Screening for Small Molecule Inhibitors of BMP-Induced Osteoblastic Differentiation from Indonesian Marine Invertebrates     

Hiroyuki Yamazaki  Satoshi Ohte  Henki Rotinsulu  Defny S. Wewengkang  Deiske A. Sumilat  Delfly B. Abdjul  Wilmar Maarisit  Magie M. Kapojos  Michio Namikoshi  Takenobu Katagiri  Hiroshi Tomoda  Ryuji Uchida 《Marine drugs》2020,18(12)

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Spawning time and place of the Japanese eel Anguilla japonica in the North Equatorial Current of the western North Pacific Ocean     

Satoshi Ishikawa  Kunihiro Suzuki  Tadashi Inagaki  Shun Watanabe  Yobuo Kimura  Akihiro Okamura  Tsuguo Otake  Noritaka Mochioka  Yuzuru Suzuki  Hiroshi Hasumoto  Machiko Oya  Michael J Miller  Tae Won Lee  Hans Fricke  Katsumi Tsukamoto 《Fisheries Science》2001,67(6):1097-1103

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Manoalide derivatives from a marine sponge Luffariella sp. collected in Palau     

Michio  NAMIKOSHI  Shigeo  SUZUKI  Shiori  MEGURO  Hiroshi  NAGAI  Yoshio  KOIKE  Akira  KITAZAWA  Hisayoshi  KOBAYASHI  Taiko  ODA  Junko  YAMADA 《Fisheries Science》2004,70(1):152-158

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Improvement of dietary protein utilisation in chicks by medium chain triglyceride     

R. T. Mabayo  M. Furuse  K. Kita  J. Okumura 《British poultry science》1993,34(1):121-130

1. To improve the influence of variation of ME intake, an experiment was carried out using equalised feeding to investigate the comparative effects on protein and energy utilisation in chicks of diets containing medium chain triglyceride (MCT) and long chain triglyceride (LCT). Experimental diets were given at 3 different food intakes, namely, 100, 120 or 147 g/bird/10 d. The diets contained MCT or LCT on an isoenergetic basis. Maize oil and caprylic acid triglyceride respectively, were used as LCT and MCT sources.

2. Body weight gain and food efficiency of chicks significantly increased with the supplement of dietary MCT compared with dietary LCT at all food intakes. Protein retention and the efficiency of protein utilisation (protein retained/protein intake) at all food intakes also significantly increased with dietary MCT, while body fat and fat retention were significantly reduced. Chicks fed the LCT‐supple‐mented diet, on the other hand, had a lower protein retention, but significantly higher fat retention. The value for energy retention and the efficiency of energy utilisation (energy retained/ME intake) were not significantly different between MCT‐ and LCT‐supplemented diets.

3. It was concluded that supplementing MCT to the chick diet would improve body weight gain and protein utilisation while regulating fat deposition compared to the LCT supplemented diet, under equalised feeding conditions.  相似文献   

Feeding behaviour in chickens given diets containing medium chain triglyceride     

M. Furuse  R. T. Mabayo  Y. H. Choi  D. M. Denbow  J. Okumura 《British poultry science》1993,34(1):211-217

1. The effect of dietary medium chain triglyceride (MCT) on short‐term food intake was compared with the effect of long chain triglyceride (LCT) in chickens. Maize oil was used as the LCT while glyceryl tricaprylate (C 8) and glyceryl tricaprate (C 10) were used as MCT. Cumulative food intake was determined during the 6 h after the start of feeding.

2. Chicks were given diets containing 200 g C 8/kg diet, 200 g C 10/kg diet or 200 g LCT/kg diet in experiment 1. As early as 30 min after feeding, cumulative food intake in both MCT‐supplemented diets decreased significantly compared with the diet containing LCT.

3. To determine if endogenous cholecystokinin (CCK) was responsible for the decrease in food intake caused by MCT, birds were injected with the CCK‐A receptor antagonist devazepide (DVZ, 1 mg/kg BW) before diet presentation. DVZ had no effect on food intake with either LCT‐ or MCT‐supplemented diets.

4. In experiment 3, chicks were given a choice between either diets containing LCT and C 8, LCT and C 10, or C 8 and C 10 to confirm whether or not the palatability of the diets was influenced by the dietary fat sources. There was no difference in food intake between C 8 and C 10‐supplemented diets. However, chicks preferred the LCT‐supplemented diet compared with either of the diets containing MCT.  相似文献   

Protein synthesis measured in the whole body of chick embryos cultured in vitro     

K. Kita  S. Nakagawa  R. Pinontoan  J. Okumura  T. Muramatsu 《British poultry science》1993,34(5):1043-1047

1. Whole body protein synthesis was measured in chick embryos cultured in vitro. On day 7 of incubation chick embryos were cultured for 60 min in synthetic serum‐free medium containing 4‐[³H]phenylalanine. Specific radioactivities in free and protein‐bound phenylaline in the whole embryo were measured, starting 2 min after commencement of the culture process.

2. The values for fractional synthesis rate (FSR) estimated in vitro at 20, 30, 45 and 60 min during the embryo culture agreed well, ranging from 35 to 40%/d, suggesting that the method would serve as a useful model for studying the effect of growth promoters in chick embryos.

3. Bovine insulin in the synthetic medium did not affect FSR of protein in chick embryos cultured in vitro.  相似文献   

The rescue of Epstein--Barr virus from primary cultured cells of nasopharyngeal carcinoma.     

M Takada  M Murata  M Takei  S Nakagawa  H Okumura  A Kawamura 《Comparative immunology, microbiology and infectious diseases》1979,2(2-3):177-189

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Influence of ascorbic acid on the adverse effect of feeding a diet containing excess tyrosine to chicks     

M. Yanaka  J. Okumura 《British poultry science》1982,23(3):239-245

1. The effects of dietary or parenteral administration of ascorbic acid on the adverse effects of excess dietary tyrosine were investigated with young male White Leghorn chicks in a 2‐week experiment.

2. Addition of 10 g ascorbic acid/kg to the control diet (without excess tyrosine) produced no beneficial effects on performance. Excess dietary tyrosine caused depressions in all measures of performance.

3. Adding 0.1, 1, 10 or 20 g ascorbic acid/kg to the diet containing excess tyrosine tended to improve performance.

4. Subcutaneous injection of 50 mg ascorbic acid/bird d to chicks receiving excess tyrosine brought about a significant improvement in body‐weight gain.

5. The elevation of plasma free tyrosine caused by excess dietary tyrosine decreased as dietary ascorbic acid increased.

6. Ascorbic acid can alleviate, though not completely counteract, the adverse effect of excess dietary tyrosine.  相似文献   

Some factors affecting urinary and Faecal nitrogen loss by chickens fed on a protein‐free diet     

J. Okumura  Y. Isshikp  Y. Nakahiro 《British poultry science》1981,22(1):1-7

1. In adult colostomised cockerels, the rates of urinary and faecal nitrogen loss were measured when feeding low‐ and high‐energy, protein‐free diets after a preliminary period during which diets of differing energy and protein contents had been fed.

2. Urinary nitrogen excretion increased with increasing protein and decreasing energy in the preliminary diet.

3. Urinary nitrogen excretion was high during the first 3 d of feeding a high‐energy, protein‐free diet, decreased rapidly during the next 3 d and thereafter become relatively constant. However, in the case of a low‐energy, protein‐free diet, urinary nitrogen excretion gradually declined throughout the trial period of 15 d, resulting in increased urinary nitrogen excretion.

4. After a 3‐d period of adjustment faecal nitrogen loss from birds fed on a protein‐free diet was relatively constant under the conditions examined.  相似文献   

The nitrogen‐sparing effect of methionine in chicks receiving a protein‐free diet supplemented with arginine: Effect of various methionine substituents     

T. Muramatsu  J. Okumura 《British poultry science》1980,21(4):273-280

1. The nitrogen‐sparing effect of methionine in chicks fed on a protein‐free diet containing arginine was examined in three 10‐d trials. Chicks received either a protein‐free diet, this diet supplemented with arginine and methionine or diets containing arginine in which the methionine was replaced by various methionine‐related compounds.

2. Body‐weight changes, nitrogen retentions and uric acid‐nitrogen excretion indicated that the methyl moiety was unlikely to contribute to nitrogen sparing activity and that cysteine, or possibly glutathione, played an important role. The possible mechanism of the nitrogen‐sparing effect is discussed.  相似文献