Actinomycin D for Reinduction of Remission in Dogs With Resistant Lymphoma     

Anthony S. Moore BVSc  MVSc    Gregory K. Ogilvie  David M. Vail 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1994,8(5):343-344

Twenty-five dogs with malignant lymphoma refractory to chemotherapy were treated with actinomycin D at a median dose of 0.7 mg/m² (range, 0.5 to 0.9 mg/m²) every 3 weeks. The dogs treated had received between 2 and 8 chemotherapeutic agents (median 7), for a median of 266 days before being treated with actinomycin D. For 23 of the 25 dogs, previous chemotherapy included doxorubicin. No dog responded to actinomycin D chemotherapy.  相似文献   

ULTRASONOGRAPHY OF ALIMENTARY LYMPHOSARCOMA IN THE CAT     

Dominique G.  Penninck  DVM  Antony S.  Moore  BVSc  MVSc  Amy S.  Tidwell  DVM  Michael E.  Matz  DVM  Greg O.  Freden  DVM 《Veterinary radiology & ultrasound》1994,35(4):299-306

Clinical, radiological and ultrasonographic findings from 22 cats with gastrointestinal lymphosarcoma were reviewed. The most common clinical findings were anorexia, weight loss, vomiting, lethargy, depression, fever, anemia and a palpable abdominal mass. Abdominal radiographs of 12 cats revealed a mass associated with the gastrointestinal tract and/or mesentery, and decreased serosal detail, suggestive of peritoneal effusion. The most common ultrasonographic finding was transmural gastric or intestinal thickening associated with loss of normal wall layering, reduced wall echogenicity and localized hypomotility. As is noted in people, other patterns such as transmural-segmental, transmural-nodular, transmural-bulky and mucosal infiltration were represented. In 3 cats, mesenteric lymph-adenopathy was responsible for most of the mass-effect. Fine-needle aspiration biopsy, automated microcore biopsy, endoscopic biopsy or necropsy confirmed the diagnosis of lymphosarcoma in all cats. Chemotherapy was instituted in 19 cats. Only 6 cats had a complete response to treatment. The results of this study indicate that ultrasonography is a valuable tool for the diagnosis of feline alimentary lymphosarcoma and that biopsies can be obtained under ultrasonographic guidance.  相似文献   

RADIOGRAPHIC DIAGNOSIS: INTRAMEDULLARY EXTRUSION OF AN INTERVERTEBRAL DISC     

Julius M.  Liptak  BVSc  MvetClinstud  MACVSc  Graeme S.  Allan  MVSc  FACVSc  Mark B.  Krockenberger  BSc  BVSc  Phillip E.  Davis  MVSc  Richard  Malik  BVSc  MvetClinStud  PhD  FACVSc 《Veterinary radiology & ultrasound》2002,43(3):272-274

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Intracavitary Cisplatin Chemotherapy Experience with Six Dogs   总被引：1，自引：0，他引：1  

Antony S. Moore MVSc    Claudia Kirk DVM  Aglaia Cardona DVM 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1991,5(4):227-231

Six dogs with a median age of 7 years (range = 5-14 years) were presented for signs referable to thoracic or abdominal effusion associated with neoplasia of the body cavities. Intracavitary cisplatin was administered at 50 mg/m2 every 4 weeks for a median of 2.5 treatments (mean = 3, range = 1-6). Three dogs with pleural mesothelioma had complete resolution of effusion for 289, 129, and greater than 306 days without evidence of tumor growth. Resolution of effusion occurred after one treatment in two dogs and after two treatments in one dog. In three dogs with carcinomatosis of unknown origin, complete responses was seen in two dogs after one treatment for 255 and greater than 807 days, respectively. Intracavitary chemotherapy with cisplatin was associated with palliation and control of malignant pleural and/or abdominal effusion in five of six dogs. Toxicity was minimal, and this method of therapy should be further explored in dogs with similar malignancies.  相似文献   

Replication of turkey herpesvirus and Marek's disease virus in chick embryo skin organ culture.     

L B Prasad 《Research in veterinary science》1979,27(1):82-88

Turkey herpesvirus (HVT) and an attenuated Marek's disease virus (MDV) replicated in organ cultures of chick embryo skin as assessed by immunofluorescence and/or electron microscopy. HVT-specific immunofluorescent antigen was detected in the feather follicle epithelium (FFE) and in the surface layer of the skin epidermis. Electron microscopy of infected explants revealed herpes-type cytopathology. Immature particles of both viruses appeared first in the nucleus. Oval or horseshoe-shaped non-enveloped particles of HVT and enveloped virions of MDV were seen in the cytoplasm of some transitional cells. The difference in the ability of HVT and MDV to form an envelope was believed to account for the difference in their transmissibility in chickens. The results indicated that HVT replicated in the FFE and in the epidermis of the skin. However, attempts to localise the site(s) of MDV replication by electron microscopy were unsuccessful.  相似文献   

In ovo embryotoxicity of α-endosulfan adversely influences liver and brain metabolism and the immune system in chickens     

Pushpanjali  R.L. Prasad  S.K. Singh  S.B. Jadhao 《Pesticide biochemistry and physiology》2005,82(2):103-114

There is a lack of laboratory-based embryonic chicken toxicity studies with the ecologically relevant low dose/s of endosulfan that utilizes a more practical approach such as the chorioallontoic membrane (CAM) injection. In this investigation, 2μg AR grade α-endosulfan/egg (40% of LD₅₀ for embryos) was injected through the CAM in 12-day-old chicken embryos and the activities of glucose-6-phosphatase (G6Pase, EC 3.1.3.9), fructose 1,6-diphosphatase (FDPase, EC 3.1.3.11), adenosine triphosphatase (ATPase, EC 3.6.1.3) and succinic dehydrogenase (SDH, EC 1.3.99.1) and DNA and RNA content in liver and brain tissues and acetyl cholinesterase (AChE, EC 3.1.1.7) in the latter were determined at 24, 48, and 72 h post-exposure. The wet weight of the embryos did not differ between groups. Following endosulfan exposure, except increase in the hepatic ATPase activity (P < 0.01), there was a significant decrease in the following parameters: G6Pase activity in both the liver and brain (P < 0.01), SDH activity in the brain (P < 0.01), brain overall DNA and RNA concentration (P < 0.05), brain AChE activity (P < 0.01). Exposure of 18-day-old embryos to 2-μg endosulfan for 24 h caused decrease (P < 0.01) in the lymphocyte count and IgG content. Histopathology of thymus and bursa of Fabricius revealed a reduction in the population of thymic follicles, smaller thymocytes with the clear vacuoles in cytoplasm and fewer bursocytes accompanied by infiltration of erythrocytes in lymphoid follicles of the endosulfan-treated embryos. It was inferred that in ovo injection of 0.041 μg/g egg weight of α-endosulfan suppress gluconeogenesis (main energy source in embryonic life), nerve transmission, and immunity.  相似文献   

Genetic diversity analysis of two buffalo populations of northern India using microsatellite markers   总被引：3，自引：0，他引：3  

R. Arora  B. D. Lakhchaura  R. B. Prasad  M. S. Tantia  R. K. Vijh 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2004,121(2):111-118

The genetic diversity in two buffalo populations of northern India, the Bhadawari and the Tarai was assessed using a set of 22 heterologous (bovine) microsatellite markers. The average number of alleles across all loci in both populations was found to be 4.7, indicating that this set of 22 bovine microsatellite markers could be used to study genetic variation in buffalo species also. The overall polymorphic information content (PIC) value for these markers was 0.54. The average observed and expected heterozygosities for both populations were 0.59 and 0.64, respectively. Common alleles with varying allele frequencies in both populations also represented the genetic variability existing between Bhadawari and Tarai buffaloes. However the θ estimates for population differentiation indicated low levels of differentiation between the two populations. This was further supported by the low genetic distance (0.155) between Bhadawari and Tarai, which was calculated using Nei's standard genetic distance method. The present study on Bhadawari and Tarai populations represents a much‐needed preliminary effort that could be extended to other local buffalo populations of India as well.  相似文献   

Mitochondrial DNA analysis of Nepalese domestic dwarf cattle Lulu*     

Kumiko TAKEDA  Masahiro SATOH  Shreeram P. NEOPANE  Bahadur S. KUWAR  Hari D. JOSHI  Nanda P. SHRESTHA  Hiroshi FUJISE  Mariko TASAI  Takahiro TAGAMI  Hirofumi HANADA 《Animal Science Journal》2004,75(2):103-110

Dwarf Lulu cattle, the only Bos Taurus type of cattle in Nepal, are raised under severe environments in the mountainous zone of that country. In the present study, the body measurement traits, cytogenetic and molecular genetic characteristics of the Lulu cattle are investigated. Blood samples were collected from 31 animals in four villages (altitudes 2590–3550 m) in the southern part of Mustang. The Lulu cattle had a normal karyotype with 2n = 60, XY or XX. Only one male examined had a large submetacentric X‐chromosome and a small submetacentric taurine type Y‐chromosome. The mitochodrial DNA (mtDNA) genotypes were analyzed by PCR mediated restriction fragment length polymorphisms, displacement (D)‐loop region PCR mediated single strand conformation polymorphisms, and D‐loop region sequences. Many base substitutions were found in the D‐loop region, suggesting that the Lulu cattle originated from at least 10 maternal lines. Three types of mtDNA from these cattle were found, the Bos taurus type (n = 23), the Bos indicus type (n = 6), and the Bos grunniens type (n = 2). In the village at the lowest altitude, four of the five cows were of the Bos indicus type. These results indicated that mtDNA types of the Lulu cattle mostly belong to Bos taurus, but have been hybridized with Bos indicus cattle in lower‐elevation regions in their maternal lineage.  相似文献   

Radiographic,computed tomographic,and arthroscopic diagnosis of radioulnar incongruence in dogs with medial coronoid disease          下载免费PDF全文

Dominique J. Griffon DMV  MS  PhD  DECVS  DACVS  Ayman A. Mostafa BVSc  MVSc  PhD  Laurent Blond DMV  MSc  DACVR  David J. Schaeffer PhD 《Veterinary surgery : VS》2018,47(3):333-342

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Perceptions and opinions of pet owners in the United Sates about surgery,pain management,and anesthesia in dogs and cats          下载免费PDF全文

Bradley T. Simon DVM  MSc  DACVAA  Elizabeth M. Scallan DVM  MBA  MS  CVA  CCRP  Dirsko J. F. Von Pfeil DVM  DACVS  DECVS  DACVSMR  Daniel T. Boruta DVM  DACVAA  Rick Wall DVM  DACVSMR  CCRP  Belle M. Nibblett DVM  MVSc  DACVIM  O Odette DVM  DACVAA  Guy Beauchamp PhD  Paulo V. Steagall DVM  MSc  PhD  DACVAA 《Veterinary surgery : VS》2018,47(2):277-284

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