Phylogenetic analysis of Myanmar indigenous chickens using mitochondrial D-loop sequence reveals their characteristics as a genetic resource     

Su Lai Yee Mon  Moe Lwin  Aye Aye Maw  Lat Lat Htun  Saw Bawm  Kotaro Kawabe  Yasuhiko Wada  Shin Okamoto  Takeshi Shimogiri 《Animal Science Journal》2021,92(1):e13647

Myanmar indigenous chickens play important roles in food, entertainment, and farm business for the people of Myanmar. In this study, complete mitochondrial D-loop sequences (1232 bp) were analyzed using 176 chickens, including three indigenous breeds, two fighting cock populations, and three indigenous populations to elucidate genetic diversity and accomplish a phylogenetic analysis of Myanmar indigenous chickens. The average haplotype and nucleotide diversities were 0.948 ± 0.009 and 0.00814 ± 0.00024, respectively, exhibiting high genetic diversity of Myanmar indigenous chickens. Sixty-four haplotypes were classified as seven haplogroups, with the majority being haplogroup F. The breeds and populations except Inbinwa had multiple maternal haplogroups, suggesting that they experienced no recent purifying selection and bottleneck events. All breeds and populations examined shared haplogroup F. When 232 sequences belonging to haplogroup F (79 from Myanmar and 153 deposited sequences from other Asian countries/region) were analyzed together, the highest genetic diversity was observed in Myanmar indigenous chickens. Furthermore, Myanmar indigenous chickens and red junglefowls were observed in the center of the star-like median-joining network of 37 F-haplotypes, suggesting that Myanmar is one of the origins of haplogroup F. These findings revealed the unique genetic characteristic of Myanmar indigenous chickens as important genetic resources.  相似文献   

Cloning and characterization of chicken growth hormone binding protein (cGHBP)     

Lau JS  Yip CW  Law KM  Leung FC 《Domestic animal endocrinology》2007,33(1):107-121

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Distribution and habitat characteristics of three sympatric cetacean species in the coastal waters of Matang,Perak, Peninsular Malaysia     

Sui Hyang Kuit  Louisa Shobhini Ponnampalam  Jol Ern Ng  Ving Ching Chong  Amy Yee‐Hui Then 《水产资源保护:海洋与淡水生态系统》2019,29(10):1681-1696

Evaluation of Selected Cytokine Gene Expression in Colonic Mucosa from Dogs with Idiopathic Lymphocytic-plasmacytic Colitis     

Yu TAMURA  Hiroshi OHTA  Nozomu YOKOYAMA  Sue Yee LIM  Tatsuyuki OSUGA  Keitaro MORISHITA  Kensuke NAKAMURA  Masahiro YAMASAKI  Mitsuyoshi TAKIGUCHI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2014,76(10):1407-1410

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Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts     

Chiu PY  Lam PY  Yan CW  Ko KM 《Fitoterapia》2011,82(4):682-691

The effects of schisandrin B (Sch B) and its analogs on solar irradiation-induced oxidative injury were examined in BJ human fibroblasts. Sch B and schisandrin C (Sch C) increased cellular reduced glutathione (GSH) level and protected against solar irradiation-induced oxidative injury. The photoprotection was paralleled by decreases in the elastases-type protease activity and matrix-metalloproteinases-1 expression in solar-irradiated fibroblasts. The cytochrome P-450-mediated metabolism of Sch B or Sch C caused ROS production. The results suggest that by virtue of its pro-oxidant action and the subsequent glutathione antioxidant response, Sch B or Sch C may offer the prospect of preventing skin photo-aging.  相似文献   

A liver-specific enhancer in the core promoter region of human hepatitis B virus   总被引：33，自引：0，他引：33  

J K Yee 《Science (New York, N.Y.)》1989,246(4930):658-661

An 88-base pair fragment in the core promoter of the human hepatitis B virus (HBV) contains a functional promoter and a strong liver-specific enhancer. This enhancer functions in human hepatoma cells, where it is much more active than the previously described HBV enhancer in stimulating expression of the linked bacterial chloramphenicol acetyltransferase gene expressed from heterologous promoters. Studies of the role of this enhancer-promoter in HBV may help to clarify mechanisms of gene expression in cells infected with HBV and the role of the virus in the pathogenesis of hepatitis and hepatocellular carcinoma.  相似文献   

Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization   总被引：34，自引：0，他引：34  

C P Hill  J Yee  M E Selsted  D Eisenberg 《Science (New York, N.Y.)》1991,251(5000):1481-1485

Defensins (molecular weight 3500 to 4000) act in the mammalian immune response by permeabilizing the plasma membranes of a broad spectrum of target organisms, including bacteria, fungi, and enveloped viruses. The high-resolution crystal structure of defensin HNP-3 (1.9 angstrom resolution, R factor 0.19) reveals a dimeric beta sheet that has an architecture very different from other lytic peptides. The dimeric assembly suggests mechanisms by which defensins might bind to and permeabilize the lipid bilayer.  相似文献   

Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells   总被引：80，自引：0，他引：80  

H J Huang  J K Yee  J Y Shew  P L Chen  R Bookstein  T Friedmann  E Y Lee  W H Lee 《Science (New York, N.Y.)》1988,242(4885):1563-1566

Mutational inactivation of the retinoblastoma susceptibility (RB) gene has been proposed as a crucial step in the formation of retinoblastoma and other types of human cancer. This hypothesis was tested by introducing, via retroviral-mediated gene transfer, a cloned RB gene into retinoblastoma or osteosarcoma cells that had inactivated endogenous RB genes. Expression of the exogenous RB gene affected cell morphology, growth rate, soft agar colony formation, and tumorigenicity in nude mice. This demonstration of suppression of the neoplastic phenotype by a single gene provides direct evidence for an essential role of the RB gene in tumorigenesis.  相似文献   

Ultrafast flash thermal conductance of molecular chains     

Wang Z  Carter JA  Lagutchev A  Koh YK  Seong NH  Cahill DG  Dlott DD 《Science (New York, N.Y.)》2007,317(5839):787-790

At the level of individual molecules, familiar concepts of heat transport no longer apply. When large amounts of heat are transported through a molecule, a crucial process in molecular electronic devices, energy is carried by discrete molecular vibrational excitations. We studied heat transport through self-assembled monolayers of long-chain hydrocarbon molecules anchored to a gold substrate by ultrafast heating of the gold with a femtosecond laser pulse. When the heat reached the methyl groups at the chain ends, a nonlinear coherent vibrational spectroscopy technique detected the resulting thermally induced disorder. The flow of heat into the chains was limited by the interface conductance. The leading edge of the heat burst traveled ballistically along the chains at a velocity of 1 kilometer per second. The molecular conductance per chain was 50 picowatts per kelvin.  相似文献   

An extension of the Lin-Yip estimator for continuous-time capture studies     

Yan Wang  Paul S. F. Yip 《Journal of Agricultural, Biological & Environmental Statistics》2002,7(4):574-585

A unified approach is suggested to estimate the population size for continuous time capture studies with possible removals during the capture process. It extends and improves the Lin-Yip estimator. The usual recaptureand removal models can be shown to be particular cases of the general formulation. A Horvitz-Thompson procedure is used to estimate the population size based on the estimated capture probabilities. The resultant estimators for the regression parameters and population size are consistent and asymptotically normal underappropriateregularity conditions. We assess the properties of the proposed estimators through Monte Carlo simulation. Two examples are given.  相似文献