The effectiveness of the combined treatment of thrombocytic hemorrhagic diathesis of dogs with prednisolone and blood transfusion in the model of an aspirin-produced thrombocytopathy     

I Nolte  C Niemann  K Failing  G Müller-Berghaus 《Tier?rztliche Praxis》1988,16(4):417-422

The administration of 20 mg/kg of acetylsalicylic acid in 18 clinically healthy dogs resulted in a thrombocytopathy with lengthened capillary bleeding time and irreversible aggregation inhibition. Through the set up of individual dilution series, one could conclude the proportional percentage of aggregation functional transfused thrombocytes. The capillary bleeding time was shortened after the intravenous injection of prednisolone (5 mg/kg) without measurable influence on the thrombocytes. Compared to the singular use of cortisone or blood transfusion alone, the effect on capillary bleeding time became magnified when one combined transfusion and corticosteroids. The fresh blood conserves (12 hours) were, with respect to the haemostyptical properties, superior to blood stored for 5 days. The component of aggregation-functional thrombocytes was, due to the prophylactic cortisone application prior to transfusion, not increased.  相似文献   

A framework for evaluation of on-farm mastitis diagnostics in Australia     

RN Zadoks  E Scholz  SM Rowe  JM Norris  HB Pooley  J House 《Australian veterinary journal》2023,101(4):142-152

Numerous culture-based diagnostics are available on the Australian and international markets for on-farm detection of bacterial pathogens in milk. Use of such diagnostics may provide an opportunity to improve the prudent use of antimicrobials in udder health management. Farms are low-resource settings in terms of diagnostic microbiology capacity. The World Health Organisation has identified criteria for the evaluation of diagnostic tests in low resource settings based on Accuracy, Sensitivity, Specificity, User-friendliness, being Rapid or Robust, Equipment-free and being Deliverable (ASSURED). Here, we review how those criteria can be interpreted in the context of microbiological diagnosis of mastitis pathogens, and how on-farm diagnostics that are currently available in Australia perform relative to ASSURED criteria. This evaluation identifies multiple trade-offs, both with regard to scientific criteria and with regards to convenience criteria. More importantly, the purpose of testing may differ between farms, and test performance should be evaluated relative to its intended use. The ability of on-farm mastitis diagnostics to inform mastitis treatment decision-making in a timely and cost-effective manner depends not just on test characteristics but also on farm-specific pathogen prevalence, and on the farm enterprise's priorities and the farm manager's potential courses of action. With most assay evaluations to date conducted in professional laboratories, there is a surprising dearth of information on how well any of the diagnostic tests perform on-farm and, indeed, of the on-farm decision-making processes that they aim to inform.  相似文献   

EU regulatory aspects of resistance risk assessment     

Heimbach U  Kral G  Niemann P 《Pest management science》2002,58(9):935-938

The EPPO Standard PP 1/213(1) on resistance risk analysis is the basis for risk assessment within the authorisation process in Germany. Data for resistance risk analysis have to be provided by the applicant and risk-mitigation strategies prepared if necessary. The extent of data requirements and the intensity of the evaluation process depend mainly on the type of target organism, crop, mode of action of the active substance and the resistance history of the organism in combination with products of similar mode of action as the one being applied for. Because resistance risk is a very complicated issue during the authorisation of plant-protection products, intensive co-operation between applicants and regulators is essential prior to submission of the dossier, with due consideration of the amount of data necessary and, where required, the proposed resistance-management strategy.  相似文献   

Oxygen ions observed near Saturn's A ring     

Waite JH  Cravens TE  Ip WH  Kasprzak WT  Luhmann JG  McNutt RL  Niemann HB  Yelle RV  Mueller-Wodarg I  Ledvina SA  Scherer S 《Science (New York, N.Y.)》2005,307(5713):1260-1262

Ions were detected in the vicinity of Saturn's A ring by the Ion and Neutral Mass Spectrometer (INMS) instrument onboard the Cassini Orbiter during the spacecraft's passage over the rings. The INMS saw signatures of molecular and atomic oxygen ions and of protons, thus demonstrating the existence of an ionosphere associated with the A ring. A likely explanation for these ions is photoionization by solar ultraviolet radiation of neutral O2 molecules associated with a tenuous ring atmosphere. INMS neutral measurements made during the ring encounter are dominated by a background signal.  相似文献   

Reproductive Biotechnology: Prospects and Applications in the Herd Management of Sows*     

H. Niemann 《Reproduction in domestic animals》1991,26(1):22-26

Biotechnological procedures are valuable tools for an efficient reproductive management in a commercial pig production. Artificial insemination, puberty induction, estrus synchronization, early pregnancy diagnosis and induction of parturition are routinely used since years already and have significant impact for the herd management of sows. Embryo transfer (ET) can also be efficiently applied. But surgical procedures are required for the recovery and transfer of embryos. ET related biotechniques such as cryopreservation of ova and embryos, in vitro production of embryos, cloning and gene transfer are still at an experimental stage but will most likely gain significance shortly.  相似文献   

Gamete Intrafallopian Transfer (GIFT), an alternative to in vitro Fertilization Procedures for Special Applications     

D. Rath  H. Niemann  L. A. Johnson 《Reproduction in domestic animals》1994,29(4):349-350

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The preservation of the whole blood of dogs for transfusion purposes in CPDA-1 stabilizer-prepared PVC bags--the effect of storage on the count, the volume distribution and the ultrastructure of thrombocytes     

I Nolte  C Niemann  I K?ufer-Weiss  S K Bowry  G Müller-Berghaus 《Berliner und Münchener tier?rztliche Wochenschrift》1988,101(11):365-373

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Effects of genotype and environment on seed quality traits variability in interspecific cross-derived <Emphasis Type="Italic">Brassica</Emphasis> lines     

Janetta Niemann  Jan Bocianowski  Andrzej Wojciechowski 《Euphytica》2018,214(10):193

Genotype (G), environment [i.e. year (Y) and location (L)] and their interaction (GYL) play an important role in the final expression of quality attributes. A multi-environment trial in selected interspecific cross-derived Brassica lines was conducted to evaluate the magnitude of G, Y, L and GYL effects on seed quality traits of Brassica genotypes under three locations in Poland, during the 2011–2013 cropping season. The oil, protein, fiber (Acid Detergent Fiber and Neutral Detergent Fiber) as well as glucosinolate contents was determined by near-infrared reflectance spectroscopy (NIRS) and significant differences were observed between tested Brassica genotypes and across harvesting years and growing locations. Generally, all tested hybrid lines displayed wider genetic variability for studied quality traits than control genotypes. Analysis of variance indicated that the main effects of genotypes, years and locations as well as all interactions were significant for all traits of study (except year?×?location interaction for glucosinolates). However, location had the most significant effect on oil, protein and fiber content while genotype had significant impact on glucosinolates content in Brassica seeds. Moreover, the individual lines having combination of desirable traits were also identified from F₅ to F₇ generations of tested hybrids.  相似文献   

Expression of MHC-I and -II in Uterine Tissue from Early Pregnant Bitches     

S Schäfer-Somi  HB Beceriklisoy  I Walter  S Sabitzer  D Klein  H Kanca  D Kaya  AR Agaoglu  H &#;zgür  S Aslan 《Reproduction in domestic animals》2009,44(S2):103-108

The aim of the study was to investigate the expression of major histocompatibility complex (MHC)-I and -II in uterine tissues from pregnant and non-pregnant bitches, taken at different time periods after mating. The pregnant bitches were ovariohysterectomized during the pre-implantation (group 1, n = 4), implantation (group 2, n = 7) and placentation stage (group 3, n = 7). Non-pregnant animals in diestrus served as controls (group 4, n = 7). The expression of MHC- I and -II in salpinx, apex, middle horn, corpus uteri and at implantation sites was investigated by immunohistochemistry as well as qualitative and quantitative RT-PCR; MHC-I mRNA was detected in all tissues and with quantitative RT-PCR, and no significant changes were detected until placentation. Immunohistologically, at the apex and corpus site, the average number of MHC-II positive cells increased from the pre-implantation to the post-implantation stage (apex: 1.54 ± 1.21 to 3.82 ± 2.93; corpus: 1.62 ± 1.9 to 5.04 ± 4.95; p < 0.05). The greatest numbers of MHC-II positive cells were observed at placentation sites (6.64 ± 5.9). In parallel, a marked increase in the relative mRNA expression of MHC-II in uterine tissues was assessed from the pre-implantation to the placentation stage (relative to Glycerinaldehyd-3-phosphate-Dehydrogenase (GAPDH): 6.9 ± 9.5, 8.4 ± 5.8, p > 0.05). Immunohistologically, in the salpinx, significantly greater numbers of MHC-II positive cells were found in the tissues of pregnant animals than in the control group (p < 0.05). It is proposed that the increase in MHC-II is pregnancy-related, even though the impact on maintenance of canine pregnancy is still unclear.  相似文献   

Uterine Progesterone Receptor and Leukaemia Inhibitory Factor mRNA Expression in Canine Pregnancy     

S Schäfer-Somi  D Klein  HB Beceriklisoy  S Sabitzer  SS Ay  AR Agaoglu  I Kücükaslan  D Kaya  OA Aksoy  S Aslan 《Reproduction in domestic animals》2009,44(S2):109-114

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