Validating an empiric sulfadiazine–trimethoprim dosage regimen for treatment of Escherichia coli and Staphylococcus delphini infections in mink (Neovison vison)     

Amir Atabak Ronaghinia  Nanett Kvist Nikolaisen  Stine Green Hansen  Helle Harding Poulsen  Henrik Lauritz Frandsen  Tina Struve  Pierre‐Louis Toutain  Peter Damborg 《Journal of veterinary pharmacology and therapeutics》2021,44(1):93-106

Antimicrobial agents are used extensively off‐label in mink, as almost no agents are registered for this animal species. Pharmacokinetic (PK) and pharmacodynamic (PD) data are required to determine antimicrobial dosages specifically targeting mink bacterial pathogens. The aims of this study were to assess, in a PKPD framework, the empirical dosage regimen for a combination of trimethoprim (TMP) and sulfadiazine (SDZ) in mink, and secondarily to produce data for future setting of clinical breakpoints. TMP and SDZ PK parameters were obtained experimentally in 22 minks following IV or oral administration of TMP/SDZ (30 mg/kg, i.e. 5 mg/kg TMP and 25 mg/kg SDZ). fAUC/MIC with a target value of 24 hr was selected as the PKPD index predictive of TMP/SDZ efficacy. Using a modeling approach, PKPD cutoffs for TMP and SDZ were determined as 0.062 and 16 mg/L, respectively. By incorporating an anticipated potentiation effect of SDZ on TMP against Escherichia coli and Staphylococcus delphini, the PKPD cutoff of TMP was revised to 0.312 mg/L, which is above the tentative epidemiological cutoffs (TECOFF) for these species. The current empirical TMP/SDZ dosage regimen (30 mg/kg, PO, once daily) therefore appears adequate for treatment of wild‐type E. coli and S. delphini infections in mink.  相似文献   

Implantable loop recorders can detect paroxysmal atrial fibrillation in Standardbred racehorses with intermittent poor performance     

Rikke Buhl  Sarah D. Nissen  Marie L. K. Winther  Sofie K. Poulsen  Charlotte Hopster-Iversen  Thomas Jespersen  Prashanthan Sanders  Helena Carstensen  Eva M. Hesselkilde 《Equine veterinary journal》2021,53(5):955-963

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Diagnosis and treatment of a selective immunoglobulin M glomerulonephropathy in a quarter horse gelding     

Mcsloy A  Poulsen K  Fisher PJ  Armien A  Chilton JA  Peek S 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2007,21(4):874-877

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In situ measurement of grain rotation during deformation of polycrystals     

Margulies L  Winther G  Poulsen HF 《Science (New York, N.Y.)》2001,291(5512):2392-2394

Texture evolution governs many of the physical, chemical, and mechanical properties of polycrystalline materials, but texture models have only been tested on the macroscopic level, which makes it hard to distinguish between approaches that are conceptually very different. Here, we present a universal method for providing data on the underlying structural dynamics at the grain and subgrain level. The method is based on diffraction with focused hard x-rays. First results relate to the tensile deformation of pure aluminum. Experimental grain rotations are inconsistent with the classical Taylor and Sachs models.  相似文献   

Sex Determination of Bovine Embryo Biopsies Using in situ Hybridization*     

P.D. Thomsen  M. Schwerin  P.H. Poulsen  B. Avery 《Reproduction in domestic animals》1991,26(2):66-69

A male specific bovine DNA fragment was used as probe to determine the sex of bovine interphase cells by in situ hybridization. This method also proved useful for determining the sex of bovine embryos.  相似文献   

Abomasal emptying rate in goats and cows measured by external counting of radioactive sodium chromate injected directly into the abomasum     

B E Jones  J S Poulsen 《Nordisk veterinaermedicin》1974,26(1):13-21

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Roentgenologic and macroscopically prepared findings in lumbar vertebrae of the New Zealand White rabbit (Oryctolagus cuniculus f. domestica) during postnatal development     

C Poulsen Nautrup 《DTW. Deutsche tier?rztliche Wochenschrift》1986,93(6):254-260

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Sectional notes     

H. W. Poulsen  H. G. Zuckerman  C. H. Metzger  W. B. Ward  W. C. Edmundson  E. R. Bennet  R. A. Jehle  A. B. Beaumont  John S. Gardner  E. L. Newdick  Frank W. Hussey  E. J. Wheeler  H. C. Moore  Marx Koehnke  A. G. Tolaas  E. E. Isaac  H. O. Werner  O. Butler  William H. Martin  K. H. Fernow  E. R. Jackman  E. B. Tussing  E. V. Hardenburg  J. B. R. Dickey  K. H. Klages  G. S. Ralston  H. L. Bailey  John Tucker 《American Journal of Potato Research》1934,11(8):207-226

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Role of phospholipase A2 in the induction of drip loss in porcine muscle     

Poulsen KA  Young JF  Theil P  Kolko M  Oksbjerg N  Lambert IH 《Journal of agricultural and food chemistry》2007,55(5):1970-1976

The role of phospholipase A2 in the induction of drip loss from pig muscle has been investigated. In samples from porcine M. longissimus dorsi, total PLA2 activity as well as mRNA and protein levels of the group VIA iPLA2 (iPLA2-VIA) increased during the initial 4 h post-mortem period. Morphological studies of porcine muscle showed that at 4 h post-mortem, gaps had formed between muscle fibers and that the sarcolemma membrane borders appeared blurred. At the same time iPLA2-VIA protein levels were increased inside muscle fibers and at the sarcolemma. iPLA2-VIA mRNA abundance in samples from different breeds of pigs with variations in drip loss revealed no clear correlation between drip loss level and iPLA2-VIA expression. Together, these data indicate that during the post-mortem period, iPLA2-VIA expression and activity is increased at the muscle fiber membranes. PLA2 activity may affect membrane permeability and consequently the progression of drip formation in porcine muscle.  相似文献   

An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy     

During MJ  Symes CW  Lawlor PA  Lin J  Dunning J  Fitzsimons HL  Poulsen D  Leone P  Xu R  Dicker BL  Lipski J  Young D 《Science (New York, N.Y.)》2000,287(5457):1453-1460

The brain is generally considered immunoprivileged, although increasing examples of immunological responses to brain antigens, neuronal expression of major histocompatibility class I genes, and neurological autoimmunity have been recognized. An adeno-associated virus (AAV) vaccine generated autoantibodies that targeted a specific brain protein, the NR1 subunit of the N-methyl-D-aspartate (NMDA) receptor. After peroral administration of the AAV vaccine, transgene expression persisted for at least 5 months and was associated with a robust humoral response in the absence of a significant cell-mediated response. This single-dose vaccine was associated with strong anti-epileptic and neuroprotective activity in rats for both a kainate-induced seizure model and also a middle cerebral artery occlusion stroke model at 1 to 5 months following vaccination. Thus, a vaccination strategy targeting brain proteins is feasible and may have therapeutic potential for neurological disorders.  相似文献