Drug Residues after Intravenous Anesthesia and Intrathecal Lidocaine Hydrochloride Euthanasia in Horses     

M. Aleman  E. Davis  H. Knych  A. Guedes  F. Smith  J.E. Madigan 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2016,30(4):1322-1326

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Equine herpesvirus-4 kinetics in peripheral blood leukocytes and nasopharyngeal secretions in foals using quantitative real-time TaqMan PCR.     

Nicola Pusterla  Christian M Leutenegger  W David Wilson  Johanna L Watson  Gregory L Ferraro  John E Madigan 《Journal of veterinary diagnostic investigation》2005,17(6):578-581

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Characterization of Clostridium difficile isolates from foals with diarrhea: 28 cases (1993-1997)     

Magdesian KG  Hirsh DC  Jang SS  Hansen LM  Madigan JE 《Journal of the American Veterinary Medical Association》2002,220(1):67-73

OBJECTIVE: To determine molecular characteristics of Clostridium difficile isolates from foals with diarrhea and identify clinical abnormalities in affected foals. DESIGN: Retrospective study. ANIMALS: 28 foals with C difficile-associated diarrhea. PROCEDURE: Toxigenicity, molecular fingerprinting, and antibiotic susceptibility patterns were determined. Information on signalment, clinical findings, results of clinicopathologic testing, whether antimicrobials had been administered prior to development of diarrhea, and outcome was obtained from the medical records. RESULTS: Twenty-three (82%) foals survived. Toxin A and B gene sequences were detected in isolates from 24 of 27 foals, whereas the toxin B gene alone was detected in the isolate from 1 foal. Results of an ELISA for toxin A were positive for fecal samples from only 8 of 20 (40%) foals. Ten of 23 (43%) isolates were resistant to metronidazole. Molecular fingerprinting revealed marked heterogeneity among isolates, except for the metronidazole-resistant isolates. Sixteen foals had tachypnea. Hematologic abnormalities were indicative of inflammation. Common serum biochemical abnormalities included metabolic acidosis, hyponatremia, hypocalcemia, azotemia, hypoproteinemia, hyperglycemia, and high enzyme activities. Passive transfer of maternal antibodies was adequate in all 12 foals evaluated. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that a large percentage of C difficile isolates from foals with diarrhea will have the toxin A and B gene sequences. Because of the possibility that isolates will be resistant to metronidazole, susceptibility testing is warranted. Clostridium difficile isolates from foals may have a substantial amount of molecular heterogeneity. Clinical and hematologic findings in affected foals are similar to those for foals with diarrhea caused by other pathogens.  相似文献   

One-tube PCR for the detection of the Ehrlichia phagocytophila genogroup     

Pusterla N  Chae JS  DeRock E  Madigan JE 《The Veterinary record》2000,147(1):22-23

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Sensory Evoked Potentials of the Trigeminal Nerve for the Diagnosis of Idiopathic Headshaking in a Horse     

M. Aleman  D. Rhodes  D.C. Williams  A. Guedes  J.E. Madigan 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2014,28(1):250-253

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Electrophysiological studies in American Quarter horses with neuroaxonal dystrophy     

Finno CJ  Aleman M  Ofri R  Hollingsworth SR  Madigan JE  Winfield L  Bannasch DL 《Veterinary ophthalmology》2012,15(Z2):3-7

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Sensory Nerve Conduction and Somatosensory Evoked Potentials of the Trigeminal Nerve in Horses with Idiopathic Headshaking     

M. Aleman  D.C. Williams  R.J. Brosnan  J.E. Nieto  K.J. Pickles  J. Berger  R.A. LeCouteur  J.E. Madigan 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2013,27(6):1571-1580

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Detection of EHV-1 neuropathogenic strains using real-time PCR in the neural tissue of horses with myeloencephalopathy   总被引：2，自引：0，他引：2  

Leutenegger CM  Madigan JE  Mapes S  Thao M  Estrada M  Pusterla N 《The Veterinary record》2008,162(21):688-690

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Intravenous infusion of magnesium sulfate and its effect on horses with trigeminal‐mediated headshaking     

Shara A. Sheldon  Monica Aleman  Lais Rosa R. Costa  Ana C. Santoyo  Quinn Howey  John E. Madigan 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2019,33(2):923-932

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Parenteral nutrition in neonatal foals: clinical description, complications and outcome in 53 foals (1995-2005)     

Myers CJ  Magdesian KG  Kass PH  Madigan JE  Rhodes DM  Marks SL 《Veterinary journal (London, England : 1997)》2009,181(2):137-144

This retrospective study describes the use of and complications associated with parenteral nutrition (PN) administration to 53 equine neonates at the University of California Veterinary Medical Teaching Hospital. Medical records were examined and information obtained on signalment, physical examination, clinical diagnosis, outcome, total hospitalization time, insulin administration, microbiology culture results, other complications (i.e. thrombophlebitis) and necropsy findings. Complete blood count and serum biochemistry analytes, venous blood gas, serum electrolyte and glucose concentrations, and blood lactate concentration results were compared before and during PN administration in all foals. Seventeen foals (32%) developed hypertriglyceridemia (>200mg/dL). Triglyceride concentrations >200mg/dL were significantly (P=0.049) associated with non-survival. Forty-seven foals (89%) developed hyperglycemia (blood glucose >120mg/dL) and eight (15%) developed catheter-related complications (thrombosis or local sepsis). Packed cell volume, total protein, creatinine, blood urea nitrogen, and sorbitol dehydrogenase concentrations decreased while foals were on PN, while serum chloride concentration increased. This study highlighted that hypertriglyceridemia during the acute phase of neonatal illness may be detrimental to outcome, and that the safety of lipid-containing solutions in foals warrants further study.  相似文献