IBD组织灭活油乳苗的研制和应用     

方光远  陈玉林  李晓东 《金陵科技学院学报》1997,(3)

采用1BD发病鸡法氏囊、脾脏研制成组织灭活油乳苗，经田间试验表明，免疫保护率达100％。  相似文献   

实验性鸡法氏囊病的病毒在体内分布及其消长规律研究     

陈创夫  马正海 《塔里木大学学报》1997,9(2):5-10

本实验用免疫酶组化法分析雏鸡接种ＩＢＤＶ后，病毒在体内分布和病理变化，接种后６，１２，２４，４８，７２，９６，１２０，１４４，１６８，１９２，２１６，２４０小时扑杀，每次扑杀５只。对照组雏鸡与实验组同步扑杀，每次扑杀３只。结果表明：雏鸡感染ＩＢＤＶ后，要从其法氏囊，胸腺，脾脏，盲肠扁桃体，哈德氏腺，肝脏，肾脏，腺胃，小肠，盲肠和肺脏等器官检出ＩＢＤＶ。  相似文献   

鸡传染性法氏囊病红细胞上C_(3b)受体的变化     

张德成  林明奕  陈思义  关润培  李进昌 《浙江大学学报(农业与生命科学版)》1991,(1)

对自然发病的7例传染性法氏囊病鸡红细胞上C_(3b)受体的变化进行了检测,,并与10例健康鸡进行比较,发现患病鸡红纲胞上C_(3b)受体明显低于健康鸡,而红细胞上免疫复合物,两者相比变化甚微,这一结果进一步说明传染性法氏囊病毒主要侵害鸡的免疫系统,检测红细胞上C_(3b)受体的变化,亦可作为诊断该病的手段之一。  相似文献   

抗IBD和ND双价高免卵黄抗体的研制与应用   总被引：1，自引：0，他引：1  

郑厚旌  周大生 《河南农业大学学报》1992,26(2):144-148

  相似文献   

鸡传染性法氏囊病的诊疗报告     

张绮琼 《畜禽业》2001,(6):48-49

鸡传染性法氏囊病是一种传播迅速、危害极大的急性、高度接触性传染病。在受IBDV污染严重的环境下，若消毒不严格，免疫预防不当，易造成鸡群发病。2000年秋季白云区某鸡场发生IBD，经实验室诊断后及时采取措施进行防制，取得了良好的效果。本文对本次发病的诊断与防制情况进行简要介绍。  相似文献   

Emerging Involvement of long non-coding RNAs in gastrointestinal associated inflammatory disorders     

《Comparative immunology, microbiology and infectious diseases》2020

Gastrointestinal (GI) disorders including a wide range of infectious, inflammatory, autoimmune, etc. disorders. Inflammatory bowel and celiac disease are non-fatal but overwhelming GI associated disorders. IBD and celiac’s complications, besides the great suffering, disturb the normal life of the patients and make them involved in mental and physical problems. The emerging role of genetic content is deniable for GI inflammatory disorders incidence, and long non-coding RNAs (lncRNAs) function is the recent topic for its association. Analyzing of absolute lncRNAs interference in GI inflammatory appearance remains in infancy, and more studies are requested. Here, we concisely performed a systematic review in the last knowledge up to 2020 to identify all of the significant lncRNAs associated with the initiation and progression of GI inflammatory diseases. Accordingly, this assay attempted to refer to the expression of lncRNAs changing from the normal state, discovery of genetic mechanisms, and main effectors that would trigger associated IBD and celiac expression and immune responses would be effective for therapeutic approaches. It could be useful for prognostic and diagnostic purposes of GI associated inflammatory disorders.  相似文献   

Dissection of identical-by-descent segments during the formation of foundation parents derived from Suwan germplasm of maize     

Xiangyang Guo  Xun Wu  Wenqiang Wu  Angui Wang  Pengfei Liu  Yunfang Zhu  Hong Ren  Zehui Chen  Hongbing Luo 《Plant Breeding》2020,139(5):862-869

Suwan germplasm plays important roles in maize breeding in tropical/subtropical regions, especially in southern China. To analyze the genetic characteristics of Suwan maize germplasm, one panel of 73 lines derived from the Suwan population and temperate resources were collected and genotyped using 56,110 single-nucleotide polymorphism (SNP) markers. The results revealed four subgroups, namely, QR273, Ki32, HCL645, and PH4CV, with an average genetic distance of 0.304, varying from 0.001 to 0.370. In addition, many identical-by-descent (IBD) segments were found among Suwan germplasms and their descendants, of which 78 segments were detected only in the QR273 subgroup, 18 segments were detected only in the Ki32 subgroup, 53 and 11 segments were detected only in the PH4CV and the HCL645 subgroup, respectively. Pairwise comparisons showed that 13 segments were common between the QR273 and Ki32 subgroups, 5 segments were common between the QR273 and HCL645 subgroups, 26 segments were common between the QR273 and PH4CV subgroups. Five and 14 segments were common between the Ki32 versus HCL645 subgroups and Ki32 versus PH4CV subgroups. Three segments were commonly detected in the Ki32, QR273, and HCL645 subgroups. Candidate gene analysis showed that 132 genes were located in these segments, wherein seven new candidate genes were associated with flower time (FT)-related traits, which were located in the IBD segments of QR273 or HCL645. Zm00001d033130_T005 and Zm00001d013768_T001 were located in the IBD segments specific to the QR273 subgroup. These two genes function in cell differentiation and flower development and would be very important for the phenotypic variations of the given FP subgroups. These results provide new insights and scientific proof for dissecting the genetic basis of complex traits and the utilization of Suwan germplasm in future maize breeding.  相似文献   

Comparison of Oral Prednisone and Prednisone Combined with Metronidazole for Induction Therapy of Canine Inflammatory Bowel Disease: A Randomized‐Controlled Trial     

A.E. Jergens  J. Crandell  J.A. Morrison  K. Deitz  M. Pressel  M. Ackermann  J.S. Suchodolski  J.M. Steiner  R. Evans 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2010,24(2):269-277

Background: Although prednisone and metronidazole are commonly used to treat canine inflammatory bowel disease (IBD), no randomized‐controlled trials have been performed. Hypothesis: Combination drug therapy with prednisone and metronidazole will be more effective than prednisone alone for treatment of canine IBD. Reduction in disease severity will be accompanied by decreased canine IBD activity index (CIBDAI) scores and serum C‐reactive protein (CRP) concentrations. Animals: Fifty‐four pet dogs diagnosed with IBD of varying severity. Methods: Dogs were randomized to receive oral prednisone (1 mg/kg; n = 25) or prednisone and metronidazole (10 mg/kg; n = 29) twice daily for 21 days. Clinical (CIBDAI) scores and serum CRP were determined at diagnosis and after 21 days of drug therapy. The primary efficacy measure was remission at 21 days, defined as a 75% or greater reduction in baseline CIBDAI score. Results: Differences between treatments in the rate of remission (both exceeding 80%) or the magnitude of its change over time were not observed. CRP concentrations in prednisone‐treated dogs were increased because of many dogs having active disease. Both treatments reduced CRP in comparison with pretreatment concentrations. An interaction between CIBDAI and CRP was identified in 42 of 54 dogs (78%), whereas 8 of 54 dogs (15%) showed disagreement between these indices. Conclusions and Clinical Importance: Prednisone is as effective as combined treatment with prednisone and metronidazole for induction therapy of canine IBD. CRP may be normal or increased in dogs with IBD and may be useful in assessing the response of individual dogs to treatment along with changes in the CIBDAI.  相似文献   

茶叶对IBD肠道微生物菌群影响研究进展     

谭婷  刘武嫦  仇云龙  周颖  杨哲  周琳  禹利君 《茶叶通讯》2016,(3):37-40

茶叶具备独特的品质特征和保健功效,丰富的内含成分使其具有多种生物活性。近年来,各研究已清楚地表明茶叶具有调节IBD肠道微生物失调,增强机体免疫,调节消化道代谢,显著改善腹泻和结肠损伤等功效。本文就国内外关于茶叶中茶多酚、茶色素、茶多糖、茶皂素等有效成分对IBD肠道微生物菌群多样性影响的实验研究进行综述。  相似文献   

传染性法氏囊病沉淀抗体水平与免疫保护关系的研究     

程太平  谢耀庭  杨晓林  荣俊  张地  张磊  邹浩勇  王怀林  佘全初  王成举 《动物医学进展》2005,26(11):90-93

以传染性法氏囊病(IBD)基因工程重组亚单位油乳剂疫苗及其重组活载体疫苗实验室试制品免疫SPF鸡,以法氏囊眼观病变及法氏囊中IBDV抗原检测结果来评定免疫保护效力。结果血清IBDV沉淀抗体水平达到1/8的鸡能抵抗IBDV强毒的攻击,低于1/4的部分鸡不能抵抗IBDV强毒的攻击。经t检验,在以血清IBDV沉淀抗体水平≥1/8所得百分率、血清IBDV沉淀抗体水平≥1/4所得百分率、法氏囊眼观变化正常鸡只百分率及法氏囊中IBDV抗原检测的阴性率之间差异都不显著。表明以血清IBDV沉淀抗体水平≥1/4所得百分率与法氏囊中IBDV抗原检测的阴性率和法氏囊眼观变化正常鸡只百分率一样,适用于评定攻毒免疫保护效力。  相似文献