Effects of propofol administration rates on cardiopulmonary function and anaesthetic depth during anaesthetic induction in rats     

Hwan S Jang DVM  PhD    Hyo S Choi MS  & Maan-Gee Lee MD  PhD 《Veterinary anaesthesia and analgesia》2009,36(3):239-245

Objective  To compare the effect of three different administration rates of one dose of propofol on the depth and duration of anaesthesia and cardiopulmonary function during induction of anaesthesia in rats using electroencephalogram (EEG) and clinical signs.
Study design  Prospective, randomized experimental trial.
Animals  Twenty-one, adult, male Sprague-Dawley rats weighing 341 ± 26 g (mean ± SD) (325 to 480 g).
Methods  Animals were randomly divided into three groups to receive 20 mg kg⁻¹ propofol as a bolus injection over 1, 2 or 3 minutes (groups P1, P2 and P3 respectively) intravenously (IV). The total duration and number of burst suppression (BS) episodes in the EEG, the time to loss of righting reflex, reflex score from electrical stimulation, respiratory rate, mean arterial pressure and pulse rate were measured from the beginning of propofol injection.
Results  While loss of reflex to electrical stimulus and time to loss of righting reflex in group P3 were slower than in other groups, the total duration and number of BS episodes in group P3 were significantly higher than in groups P1 and P2 and cardiopulmonary depression was less prominent in group P3 than in groups P1 and P2 up to 2 minutes after the start of administration.
Conclusions  Twenty milligram per kg propofol administration IV for 3 minutes increased the duration of anaesthesia and decreased cardiopulmonary depression in rats.
Clinical relevance  Slower infusion of propofol produced surgical anaesthesia with less cardiopulmonary depression in rats.  相似文献   

The effect of the novel alpha‐2‐adrenoceptor agonist naphthylmedetomidine on pulse rate,arterial blood pressure and sedation in rabbits     

Ladislav Hess MD  PhD  Martin Votava MD  PhD  Jitka Schreiberová MD  Jiří Málek MD  PhD 《Veterinary anaesthesia and analgesia》2009,36(2):144-150

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疏血通对慢性肺心病急性加重期患者的疗效观察   总被引：2，自引：0，他引：2  

陈华新  许志明  苏小妹 《湛江医学院学报》2008,26(2):143-145

目的观察疏血通注射液对慢性肺心病急性加重期患者的疗效。方法将慢性肺心病急性加重期患者50例随机分为常规治疗组(25例)和疏血通治疗组(25例)。常规治疗组利用常规的综合治疗,疏血通治疗组在综合治疗的基础上加用疏血通治疗。入院时、治疗后第8天停止吸氧30min后均分别测动脉血气分析及血液流变学指标。结果常规治疗组疗效劣于疏血通治疗组(Hc=3.9100,P<0.05)。疏血通治疗组动脉血二氧化碳分压(PaCO2)、血液流变学指标和肺动脉平均压显著低于常规治疗组,动脉血氧分压(PaO2)高于常规治疗组,差异均有统计学意义(P<0.01)。结论疏血通可降低慢性肺心病急性加重期患者血流粘滞度及肺动脉高压,升高PaO2水平,降低PaCO2水平,提高治疗效果。  相似文献   

Successful Nonextracorporeal Life Support Resuscitation and Rewarming of a Patient with Hypothermia in Cardiac Arrest     

《The Forestry Chronicle》2022,33(4):476-478

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Effects of intramuscular vatinoxan (MK-467), co-administered with medetomidine and butorphanol,on cardiopulmonary and anaesthetic effects of intravenous ketamine in dogs     

《Veterinary anaesthesia and analgesia》2020,47(5):604-613

ObjectiveTo investigate the impact of intramuscular (IM) co-administration of the peripheral α₂-adrenoceptor agonist vatinoxan (MK-467) with medetomidine and butorphanol prior to intravenous (IV) ketamine on the cardiopulmonary and anaesthetic effects in dogs, followed by atipamezole reversal.Study designRandomized, masked crossover study.AnimalsA total of eight purpose-bred Beagle dogs aged 3 years.MethodsEach dog was instrumented and administered two treatments 2 weeks apart: medetomidine (20 μg kg^–1) and butorphanol (100 μg kg^–1) premedication with vatinoxan (500 μg kg^–1; treatment MVB) or without vatinoxan (treatment MB) IM 20 minutes before IV ketamine (4 mg kg^–1). Atipamezole (100 μg kg^–1) was administered IM 60 minutes after ketamine. Heart rate (HR), mean arterial (MAP) and central venous (CVP) pressures and cardiac output (CO) were measured; cardiac (CI) and systemic vascular resistance (SVRI) indices were calculated before and 10 minutes after MVB or MB, and 10, 25, 40, 55, 70 and 100 minutes after ketamine. Data were analysed with repeated measures analysis of covariance models. A p-value <0.05 was considered statistically significant. Sedation, induction, intubation and recovery scores were assessed.ResultsAt most time points, HR and CI were significantly higher, and SVRI and CVP significantly lower with MVB than with MB. With both treatments, SVRI and MAP decreased after ketamine, whereas HR and CI increased. MAP was significantly lower with MVB than with MB; mild hypotension (57–59 mmHg) was recorded in two dogs with MVB prior to atipamezole administration. Sedation, induction, intubation and recovery scores were not different between treatments, but intolerance to the endotracheal tube was observed earlier with MVB.Conclusions and clinical relevanceHaemodynamic performance was improved by vatinoxan co-administration with medetomidine–butorphanol, before and after ketamine administration. However, vatinoxan was associated with mild hypotension after ketamine with the dose used in this study. Vatinoxan shortened the duration of anaesthesia.  相似文献   

Resuscitation of an anaesthetised foal with uroperitoneum and ventricular asystole     

H. A. Haga  Å. Risberg  E. Strand 《Equine Veterinary Education》2011,23(10):502-507

A 2‐day‐old male Quarter Horse foal was diagnosed with uroperitoneum and ruptured bladder. Intravenous fluid therapy was initiated prior to anaesthesia and repeated unsuccessful attempts were made to drain the abdomen of accumulated urine. Prior to anaesthesia the foal exhibited clinical signs of abdominal compartment syndrome. When anaesthetised the accumulated urine was drained by free flow through a small abdominal stab incision after aseptic site preparation. A few minutes later electrocardiography indicated second degree atrioventricular block which progressed into third degree atrioventricular block and ventricular asystole. The foal was resuscitated by closed chest compressions, mechanical ventilation, sympathomimetic and antimuscarinergic drugs. When anaesthetising these neonatal patients one must be prepared to handle potentially fatal cardiac arrhythmias and, prior to surgery, the danger posed by increased intra‐abdominal pressure should be weighed against the need for diluting plasma potassium.  相似文献   

Repeatability, reproducibility, and effect of head position on central venous pressure measurement in standing adult horses     

Norton JL  Nolen-Walston RD  Underwood C  Boston R  Slack J  Dallap BL 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2011,25(3):575-578

Background: Central venous pressure (CVP) is a used as an estimation of intravascular volume status in various species. Techniques for measuring CVP in horses have been described, but the repeatability of these readings at a single time point or over time has not been established. Hypothesis: That CVP measurements in healthy adult horses would be repeatable at each time point, that these readings would be reproducible over time, and that alteration in head position relative to the heart would alter CVP. Animals: Ten healthy adult research horses. Methods: In an experimental study, horses were instrumented with a central venous catheter. Readings were taken in triplicate q6h for 2 days by water manometry, and twice daily with the head in neutral, elevated, and lowered positions by electronic manometry. Results: Variation in the “neutral” measurements obtained at each time point was <0.1 ± 1.0 cmH₂O (P= .718). There was a significant decrease in CVP over time (P= .015), which was eliminated when results were controlled for acute decrease in body weight of ?1.35% (presumed hypohydration because of lack of acclimatization and decreased water intake). Head height had a significant and directional effect on CVP in that the elevated head position decreased CVP ?2.0 ± 6.5 cmH₂O (P < .001) while the lowered head position increased CVP by 3.7 ± 5.5 cmH₂O (P < .001). Conclusions and Clinical Importance: CVP values obtained by water manometry were repeatable in adult horses, but were reproducible only when controlled for changes in hydration. Care should be taken to maintain consistency in head position to prevent erroneous readings.  相似文献   

The use of intravenous lipid emulsion as an antidote in veterinary toxicology     

Alberto L. Fernandez DVM  Justine A. Lee DVM  DACVECC  Louisa Rahilly DVM  DACVECC  Lynn Hovda DVM  RPH  MS  DACVIM  Ahna G. Brutlag DVM  MS  Kristin Engebretsen PharmD  DABAT 《Journal of Veterinary Emergency and Critical Care》2011,21(4):309-320

Objective – To review the use of IV lipid emulsion (ILE) for the treatment of toxicities related to fat‐soluble agents; evaluate current human and veterinary literature; and to provide proposed guidelines for the use of this emerging therapy in veterinary medicine and toxicology. Data Sources – Human and veterinary medical literature. Human Data Synthesis – Human data are composed mostly of case reports describing the response to treatment with ILE as variant from mild improvement to complete resolution of clinical signs, which is suspected to be due to the variability of lipid solubility of the drugs. The use of ILE therapy has been advocated as an antidote in cases of local anesthetic and other lipophilic drug toxicoses, particularly in the face of cardiopulmonary arrest and unsuccessful cardiopulmonary cerebral resuscitation. Veterinary Data Synthesis – The use of ILE therapy in veterinary medicine has recently been advocated by animal poison control centers for toxicoses associated with fat‐soluble agents, but there are only few clinical reports documenting successful use of this therapy. Evidence for the use of ILE in both human and veterinary medicine is composed primarily from experimental animal data. Conclusions – The use of ILE appears to be a safe therapy for the poisoned animal patient, but is warranted only with certain toxicoses. Adverse events associated with ILE in veterinary medicine are rare and anecdotal. Standard resuscitation protocols should be exhausted before considering this therapy and the potential side effects should be evaluated before administration of ILE as a potential antidote in cases of lipophilic drug toxicoses. Further research is waranted.  相似文献   

In vitro evaluation of the efficacy of a veterinary dry heat fluid warmer     

Vivian Chiang DVM  Kate Hopper PhD  BVSc  DACVECC  Matthew S. Mellema PhD  DVM  DACVECC 《Journal of Veterinary Emergency and Critical Care》2011,21(6):639-647

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Influence of cross‐match on posttransfusion packed cell volume in feline packed red blood cell transfusion     

Joel G. Weltman DVM  Daniel J. Fletcher PhD  DVM  DACVECC  Catherine Rogers DVM  DACVECC 《Journal of Veterinary Emergency and Critical Care》2014,24(4):429-436

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