Early eocene vertebrates from baja california: evidence for intracontinental age correlations     

Flynn JJ  Novacek MJ 《Science (New York, N.Y.)》1984,224(4645):151-153

Newly discovered fossils support a Wasatchian (early Eocene) age for the Punta Prieta vertebrate fauna of Baja California and reveal the utility of land mammal ages on a continental scale. Dispersal scenarios for late Paleocene and early Eocene vertebrates usually invoke heterochrony for similar, but geographically separated, faunas or taxa. Such heterochrony is not supported by independent geochronologies or adequate geographic samples.  相似文献   

Production of Lambs After the Transfer of Fresh and Cryopreserved in vitro Produced Embryos from Prepubertal Lamb Oocytes and Unsorted and Sex-sorted Frozen-thawed Spermatozoa     

KM Morton  SL Catt  FK Hollinshead  WMC Maxwell  G Evans 《Reproduction in domestic animals》2004,39(6):454-461

Cumulus-oocyte complexes from hormone-stimulated 3-4-week-old (n=43) and 6-7-week-old (n=12) prepubertal lambs were matured in vitro and incubated with unsorted, or X- or Y-spermatozoa separated with a high-speed cell sorter (SX MoFlo)frozen-thawed. Presumptive zygotes were then cultured to the blastocyst stage, and transferred to recipients fresh or after cryopreservation (frozen). Oocyte cleavage was higher (p <0.05) with unsorted (515/926, 55.6%) than X- or Y-spermatozoa (261/672, 38.8% and 229/651, 35.2%, respectively) and blastocyst formation (% zygotes) by Day 9 of in vitro culture was lower (p <0.05) for X- (102/261, 39.1%) than unsorted spermatozoa (249/515, 48.3%), but did not differ between Y-spermatozoa (103/229, 45.0%) and unsorted spermatozoa, or between X- and Y-spermatozoa (p >0.05). For fresh embryos, survival to term was 50.0% (3/6) for unsorted, 0.0% (0/6) for X- and 16.7% (1/6) for Y-spermatozoa-derived embryos (p >0.05), and for frozen embryos was 4.0% (2/50) for unsorted, 9.1% (2/22) for X- and 2.9% (1/34) Y-spermatozoa-derived embryos (p >0.05). Of the two lambs born from X-spermatozoa-derived embryos, one was female (50%), and from the two Y-spermatozoa-derived lambs, both were male (100%), demonstrating that lambs can be produced after the transfer of fresh and cryopreserved IVP embryos derived from prepubertal lamb oocytes and frozen-thawed sex-sorted sperm.  相似文献   

Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury     

Hellal F  Hurtado A  Ruschel J  Flynn KC  Laskowski CJ  Umlauf M  Kapitein LC  Strikis D  Lemmon V  Bixby J  Hoogenraad CC  Bradke F 《Science (New York, N.Y.)》2011,331(6019):928-931

Hypertrophic scarring and poor intrinsic axon growth capacity constitute major obstacles for spinal cord repair. These processes are tightly regulated by microtubule dynamics. Here, moderate microtubule stabilization decreased scar formation after spinal cord injury in rodents through various cellular mechanisms, including dampening of transforming growth factor-β signaling. It prevented accumulation of chondroitin sulfate proteoglycans and rendered the lesion site permissive for axon regeneration of growth-competent sensory neurons. Microtubule stabilization also promoted growth of central nervous system axons of the Raphe-spinal tract and led to functional improvement. Thus, microtubule stabilization reduces fibrotic scarring and enhances the capacity of axons to grow.  相似文献   

Biting attack elicited by stimulation of the ventral midbrain tegmentum of cats   总被引：1，自引：0，他引：1  

R J Bandler  C C Chi  J P Flynn 《Science (New York, N.Y.)》1972,177(46):364-366

An area in the ventral midbrain tegmentum has been discovered in which electrical stimulation elicits biting attack. The midbrain sites from which attack was elicited correspond well with the zone in the midbrain tegmentum where degeneration was previously observed after lesions were made in lateral hypothalamic attack sites.  相似文献   

Impact of ready-to-eat breakfast cereal (RTEBC) consumption on adequacy of micronutrient intakes and compliance with dietary recommendations in Irish adults     

Galvin MA  Kiely M  Flynn A 《Public health nutrition》2003,6(4):351-363

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Pet travel scheme     

Fee C  Flynn T  Goddard P 《The Veterinary record》2000,147(5):143

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中国赢得美国木制品市场份额     

ByRobertFlynn 《国际木业》2003,33(9):1-2

木材资源国际公司(WRI)是一家位于美国华盛顿州的咨询公司，提供全球木材市场的信息和研究服务。1987年以来，公司已经完成了35个国家的170余个咨询项目。WRI已经同中国木业国际网(China Wood International)共同开展了许多有关木材和木材制品的市场调研项目。我们感到高兴的是中国木业国际网已在从事这个杂志的经营，并且愿意致力于一个定期的栏目，讨论有关中国木材制品的国际贸易方面令人感兴趣的这些问题。这次讨论重点是中国在美国的市场份额持续增长的重要性。  相似文献   

Influence of dietary alpha-tocopherol on tocopherol concentrations in chick tissues     

P J Sheehy  P A Morrissey  A Flynn 《British poultry science》1991,32(2):391-397

1. The effect of feeding alpha-tocopherol (5 to 180 micrograms/g diet) for 24 days on the concentrations of alpha-tocopherol in various chicken tissues was investigated. 2. Tissue alpha-tocopherol concentrations responded to dietary intake in the order: heart congruent to lung greater than liver greater than thigh muscle greater than brain, and in all cases the relationship between the concentrations of dietary and tissue alpha-tocopherol was highly significant (0.997 less than or equal to r less than or equal to 1). 3. Plasma alpha-tocopherol concentration appears to be a good index (r greater than or equal to 0.910, P less than 0.001) of alpha-tocopherol status of lung, liver and heart.  相似文献   

Assessment of obesity and fear of fatness among inner-city Dublin schoolchildren in a one-year follow-up study     

Griffin AC  Younger KM  Flynn MA 《Public health nutrition》2004,7(6):729-735

BACKGROUND: Positive secular trends in adolescent obesity and an increased prevalence of fear of fatness, particularly among girls, have been documented world-wide. There is a lack of consensus about assessment criteria for childhood obesity and no standard exists for assessing Irish children. In 1990, the Irish National Nutrition Survey used body mass index (BMI) > or =26 kg m(-2) to describe the prevalence of overweight among Irish adolescents. OBJECTIVES: (1) To examine the range in classification of Dublin schoolchildren as overweight according to four standard assessment methods; (2) to assess changes in weight status, prevalence of fear of fatness and accompanying slimming practices in a one-year follow-up; and (3) to compare the prevalence of overweight with that documented in 1990 among adolescents of similar age. DESIGN: A one-year follow-up study of 199 healthy schoolchildren (90 boys and 109 girls; mean age of 11 years at baseline) attending seven fee-paying (six single- and one mixed-sex) and eight non-fee-paying (four single- and four mixed-sex) primary schools in Dublin city centre. MEASUREMENTS: Weight, height, waist circumference and triceps skinfold were measured and used in five definitions of overweight, including published cut-off points of BMI-for-age (Centers for Disease Control and Prevention BMI-for-age charts for boys and girls; BMI reference curves for the UK 1990; International Obesity Task Force age- and sex-specific BMI cut-offs), actual relative weight and BM > or =26 kg m(-2). Assessment of body image perceptions and satisfaction (using figure line drawings) was reported in a questionnaire specifically designed for this study. RESULTS: The prevalence of overweight within the total group differed between the four standard definitions of weight status, by 9% at baseline and 8% at follow-up. Accordingly, increasing trends over the year ranged from zero to 3%. Using the criterion BMI > or =26 kg m(-2), 6% of Dublin schoolchildren were overweight, compared with 1.9% of schoolchildren in 1990. Significantly more girls than boys were affected by fear of fatness and were trying to lose weight. CONCLUSION: A standard method for assessment of weight status is urgently needed for the evaluation of obesity prevention initiatives among Irish schoolchildren. Such initiatives need to be sensitive to the pervasiveness of fear of fatness among adolescent girls.  相似文献   

Behavioral responses of rats exposed to long-term dietary vinclozolin     

Flynn KM  Delclos KB  Newbold RR  Ferguson SA 《Journal of agricultural and food chemistry》2001,49(3):1658-1665

Vinclozolin is a fungicide used on food crops with human exposure estimated at approximately 2 microg/kg/day from ingestion; occupational exposure, however, may be greater. The metabolites of vinclozolin have been reported to act as antiandrogens and have adverse effects on reproductive physiology and behavior in animals. Here, pregnant rats were fed soy-free diets containing 0, 10, 150, or 750 ppm of vinclozolin (approximately 0, 0.8, 12, and 60 mg/kg/day for an adult) beginning on gestational day 7, and offspring were continued on these diets through sacrifice at postnatal day 77. Male and female offspring were assessed for changes in several nonreproductive sexually dimorphic behaviors: open field and running wheel locomotor activity, play behavior, and consumption of saccharin- and sodium chloride-flavored solutions. There was a significant interaction of sex with vinclozolin exposure on running wheel activity, which indicated that females in the high-dose exposure group were hypoactive compared to same-sex controls. There was a significant overall effect of vinclozolin exposure on fluid consumption, and high-dose animals showed increased intake of the saccharin solution and decreased intake of plain water while saccharin was available. Effects were more pronounced in females, which drank 40.8% more saccharin than control females, whereas males drank 6.2% more than control males. There were no effects of vinclozolin treatment on play behavior or sodium solution intake. Gestational duration, total and live pups per litter, litter sex ratios, and birth weight were also not significantly affected, nor were body weight and food intake for dams and offspring. These results indicate that long-term dietary exposure to vinclozolin does not have severe toxicological consequences on the nonreproductive behaviors measured here. However, exposure may cause subtle alterations in locomotor activity and consumption of saccharin-flavored solution.  相似文献