Relationship between anti-insulin antibody production and severe insulin resistance in a diabetic cat     

Takumi KOMIYA  Akihiro MORI  Naohito NISHII  Hitomi ODA  Eri ONOZAWA  Seri SEKI  Toshinori SAKO 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(4):661

A 5-year-old castrated male domestic shorthair cat was diagnosed with diabetic ketoacidosis and severe insulin resistance. Although the conventional treatment for diabetic ketoacidosis was provided, the cat required frequent hospitalization because of severe dehydration and repeated diabetic ketoacidosis. We detected anti-insulin antibodies for human in this cat. Serum insulin-binding IgG levels were markedly elevated compared with those in healthy cats and other diabetic cats. We initiated prednisolone to suppress the effects of anti-insulin antibodies. After initiation of prednisolone, the cat was gradually recovered with increasing activity and appetite. Furthermore, satisfactory glycemic control was achieved with combined subcutaneous injection of insulin detemir and insulin degludec.  相似文献   

Genetic variants of the unsaturated fatty acid receptor GPR120 relating to obesity in dogs     

Masahiro MIYABE  Azusa GIN  Eri ONOZAWA  Mana DAIMON  Hana YAMADA  Hitomi ODA  Akihiro MORI  Yutaka MOMOTA  Daigo AZAKAMI  Ichiro YAMAMOTO  Mariko MOCHIZUKI  Toshinori SAKO  Katsutoshi TAMURA  Katsumi ISHIOKA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(10):1201-1206

G protein-coupled receptor (GPR) 120 is an unsaturated fatty acid receptor, which is associated with various physiological functions. It is reported that the genetic variant of GPR120, p.Arg270His, is detected more in obese people, and this genetic variation functionally relates to obesity in humans. Obesity is a common nutritional disorder also in dogs, but the genetic factors have not ever been identified in dogs. In this study, we investigated the molecular structure of canine GPR120 and searched for candidate genetic variants which may relate to obesity in dogs. Canine GPR120 was highly homologous to those of other species, and seven transmembrane domains and two N-glycosylation sites were conserved. GPR120 mRNA was expressed in lung, jejunum, ileum, colon, hypothalamus, hippocampus, spinal cord, bone marrow, dermis and white adipose tissues in dogs, as those in mice and humans. Genetic variants of GPR120 were explored in client-owned 141 dogs, resulting in that 5 synonymous and 4 non-synonymous variants were found. The variant c.595C>A (p.Pro199Thr) was found in 40 dogs, and the gene frequency was significantly higher in dogs with higher body condition scores, i.e. 0.320 in BCS4–5 dogs, 0.175 in BCS3 dogs and 0.000 in BCS2 dogs. We conclude that c.595C>A (p.Pro199Thr) is a candidate variant relating to obesity, which may be helpful for nutritional management of dogs.  相似文献   

Preliminary Study Characterizing the Use of Sitagliptin for Glycemic Control in Healthy Beagle Dogs with Normal Gluco-Homeostasis     

Hitomi ODA  Akihiro MORI  Peter LEE  Kaori SAEKI  Toshiro ARAI  Toshinori SAKO 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2014,76(10):1383-1387

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The Silicon Concentration in Cat Urine and Its Relationship with Other Elements     

Fumihito TAKAHASHI  Mariko MOCHIZUKI  Takuya YOGO  Katsumi ISHIOKA  Norio YUMOTO  Toshinori SAKO  Fukiko UEDA  Masahiro TAGAWA  Hiroyuki TAZAKI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2014,76(4):569-572

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Is experience on a farm an effective approach to understanding animal products and the management of dairy farming?     

Mariko Mochizuki  Masahiro Osada  Katsumi Ishioka  Takako Matsubara  Yutaka Momota  Norio Yumoto  Toshinori Sako  Shinji Kamiya  Itaru Yoshimura 《Animal Science Journal》2014,85(3):323-329

The understanding of animal products and dairy farming is important for the promotion of dairy farming. Thus, to examine the effects of farm experience on the understanding of animal products and the management of dairy farming, the interaction between students and dairy cows was investigated in groups of first‐year veterinary nursing students in 2011 and 2012 (n = 201). These students included 181 women and 20 men. Nine items about dairy cows were presented in a questionnaire. The survey was performed before and after praxis on the educational farm attached to the authors' university. After praxis on the farm, increases occurred in the number of positive responses to the items involving the price of milk, dairy farming and the taste of milk. For these items, a significant difference (P < 0.05) was found between the scores obtained before and after training. The results of the study suggested that farm experience is useful for improving the understanding of animal products and dairy farming.  相似文献   

微波干燥稻谷和糙米的能量效率     

董铁有  木村俊范  吉崎繁  川上友晖 《农业工程学报》2002,18(5):43-47

对厚层及均匀平铺载荷条件下稻谷和糙米的微波干燥过程中的能量效率问题进行了研究。根据本研究的实验数据,如果干燥方法和工艺安排合理,微波干燥稻谷和糙米可达到较高的能量效率,甚至可达到高于传统干燥方法。在微波干燥过程中安排一定的间歇时间以发挥照射后期作用、间歇照射作用或缓苏作用,可以有效地提高微波干燥过程中的能量效率。有2h间歇的干燥工艺的能量效率是没有间歇的干燥工艺的能量效率的5倍。载荷形式对微波干燥过程中的能量效率影响也较大。微波干燥中建议采用薄层载荷形式。  相似文献   

Malignant Peritoneal Mesothelioma with a Sarcomatoid Growth Pattern and Signet-Ring-Like Structure in a Female F344 Rat     

Aya Ohnuma-Koyama  Toshinori Yoshida  Naofumi Takahashi  Satoshi Akema  Yukiko Takeuchi-Kashimoto  Maki Kuwahara  Mika Nagaike  Kosei Inui  Nobuaki Nakashima  Takanori Harada 《Journal of toxicologic pathology》2013,26(2):197-201

We report a biphasic malignant mesothelioma in an aged female F344/DuCrlCrlj rat. Macroscopically, multiple pale brown nodules were observed in the abdominal cavity with retention of bloody ascites. Histopathologically, the tumor cells spread over the peritoneum and formed masses on the surface and underlying adipose tissues. The tumor cells dominantly proliferated in a solid, nodular or nest-like pattern with modest amount of fibrillar connective tissues, which contained hyaluronan. The tumor consisted of ovoid, polygonal or spindle-shaped cells that possessed eosinophilic cytoplasms including glycogen; some tumor cells showed a signet-ring-like structure. Multinucleated cells and mitosis were found frequently, and direct invasion to intra-abdominal organs and intravascular metastasis to the liver were observed. Immunohistochemically, keratin and mesothelin were strongly positive in most of tumor cells, while vimentin was mainly positive in spindle-shaped cells. Podoplanin was also positive, particularly in the cell membrane of tumor cells. Electron microscopically, tumor cells showed an intercellular desmosome-like structure, basement membrane and microvillus. We diagnosed the case as a malignant peritoneal mesothelioma with a sarcomatoid growth pattern and signet-ring-like structure.  相似文献   

Comparison of cholesterol levels among lipoprotein fractions separated by anion-exchange high-performance liquid chromatography in periparturient Holstein–Friesian dairy cows     

Tomoya TAKAHASHI  Akihiro MORI  Hitomi ODA  Isao MURAYAMA  Mitsuhiko KOUNO  Toshinori SAKO 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(2):260

Changes in lipoprotein profiles occur in dairy cows during the periparturient period and in cows with transition cow disease. Here, the lipoprotein profiles of Holstein–Friesian dairy cows during the periparturient period were obtained by anion-exchange, high-performance liquid chromatography to evaluate the usefulness of lipoprotein profile evaluation during the periparturient period and in cows with fatty liver and milk fever. Lipoprotein levels (including total and high- (HDL-C) and low-density lipoprotein (LDL-C) cholesterol) in 10 healthy cows were low 4 weeks prepartum, with the lowest values at calving or within 1 week of calving; the values increased at 8 weeks postpartum. The lipoprotein levels were measured in 16 cows diagnosed with fatty liver (n=10) or milk fever (n=6) and compared to 10 healthy dairy cows. A significant difference was observed in HDL-C between healthy cows (at calving and 1 week postpartum), and the fatty liver and milk fever cows. Cows with fatty liver and milk fever had a lower mean HDL-C than the 10 healthy dairy cows at calving and 1 week postpartum. HDL-C might be a good indicator of energy balance for differentiating healthy cows from those with transition cow disease.  相似文献   

Characterization of the morphological and physiological traits of rice cultivars with adaptation to unflooded condition during early vegetative growth     

Maya Matsunami  Toshinori Matsunami  Ikuko Kodama  Atsushi Ogawa  Kyoko Toyofuku  Junko Ishikawa－Sakurai 《Plant Production Science》2016,19(1):173-180

This study aimed to characterize the physiological and morphological traits that are associated with adaptation to unflooded soil conditions in rice. Four indica rice cultivars (Puluik Arang, Badari Dhan, Shwe Nang Gyi, and Ratul), which were previously identified as highly or less adaptable to unflooded soil conditions, were grown under flooded and unflooded (soil water potential; －0.10 MPa) soil conditions. Water uptake was measured every day for three weeks, and then the leaf water potential, the stomatal conductance, the dry matter weight, shoot and root morphological traits were measured. Puluik Arang and Badari Dhan exhibited greater leaf area expansion and higher maintenance of root development under the unflooded condition than that by other cultivars. The leaf water potential and stomatal conductance of fully expanded highest leaf in Puluik Arang and Badari Dhan were not affected by unflooded soil regime. Leaf area and root morphological traits were significantly correlated with water uptake regardless of soil moisture regimes. These results suggested that Puluik Arang and Badari Dhan exhibited great water uptake capacity through physiological and morphological adaptation of shoot and root traits to unflooded condition, resulting in great biomass productivity under the condition.  相似文献   

两种功能高分子材料对沙土物理性质影响的比较   总被引：1，自引：0，他引：1  

王勇  王龙昌  小岛纪德 《干旱地区农业研究》2008,26(5):94-99

采用SEM,透水系数法、加压板法等现代测试手段,观察与分析高分子吸水树脂、固沙植被多功能高分子复合材料表面微观结构形态,比较高分子吸水树脂与固沙植被多功能高分子复合材料改良沙土后沙土的透水、保水等特性及沙土水分的有效利用情况.实验结果证明固沙植被多功能高分子复合材料比高分子吸水树脂改良沙土的效果好,使沙土的气、液、固三相比有利植物的生长,能保持高的水有效利用率.本实验结果为固沙植被多功能高分子复合材料的应用提供了新的依据.  相似文献