Endogenous opiates and stress-induced eating     

Morley JE  Levine AS 《Science (New York, N.Y.)》1981,214(4525):1150-1151

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Removal of hemangiosarcoma cells from canine blood with a cell salvage system and leukocyte reduction filter          下载免费PDF全文

Brittany Ciepluch DVM  MS  Heather Wilson‐Robles DVM  DACVIM  Gwendolyn Levine DVM  DACVP  Roger Smith DVM  PhD  Gus A. Wright PhD  Tasha Miller BS  Maureen T. O'Brien DVM  MS  DACVP  Kelley M. Thieman Mankin DVM  MS  DACVS‐SA 《Veterinary surgery : VS》2018,47(2):293-301

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The 5‐lipoxygenase inhibitor tepoxalin induces oxidative damage and altered PTEN status prior to apoptosis in canine osteosarcoma cell lines          下载免费PDF全文

J. P. Loftus  D. Cavatorta  J. J. Bushey  C. B. Levine  C. S. Sevier  J. J. Wakshlag 《Veterinary and comparative oncology》2016,14(2):e17-e30

The 5‐lipoxygenase (5‐LOX) inhibitor tepoxalin has been shown to slow canine osteosarcoma (OSA) tumour xenografts growth, yet the mechanisms are poorly elucidated. Further examination of tepoxalin in canine OSA cell lines shows that tepoxalin treated cells undergo apoptosis through caspase‐3 activation and annexin staining. Interestingly, apoptosis is superseded by an increase in reactive oxygen species (ROS), as measured by activation of dihydrorhodamine 123 and mitosox. This increase in ROS appears to be related to the 5‐LOX inhibitor regardless of cellular 5‐LOX status, and was not observed after treatment with the tepoxalin metabolite RWJ20142. Additionally, 5‐LOX inhibition by tepoxalin appears to increase phosphatase and tensin (PTEN) homolog activity by preventing its alkylation or oxidation. PTEN modification or inhibition allows phosphoinositide‐3 (PI3) kinase activity thereby heightening activation of protein kinase B (AKT) phosphorylation. Our data suggest that off target oxidation and LOX inhibition play roles in the apoptotic response.  相似文献   

A comparison of clinical,magnetic resonance imaging and pathological findings in dogs with gliomatosis cerebri,focusing on cases with minimal magnetic resonance imaging changes‡          下载免费PDF全文

R. T. Bentley  G. N. Burcham  H. G. Heng  J. M. Levine  R. Longshore  S. Carrera‐Justiz  K. Kopf  M. A. Miller 《Veterinary and comparative oncology》2016,14(3):318-330

The primary study objective was to determine whether clinical examination and magnetic resonance imaging (MRI) can underestimate canine gliomatosis cerebri (GC); we also investigated immunohistochemical features. Seven dogs with GC were studied; four recruited specifically because of minimal MRI changes. Neuroanatomic localization and the distribution of MRI, gross and sub‐gross lesions were compared with the actual histological distribution of neoplastic cells. In six cases, clinical examination predicted focal disease and MRI demonstrated a single lesion or appeared normal. Neoplastic cells infiltrated many regions deemed normal by clinical examination and MRI, and were Olig2‐positive and glial fibrillary acid protein‐negative. Four dogs had concurrent gliomas. GC is a differential diagnosis for dogs with focal neurological deficits and a normal MRI or a focal MRI lesion. Canine GC is probably mainly oligodendrocytic. Type II GC, a solid glioma accompanying diffuse central nervous system neoplastic infiltration, occurs in dogs as in people.  相似文献   

Retrospective Evaluation of Horses Diagnosed with Neuroborreliosis on Postmortem Examination: 16 Cases (2004–2015)          下载免费PDF全文

L.K. Johnstone  J.B. Engiles  H. Aceto  V. Buechner‐Maxwell  T. Divers  R. Gardner  R. Levine  N. Scherrer  D. Tewari  J. Tomlinson  A.L. Johnson 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2016,30(4):1305-1312

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Theory of mind is independent of episodic memory     

Rosenbaum RS  Stuss DT  Levine B  Tulving E 《Science (New York, N.Y.)》2007,318(5854):1257

Theory of mind (ToM) to infer other people's current mental states and episodic memory of personal happenings have been assumed to be closely related. We report two participants with severely impaired episodic memory who perform indistinguishably from healthy controls on objective ToM tests. These results suggest that ToM can function independently of episodic memory.  相似文献   

Suspected panosteitis in a camel     

Levine DG  Smith JJ  Richardson DW  Brown V  Beech J  Habecker P  Adam E 《Journal of the American Veterinary Medical Association》2007,231(3):437-441

CASE DESCRIPTION: A 6-month-old male Bactrian camel was examined because of a 3-week history of lameness of the left hind limb. CLINICAL FINDINGS: Lameness was initially detected in the left hind limb but resolved and was detected in the right hind limb during treatment. Lameness increased during periods of rapid growth. Radiography revealed multiple small opacities of the medullary cavity of several long bones throughout treatment. Core bone biopsies of lesions in the tibiae revealed lamellar bone with areas of loose connective tissue, osteoblasts in the medullary cavity, and periosteal new bone formation, all which were consistent with panosteitis. TREATMENT AND OUTCOME: Palliative treatment was attempted with epidural and transdermal administration of analgesics. Flunixin meglumine was administered PO, which coincided with an abrupt increase in serum creatinine concentration. Performance of multiple diagnostic bone biopsies led to remission of clinical signs of pain. CLINICAL RELEVANCE: Panosteitis should be a differential diagnosis for shifting limb lameness in young camels. Bone biopsies can be useful for diagnosis of panosteitis and possible relief of pain associated with the disease. Bactrian camels may be susceptible to the renal toxicity of flunixin meglumine, especially when dehydrated.  相似文献   

Requirements for the successful introduction and management of rotational irrigation     

G. Levine  L. T. Chin  S. M. Miranda 《Agricultural Water Management》1976,1(1):41-56

This paper attempts to identify the critical elements associated with the introduction and management of the practice of Rotational Irrigation in Taiwan, and thus to shed some light on the basic requirements for its successful adoption. While the emphasis is on this specific practice we believe it has implications for the transfer of other technologies in which physical, biological and managerial factors interact importantly.Seven irrigation associations in Taiwan were studied to identify the external conditions and system characteristics that are necessary for a successful change from continuous to rotational irrigation. Three external essentials are identified: (1) a water deficit approximating 25 percent of normal practice in the area; (2) political commitment to the change; (3) adequate financial resources for implementation and subsequent operation. Two system characteristics considered essential are: (1) physical facilities that provide for control and measurement to the level of farmer group responsibility; and (2) management patterns that provide a well-organized operating group and effective communication between the farmers and system personnel, resulting in a responsive plan of operation.Specific adaptations of the Taiwan practices to the local conditions will be necessary before effective transfer of this technology can take place elsewhere.  相似文献   

Review and analysis of the potential for glyphosate to interact with the estrogen,androgen and thyroid pathways     

Steven L Levine  Elizabeth G Webb  David A Saltmiras 《Pest management science》2020,76(9):2886-2906

Glyphosate was recently evaluated for its potential to interact with the estrogen, androgen and thyroid (EAT) hormone pathways, including steroidogenesis, under the United States Environmental Protection Agency's (USEPA) Endocrine Disruptor Screening Program (EDSP), then by Germany, the rapporteur Member State who led the European Annex 1 renewal for glyphosate, and then by the European Food Protection Agency (EFSA) also as part of the Annex 1 renewal for glyphosate. Under the EDSP, 11 Tier 1 assays were run following the USEPA's validated 890‐series test guidelines and included five in vitro and six in vivo assays to evaluate the EAT pathways. Steroidogenesis was evaluated as part of the estrogen and androgen pathways. An up‐to‐date critical review has been conducted that considered results from the EDSP Tier 1 battery, guideline regulatory studies and an in‐depth analysis of the literature studies that informed an endocrine assessment. A strength of this evaluation was that it included data across multiple levels of biological organization, and mammalian and nonmammalian test systems. There was strong agreement across the in vitro and in vivo Tier 1 battery, guideline studies and relevant literature studies, demonstrating that glyphosate does not interact with EAT pathways including steroidogenesis. Based on an analysis of the comprehensive toxicology database for glyphosate and the literature, this review has concluded that glyphosate does not have endocrine‐disrupting properties through estrogen, androgen, thyroid and steroidogenic modes of action. © 2020 Society of Chemical Industry  相似文献   

Ellipsosomes: organelles containing a cytochrome-like pigment in the retinal cones of certain fishes   总被引：1，自引：0，他引：1  

E F MacNichol  Y W Kunz  J S Levine  F I Hárosi  B A Collins 《Science (New York, N.Y.)》1978,200(4341):549-552

Ellipsosomes are dense spherical bodies containing a very large concentration of a heme pigment spectroscopically resembling pure cytochrome c. They are located at the outer ends of the inner segments of the cones of certain fishes. Although, superficially, they resemble the similarly located oil droplets in the cones of birds and reptiles, their ultrastructure and staining properties resemble those of the neighboring mitochondria. However, like the oil droplets, they may serve as intracellular color filters.  相似文献