of Salmonella typhimurium Infection in the Offspring     

U. Roesler  P. Heller  K.‐H. Waldmann  U. Truyen  A. Hensel 《Zoonoses and public health》2006,53(5):224-228

The efficacy of a homologous vaccination in preventing infection of suckling piglets with Salmonella (S.) Typhimurium was evaluated after an immunization of pregnant sows using an inactivated herd‐specific S. Typhimurium vaccine. Twenty‐five pregnant sows were vaccinated three times antepartum. The efficiency of this vaccine regime was assessed by comparison with a control group of 37 sows and their suckling piglets, which were daily treated with enrofloxacin from day 14 antepartum until the day of weaning. From the first day of life until day 142 post‐partum, faecal samples of the piglets were collected and analysed for Salmonella shedding. In parallel, systemic antibody responses were monitored using a whole cell‐based isotype‐specific enzyme‐linked immunosorbent assay (ELISA). The bacteriological investigation showed marked effects of vaccination. Salmonella Typhimurium could not be detected in any of the faecal samples of the piglets from the vaccinated sows. In contrast, the piglets of the group with long‐time antibiotic treatment shed salmonellae rating to 47.4% of the animals. Furthermore, the offspring from vaccinated sows showed significantly decreased antibody activities of immunoglobulin (Ig)A and IgG. These bacteriological and serological results indicate a significantly lower Salmonella prevalence in piglets of the vaccinated group. As this study shows, the presented strategy of vaccination of pregnant sows with an inactivated Salmonella vaccine seems to be a suitable measure in decreasing Salmonella prevalence in offspring of infected sows.  相似文献   

Maldftreu     

v. Waldmann 《European Journal of Forest Research》1857,1(2):73-79

Ohne Zusammenfassung  相似文献   

The structure, function, and expression of interleukin-2 receptors on normal and malignant lymphocytes   总被引：56，自引：0，他引：56  

T A Waldmann 《Science (New York, N.Y.)》1986,232(4751):727-732

Antigen or mitogen-induced activation of resting T cells induces the synthesis of interleukin-2 (IL-2) as well as the expression of specific cell surface receptors for this lymphokine. Failure of the production of either IL-2 or its receptor results in a failure of the T-cell immune response. The receptor is composed of a 33,000-dalton (251-amino acid) peptide precursor that is post-translationally glycosylated into the mature 55,000-dalton form. In contrast to resting T cells, human T-cell lymphotrophic virus I (HTLV-I)-associated adult T-cell leukemia cells constitutively express large numbers of IL-2 receptors. Because IL-2 receptors are present on the malignant T cells but not on normal resting cells, clinical trials have been initiated in which patients with adult T-cell leukemia are treated with a monoclonal antibody that binds to the IL-2 receptor.  相似文献   

Monoclonal antibodies in diagnosis and therapy   总被引：20，自引：0，他引：20  

T A Waldmann 《Science (New York, N.Y.)》1991,252(5013):1657-1662

Monoclonal antibodies have been applied clinically to the diagnosis and therapy of an array of human disorders, including cancer and infectious diseases, and have been used for the modulation of immune responses. Effective therapy using unmodified monoclonal antibodies has, however, been elusive. Recently, monoclonal antibody-mediated therapy has been revolutionized by advances such as the definition of cell-surface structures on abnormal cells as targets for effective monoclonal antibody action, genetic engineering to create less immunogenic and more effective monoclonal antibodies, and the arming of such antibodies with toxins or radionuclides to enhance their effector function.  相似文献   

A proposal of clinical breakpoints for amoxicillin applicable to porcine respiratory tract pathogens     

Schwarz S  Böttner A  Goossens L  Goosens L  Hafez HM  Hartmann K  Kaske M  Kehrenberg C  Kietzmann M  Klarmann D  Klein G  Krabisch P  Luhofer G  Richter A  Schulz B  Sigge C  Waldmann KH  Wallmann J  Werckenthin C 《Veterinary microbiology》2008,126(1-3):178-188

In the present position paper, an attempt was made to establish clinical breakpoints of amoxicillin to classify porcine respiratory tract pathogens as susceptible, intermediate or resistant based on their minimum inhibitory concentrations of amoxicillin. For this, a thorough review of the published literature with regard to swine-specific pharmacological data (including dosages of amoxicillin applied and routes of administration used), clinical efficacy, and in vitro susceptibility of the target pathogens was performed. Based on the comparative analysis of the results, the working group "Antibiotic Resistance" of the German Veterinary Medical Society (DVG) proposed to classify porcine respiratory tract pathogens that show MIC values of amoxicillin of < or =0.5microg/ml as "susceptible", those with MICs of 1microg/ml as "intermediate", and those with MICs of > or =2microg/ml as "resistant".  相似文献   

Equine amnionitis and fetal loss: The case definition for an unrecognised cause of abortion in mares     

KH Todhunter  NR Perkins  RM Wylie  C Chicken  AJ Blishen  DJ Racklyeft  G Muscatello  MC Wilson  PL Adams  JR Gilkerson  WL Bryden  AP Begg 《Australian veterinary journal》2009,87(1-2):35-38

A series of abortions occurred in mares in New South Wales during 2004 that involved similar and unusual findings on post mortem examination of aborted fetuses and fetal membranes. The term Equine Amnionitis and Fetal Loss (EAFL) was developed to describe the condition. This form of abortion had not been previously recognised in Australia. The pathology alone is not specific for EAFL and diagnosis requires demonstration of a combination of certain pathological and bacteriological features. The purpose of this paper is to describe patterns considered consistent with EAFL cases as a working case definition for use by veterinarians and veterinary pathologists in identifying future cases of EAFL. More detailed papers are in preparation to fully describe the epidemiological, histopathological, and microbiological aspects of EAFL.  相似文献   

Evaluation of histamine-provoked changes in airflow using electrical impedance tomography in horses     

Cristy Secombe  Andreas D. Waldmann  Giselle Hosgood  Martina Mosing 《Equine veterinary journal》2020,52(4):556-563

  相似文献