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Niessen SJ Eastwood J Smyth JB Cherubini GB 《The Journal of small animal practice》2007,48(6):346-352
Canine dysautonomia was diagnosed definitively in five dogs by histopathology. All dogs were seen between June 2004 and July 2006 and originated from south-east England; four dogs originated from an urban area and one from a rural area. Of the urban dogs, one had recently visited Scotland and one had visited a kennel in a rural area nearby. Acute-onset but progressive vomiting, diarrhoea, depression and inappetence were the most common presenting clinical signs. Reduced or absent anal tone, dysuria, absence of pupillary light reflexes with intact vision, mydriasis, decreased corneal sensitivity and nictitating membrane protrusion were among the most frequent neurological findings. Abnormalities in pharmacological autonomic and physiological function testing (including orthostatic hypotension in two dogs) and diagnostic imaging studies were detected in some of the animals. All dogs failed to respond adequately to treatment, and given the poor prognosis, they were eventually euthanased. Histopathology identified marked chromatolysis of ganglion cell bodies. This case series emphasises that dysautonomia should be considered when a dog is presented in the UK with acute- or subacute-onset gastrointestinal signs and compatible physical and neurological abnormalities. 相似文献
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In mature Merino rams, nutrition is one of the external cues that most strongly affects the reproductive centres of the preoptic-hypothalamic continuum. The signalling pathways that link dietary status and the activity of the neurones that produce gonadotrophin-releasing hormone signals are thought to be partly hormonal in nature to reflect the amount of body reserves. Among the hormones thought to be involved are insulin and leptin. This study tested whether recombinant bovine leptin infused (0.4 microg/h) into the third cerebral ventricle would stimulate pulsatile luteinizing hormone (LH) secretion in mature Merino rams when their energy status was low or decreasing, during both chronic (fasting) and acute reductions of energy balance. Leptin may interact with other hormones that depend on energy availability, so we also monitored changes in circulating concentrations of insulin, thyroid hormones, growth hormone, prolactin and adrenocorticotrophin. Overall, our data do not support this hypothesis. The dietary regimes induced clear responses in the metabolic profiles of the animals but there was no clear effect of central leptin administration on LH pulse frequency. The relationships between the hormonal systems measured in the present study add weight to the contention that leptin plays only a permissive role in the nutritional control of the reproductive axis and that other hormonal signals (particularly insulin) or pathways are acting in concert with leptin to stimulate the reproductive axis. 相似文献
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Adenoviral infection of the renal interstitium of a lamb 总被引:1,自引:0,他引:1
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Effect of creep feeding on structural and functional changes of the gut of early weaned pigs 总被引:4,自引:0,他引:4
Dose-dependent hypersensitivity responses mounted against antigenic constituents of creep feeds have been previously implicated in intestinal damage, digestive disorders and impaired performance of early weaned pigs. In the present study biochemical and histological investigations of the small intestine were undertaken to determine the putative relationship between creep feed level and hypersensitivity response in pigs weaned at 14 days. Creep feed was administered by gastric intubation and weaned pigs received the same diet by gastric intubation for five days. Mucosal structure and function at weaning were not affected by creep feeding regimen. Villus height decreased and crypt depth increased in weaned compared to suckled pigs, but morphology was unaffected by prior exposure to creep. Xylose absorption was not influenced by either creep feed level or weaning. Intraepithelial lymphocyte numbers increased during weaning but were not affected by the creep feeding regimen. Mucosal carbohydrase activity in weaned pigs was not significantly affected by preweaning treatment. The results do not support the hypothesis that post weaning changes in structure and function of the gut are related to creep feed level or to immune responses to dietary antigens. 相似文献
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