Clinical utility of an immunoglobulin A-based serological panel for the diagnosis of chronic enteropathy in dogs     

Daniel K. Langlois  Jessica C. Pritchard  M. Katherine Tolbert  Albert E. Jergens  Gary Block  Andrew S. Hanzlicek  Jared A. Jaffey  Jörg M. Steiner  Sina Marsilio  Sara A. Jablonski 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2023,37(2):446-454

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Evaluation of serum 25-hydroxyvitamin D,C-reactive protein,and haptoglobin as biomarkers in dogs newly diagnosed with histoplasmosis     

Betsy Hernandez  Jared A. Jaffey  Leah A. Cohn  Robert C. Backus  Kate KuKanich  Andrew S. Hanzlicek  Valerie J. Parker  Mary E. White  Randy Ringold  Emily Westerback  Leah Freilich  Charlotte Bolch 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2023,37(2):476-483

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Effects of intra-articular injection of an acellular equine liquid amniotic allograft in healthy equine joints     

Danica D. Wolkowski DVM  Robert D. McCarthy DVM  Mike J. Schoonover DVM  MS  DACVS-LA  DACVSMR  Jared D. Taylor DVM  MPH  PhD  DACVIM  DACVPM  Timothy G. Eastman DVM  MS  DACVS 《Veterinary surgery : VS》2023,52(1):62-68

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Convenient large-scale purification of yessotoxin from Protoceratium reticulatum culture and isolation of a novel furanoyessotoxin     

Loader JI  Hawkes AD  Beuzenberg V  Jensen DJ  Cooney JM  Wilkins AL  Fitzgerald JM  Briggs LR  Miles CO 《Journal of agricultural and food chemistry》2007,55(26):11093-11100

Yessotoxins from a large-scale culture (226 L) of Protoceratium reticulatum strain CAWD129 were harvested by filtration followed by solid-phase extraction. The extract was purified by column chromatography over basic alumina and reverse-phase flash chromatography to afford pure yessotoxin (193 mg). Isolation of yessotoxin was greatly facilitated by selection of a strain which did not produce analogues that interfered with yessotoxin isolation. In addition to yessotoxin, numerous minor yessotoxins were detected by LC-MS in other fractions. From one of these, an early eluting minor analogue with the same molecular weight as yessotoxin and a similar mass spectrometric fragmentation pattern was isolated. This analogue was identified by NMR and mass spectrometry as a novel yessotoxin analogue containing a furan ring in the side chain. This finding reveals biosynthetic flexibility of the yessotoxin pathway in P. reticulatum and confirms earlier findings of production of many minor yessotoxin analogues by this alga. Production of these analogues appeared to be a constitutive trait of P. reticulatum CAWD129.  相似文献   

Infection with foot-and-mouth disease virus (FMDV) induces a natural killer (NK) cell response in cattle that is lacking following vaccination     

Jared R. Patch  Pervaiz A. Dar  Ryan Waters  Felix N. Toka  Jose Barrera  Christopher Schutta  Ganesh Kondabattula  William T. Golde 《Comparative immunology, microbiology and infectious diseases》2014

Natural killer (NK) cells play a role in innate antiviral immunity by directly lysing virus-infected cells and producing antiviral cytokines such as interferon gamma (IFN-γ). We developed a system for characterizing the bovine NK response to foot-and-mouth disease virus (FMDV), which causes a disease of cloven-hoofed animals and remains a threat to livestock industries throughout the world. IL-2 stimulation of PBMC resulted in poor killing of human K562 cells, which are often used as NK target cells, while lysis of the bovine BL3.1 cell line was readily detected. Depletion of NKp46-expressing cells revealed that 80% of the killing induced by IL-2 could be attributed to NKp46⁺ cells. In order to characterize the response of NK cells against FMDV in vivo, we infected groups of cattle with three different strains of the virus (A24 Cruzeiro, O1 Manisa, O Hong Kong) and evaluated the cytolytic ability of NK cells through the course of infection. We consistently observed a transient increase in cytolysis, although there was variation in magnitude and kinetics. This increase in cytolysis remained when CD3⁺ cells were removed from the preparation of lymphocytes, indicating that cytolysis was independent of MHC-T cell receptor interaction or γδ T cell activation. In contrast, animals monitored following vaccination against FMDV did not exhibit any increase in NK killing. These data suggest that NK cells play a role in the host immune response of cattle against FMDV, and contrast with the suppression of NK activity previously observed in swine infected with FMDV.  相似文献   

Photoperiod and temperature affects seasonal ovarian gene expression of p450 aromatase and gonadotropin receptors in Atlantic Salmon (Salmo salar L.) broodstock     

Eva Andersson  Sampath R. Kumar  Jared Ackers  Geir Lasse Taranger  Sigurd Olav Stefansson  John M. Trant 《Fish physiology and biochemistry》2003,28(1-4):411-411

Photoperiod and temperature modulated the seasonal pattern of ovarian gene expression of P450 aromatase, Follicle-Stimulating Hormone receptor and Luteinizing Hormone receptor in Atlantic salmon broodstock.  相似文献   

Farmers and their languages: the first expansions   总被引：1，自引：0，他引：1  

Diamond J  Bellwood P 《Science (New York, N.Y.)》2003,300(5619):597-603

The largest movements and replacements of human populations since the end of the Ice Ages resulted from the geographically uneven rise of food production around the world. The first farming societies thereby gained great advantages over hunter-gatherer societies. But most of those resulting shifts of populations and languages are complex, controversial, or both. We discuss the main complications and specific examples involving 15 language families. Further progress will depend on interdisciplinary research that combines archaeology, crop and livestock studies, physical anthropology, genetics, and linguistics.  相似文献   

Energetics of hydrogen bond network rearrangements in liquid water     

Smith JD  Cappa CD  Wilson KR  Messer BM  Cohen RC  Saykally RJ 《Science (New York, N.Y.)》2004,306(5697):851-853

A strong temperature dependence of oxygen K-edge x-ray absorption fine structure features was observed for supercooled and normal liquid water droplets prepared from the breakup of a liquid microjet. Analysis of the data over the temperature range 251 to 288 kelvin (-22 degrees to +15 degrees C) yields a value of 1.5 +/- 0.5 kilocalories per mole for the average thermal energy required to effect an observable rearrangement between the fully coordinated ("ice-like") and distorted ("broken-donor") local hydrogen-bonding configurations responsible for the pre-edge and post-edge features, respectively. This energy equals the latent heat of melting of ice with hexagonal symmetry (ice Ih) and is consistent with the distribution of hydrogen bond strengths obtained for the "overstructured" ST2 model of water.  相似文献   

Estrogen induces lipophosphoprotein in serum of male Xenopus laevis   总被引：2，自引：0，他引：2  

R A Wallace  D W Jared 《Science (New York, N.Y.)》1968,160(823):91-92

Administration of estradiol 17beta to male Xenopus laevis induces the appearance in serum of large amounts of a serum lipophosphoprotein which is not readily removed from the circulation and which can be resolved from other serum components by chromatography on triethylaminoethyl-cellulose. The initial rate of production of serum lipophosphoprotein is independent of the amount of estrogen administered, but the maximum rate of production and the time taken to attain this rate are dose-dependent.  相似文献   

Policy forum offered new ideas     

Liu J  Diamond J 《Science (New York, N.Y.)》2008,321(5889):639

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