Tuberculosis in cattle: the results of the four-area project     

Griffin JM  More SJ  Clegg TA  Collins JD  O'Boyle I  Williams DH  Kelly GE  Costello E  Sleeman DP  O'Shea F  Duggan M  Murphy J  Lavin DP 《Irish veterinary journal》2005,58(11):629-636

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Iridium-192 interstitial brachytherapy as adjunctive treatment for canine cutaneous mast cell tumors     

Northrup NC  Roberts RE  Harrell TW  Allen KL  Howerth EW  Gieger TL 《Journal of the American Animal Hospital Association》2004,40(4):309-315

Eleven dogs with cutaneous mast cell tumors (MCTs) were treated with surgery and iridium-192 ((192)Ir) interstitial brachytherapy. Minimum tumor doses ranged from 47.2 to 63.3 Gy. Treated tumors were classified as grade II (n=7) or III (n=4). Five dogs had recurrences with a median progression-free interval of 1391 days, and six dogs had no recurrence at a median follow-up time of 942 days. Acute adverse effects were well tolerated, and late effects were mild. One dog developed a second tumor of a different cell type in the radiation treatment field.  相似文献   

Intracerebral plasma cell tumor in a cat: a case report and literature review     

Greenberg MJ  Schatzberg SJ  deLahunta A  Stokol T  Summers BA 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2004,18(4):581-585

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Immune responses to a Staphylococcus aureus GapC/B chimera and its potential use as a component of a vaccine for S. aureus mastitis     

Perez-Casal J  Prysliak T  Kerro-Dego O  Potter AA 《Veterinary immunology and immunopathology》2006,109(1-2):85-97

Bovine mastitis caused by strains of S. aureus is the most economically important disease affecting the dairy industry worldwide. Commercially available vaccines show various degrees of success and work in research laboratories with experimental vaccines suggests that in part, the failure of these vaccines lies in the limited antigenic repertoire contained in the vaccine formulations. Since it seems impractical to produce a vaccine containing antigens from all major S. aureus mastitis isolates, we took the approach of using two surface antigens GapB and GapC that appear to be conserved and constructed a GapC/B chimera as the basis for a vaccine. The humoral and cellular immune responses to GapC/B were compared to the responses to the individual proteins, alone or in combination. The GapC/B protein elicited strong humoral and cellular responses in mice as judged by the levels of total IgG, IgG1, IgG2a, and number of IL-4- and IFN-gamma-secreting cells. These results suggest that this chimeric protein could be an attractive target for further vaccine efficacy studies.  相似文献   

Fell Pony syndrome in a pony in North America     

Gardner RB  Hart KA  Stokol T  Divers TJ  Flaminio MJ 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2006,20(1):198-203

A 5-week-old Fell Pony colt was examined for fever, lethargy, and anemia. The colt had been lethargic for 1 week before examination, had continued to nurse, had a temperature of 104°F (40°C), and was treated with ceftiofur (5 mg/kg IM q12h). Approximately 36 hours before examination, the colt developed watery diarrhea. Blood work performed by the referring veterinarian on the day of admission revealed a PCV of 10%.  相似文献   

Aspects of future animal health: the Animal Health Foresight Project     

Willis NG 《Journal of veterinary medical education》2006,33(4):567-570

Against a background of social, political, and environmental change, the challenge to provide the most appropriate education for future veterinarians is daunting. A consideration of the multiple roles of veterinarians in our future society indicates that a different perspective is essential for progress to be made. One example of an approach to reach such a perspective is the Animal Health Foresight Project, which was jointly sponsored in 2005 by the Canadian Food Inspection Agency and the US Department of Agriculture. A new paradigm emerged from this study. This article explores the conclusions of this project and their potential implications for the future of animal health and for veterinary medical education. Outcomes of the Foresight Project led to the development of a new paradigm. The implications for and the possible influence on future animal health and on veterinary medical education are contemplated.  相似文献   

What is natural? The need for a long-term perspective in biodiversity conservation   总被引：1，自引：0，他引：1  

Willis KJ  Birks HJ 《Science (New York, N.Y.)》2006,314(5803):1261-1265

Ecosystems change in response to factors such as climate variability, invasions, and wildfires. Most records used to assess such change are based on short-term ecological data or satellite imagery spanning only a few decades. In many instances it is impossible to disentangle natural variability from other, potentially significant trends in these records, partly because of their short time scale. We summarize recent studies that show how paleoecological records can be used to provide a longer temporal perspective to address specific conservation issues relating to biological invasions, wildfires, climate change, and determination of natural variability. The use of such records can reduce much of the uncertainty surrounding the question of what is "natural" and thereby start to provide important guidance for long-term management and conservation.  相似文献   

The consensus coding sequences of human breast and colorectal cancers     

Sjöblom T  Jones S  Wood LD  Parsons DW  Lin J  Barber TD  Mandelker D  Leary RJ  Ptak J  Silliman N  Szabo S  Buckhaults P  Farrell C  Meeh P  Markowitz SD  Willis J  Dawson D  Willson JK  Gazdar AF  Hartigan J  Wu L  Liu C  Parmigiani G  Park BH  Bachman KE  Papadopoulos N  Vogelstein B  Kinzler KW  Velculescu VE 《Science (New York, N.Y.)》2006,314(5797):268-274

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Resection and use of a cyclooxygenase-2 inhibitor for treatment of pancreatic adenocarcinoma in a cockatiel     

Chen S  Bartick T 《Journal of the American Veterinary Medical Association》2006,228(1):69-73

CASE DESCRIPTION: A 5-year-old sexually intact male cockatiel was examined because of progressive dyspnea of 1 week's duration. CLINICAL FINDINGS: On auscultation of the lungs and air sacs, crackles were detected; the abdomen was distended and fluctuant on palpation. Eleven milliliters of clear yellow fluid was collected via abdominocentesis. Radiography (with and without contrast medium) and ultrasonography revealed a soft tissue mass in the caudoventral portion of the coelom. TREATMENT AND OUTCOME: Exploratory surgery of the coelomic cavity was performed and the neoplasm was excised. Histologic examination of the neoplasm was consistent with a high-grade pancreatic exocrine adenocarcinoma. Celecoxib, a cyclooxygenase (COX)-2 inhibitor, was administered for pain management and for potential antineoplastic activity. For 4.5 months after surgery, the bird had no recurrence of clinical signs; however, dyspnea recurred and during evaluation, the bird died. Necropsy findings indicated that the pancreatic adenocarcinoma had metastasized to surrounding tissues and vessels, which was not unexpected given the high grade assigned to the neoplasm during histologic analysis. CLINICAL RELEVANCE: Pancreatic neoplasms are associated with a poor prognosis, regardless of treatment modality. Celecoxib can be administered as palliative treatment to affected birds, but as with any nonsteroidal anti-inflammatory drug, COX-2 inhibitors should be used cautiously because they can adversely affect renal function by decreasing renal prostaglandin synthesis.  相似文献   

Climate change. Regional sea-level projection     

Willis JK  Church JA 《Science (New York, N.Y.)》2012,336(6081):550-551

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