Elementary response of olfactory receptor neurons to odorants     

Bhandawat V  Reisert J  Yau KW 《Science (New York, N.Y.)》2005,308(5730):1931-1934

Signaling by heterotrimeric GTP-binding proteins (G proteins) drives numerous cellular processes. The number of G protein molecules activated by a single membrane receptor is a determinant of signal amplification, although in most cases this parameter remains unknown. In retinal rod photoreceptors, a long-lived photoisomerized rhodopsin molecule activates many G protein molecules (transducins), yielding substantial amplification and a large elementary (single-photon) response, before rhodopsin activity is terminated. Here we report that the elementary response in olfactory transduction is extremely small. A ligand-bound odorant receptor has a low probability of activating even one G protein molecule because the odorant dwell-time is very brief. Thus, signal amplification in olfactory transduction appears fundamentally different from that of phototransduction.  相似文献   

Chloroplast derived SSRs reveals genetic relationships in domesticated alliums and wild relatives     

Jayaswall  Kuldip  Sharma  Himanshu  Bhandawat  Abhishek  Sagar  R.  Jayaswal  Deepanshu  Kumar  Akash  Chaturvedi  Pratibha  Mahajan  Vijay  Kumar  Sanjay  Singh  Major 《Genetic Resources and Crop Evolution》2022,69(1):363-372

Genetic Resources and Crop Evolution - Alliums comprise of popular spices and used for various culinary purposes and nutraceuticals. Poor genetic characterization and scarce information regarding...  相似文献