Laboratory investigations in the “Lumpy Jaw” of macropods     

M. R. H. Taylor  P. Wilson  L. Smyth  L. English  C. T. Keane 《Veterinary research communications》1978,2(1):131-136

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Equine influenza: an update     

Smyth B 《Australian veterinary journal》2007,85(12):N14, N16

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Five cases of canine dysautonomia in England (2004 to 2006)     

Niessen SJ  Eastwood J  Smyth JB  Cherubini GB 《The Journal of small animal practice》2007,48(6):346-352

Canine dysautonomia was diagnosed definitively in five dogs by histopathology. All dogs were seen between June 2004 and July 2006 and originated from south-east England; four dogs originated from an urban area and one from a rural area. Of the urban dogs, one had recently visited Scotland and one had visited a kennel in a rural area nearby. Acute-onset but progressive vomiting, diarrhoea, depression and inappetence were the most common presenting clinical signs. Reduced or absent anal tone, dysuria, absence of pupillary light reflexes with intact vision, mydriasis, decreased corneal sensitivity and nictitating membrane protrusion were among the most frequent neurological findings. Abnormalities in pharmacological autonomic and physiological function testing (including orthostatic hypotension in two dogs) and diagnostic imaging studies were detected in some of the animals. All dogs failed to respond adequately to treatment, and given the poor prognosis, they were eventually euthanased. Histopathology identified marked chromatolysis of ganglion cell bodies. This case series emphasises that dysautonomia should be considered when a dog is presented in the UK with acute- or subacute-onset gastrointestinal signs and compatible physical and neurological abnormalities.  相似文献   

Immunogenicity of bovine parainfluenza type 3 virus proteins encapsulated in nanoparticle vaccines,following intranasal administration to mice   总被引：2，自引：0，他引：2  

Shephard MJ  Todd D  Adair BM  Po AL  Mackie DP  Scott EM 《Research in veterinary science》2003,74(2):187-190

Stimulation of long lasting, protective immunity to respiratory viruses is often difficult to achieve with conventional respiratory vaccines. Polymeric nanoparticles, incorporating viral proteins have been shown to offer sustained release of antigen, with consequent prolongued stimulation of the respiratory immune system. In this paper the efficacy of two nanoparticle vaccines (poly-lactide-co-glycolide, PLGA; polymethylmethacrylate, PMMA), incorporating proteins of bovine parainfluenza type 3 virus (BPI-3) was investigated. As a preliminary to experiments in calves, it was considered essential to demonstrate immunogenicity of the experimental vaccine in mice. Mice immunised with PLGA nanoparticles, containing BPI-3 proteins, developed higher levels of virus-specific antibody than mice immunised with the PMMA vaccine or with soluble viral proteins alone. Immunoblotting using serum from the vaccinated mice, demonstrated strong reactions against the major BPI-3 proteins.  相似文献   

Increased incidence of Streptococcus agalactiae     

Mackie D  Logan E 《The Veterinary record》2002,150(17):554-555

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Adenoviral infection of the renal interstitium of a lamb   总被引：1，自引：0，他引：1  

J A Smyth  S McConnell  P F Cush  B M Adair 《Veterinary pathology》1990,27(4):290-292

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Weak calf syndrome and parenteral selenium supplementation     

E F Logan  D A Rice  J A Smyth  W A Ellis 《The Veterinary record》1990,126(7):163-164

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Effect of creep feeding on structural and functional changes of the gut of early weaned pigs   总被引：4，自引：0，他引：4  

D Kelly  J A Smyth  K J McCracken 《Research in veterinary science》1990,48(3):350-356

Dose-dependent hypersensitivity responses mounted against antigenic constituents of creep feeds have been previously implicated in intestinal damage, digestive disorders and impaired performance of early weaned pigs. In the present study biochemical and histological investigations of the small intestine were undertaken to determine the putative relationship between creep feed level and hypersensitivity response in pigs weaned at 14 days. Creep feed was administered by gastric intubation and weaned pigs received the same diet by gastric intubation for five days. Mucosal structure and function at weaning were not affected by creep feeding regimen. Villus height decreased and crypt depth increased in weaned compared to suckled pigs, but morphology was unaffected by prior exposure to creep. Xylose absorption was not influenced by either creep feed level or weaning. Intraepithelial lymphocyte numbers increased during weaning but were not affected by the creep feeding regimen. Mucosal carbohydrase activity in weaned pigs was not significantly affected by preweaning treatment. The results do not support the hypothesis that post weaning changes in structure and function of the gut are related to creep feed level or to immune responses to dietary antigens.  相似文献   

Spatial and temporal evaluation of veterinarians and veterinary employers relative to human and domesticated animal populations in Australia 2002–2012          下载免费PDF全文

GB Smyth  IJ East  RM Wicks 《Australian veterinary journal》2015,93(5):137-144

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Treatment for FIV?     

N R Smyth  M Bennett  R M Goskell  A Brown  C J Gaskell 《The Veterinary record》1990,126(16):409-410

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