排序方式： 共有2条查询结果，搜索用时 15 毫秒
1
1.
近年来,因食用织纹螺(Nassariusspp.)导致的中毒事件在中国沿海屡有发生。由于中毒患者的症状与麻痹性贝毒中毒症状相似,因此,许多中毒事件被归咎于麻痹性贝毒,认为织纹螺中的毒素与邻近海域的有毒赤潮有关,但也有研究发现螺体内存在河豚毒素。对此,本研究应用亲水性相互作用色谱柱建立了河豚毒素的液相色谱-质谱联用分析方法,对造成2002年和2003年两次中毒事件的织纹螺样品进行分析。结果表明,两批织纹螺样品中均含有高浓度的河豚毒素及其衍生物,包括三脱氧河豚毒素、脱水河豚毒素和单加氧河豚毒素等,而且两个织纹螺样品中的毒素组成非常相似。因此,导致这两起中毒事件的致毒因子是河豚毒素及其衍生物。江苏和福建两地织纹螺中毒素组成的相似性显示两地织纹螺可能具有相同或相近的毒素来源。 相似文献
2.
A Cl(7) component of technical toxaphene (CTT), previously detected in marine mammals and fish and referred to as "7-1", was isolated from contaminated estuarine sediment using preparative solid-liquid chromatography followed by reversed-phase HPLC. The structure of this compound, elucidated by GC/MS and (1)H NMR, was 2-endo,3-exo,5-endo,6-exo,8,8,10-heptachlorobornane (hereafter referred to as B7-1000). This newly identified CTT eluted in the nonpolar fraction from silica and shares the alternating endo-exo chlorine substitution pattern with other relatively nonpolar, persistent congeners (e.g., B8-1413 and B9-1679). Based on ECNI-MS response, levels of B7-1000 in tissue samples of various higher organisms including humans were as high as 16% of B8-1413. Enantioselective determination of B7-1000 using a modified cyclodextrin chiral stationary phase (beta-BSCD) resulted in enantiomer ratios that were depleted in adipose tissue of a marine bird (skua) and Weddell seal blubber (0.3 and 0.5, respectively), but not in elephant seal blubber (1.1). Elucidation of the structure of B7-1000 thus validates previous predictions of persistence based on structure-activity relationships, chromatographic properties, and molecular modeling. 相似文献
1