A framework for evaluation of on-farm mastitis diagnostics in Australia     

RN Zadoks  E Scholz  SM Rowe  JM Norris  HB Pooley  J House 《Australian veterinary journal》2023,101(4):142-152

Numerous culture-based diagnostics are available on the Australian and international markets for on-farm detection of bacterial pathogens in milk. Use of such diagnostics may provide an opportunity to improve the prudent use of antimicrobials in udder health management. Farms are low-resource settings in terms of diagnostic microbiology capacity. The World Health Organisation has identified criteria for the evaluation of diagnostic tests in low resource settings based on Accuracy, Sensitivity, Specificity, User-friendliness, being Rapid or Robust, Equipment-free and being Deliverable (ASSURED). Here, we review how those criteria can be interpreted in the context of microbiological diagnosis of mastitis pathogens, and how on-farm diagnostics that are currently available in Australia perform relative to ASSURED criteria. This evaluation identifies multiple trade-offs, both with regard to scientific criteria and with regards to convenience criteria. More importantly, the purpose of testing may differ between farms, and test performance should be evaluated relative to its intended use. The ability of on-farm mastitis diagnostics to inform mastitis treatment decision-making in a timely and cost-effective manner depends not just on test characteristics but also on farm-specific pathogen prevalence, and on the farm enterprise's priorities and the farm manager's potential courses of action. With most assay evaluations to date conducted in professional laboratories, there is a surprising dearth of information on how well any of the diagnostic tests perform on-farm and, indeed, of the on-farm decision-making processes that they aim to inform.  相似文献   

Effects of polyethylene roughage substitute on the rumen of fattening steers.          下载免费PDF全文

H J Greene  B Schiefer  R E Moffatt    H H Nicholson 《The Canadian veterinary journal. La revue veterinaire canadienne》1974,15(7):191-197

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Mercury and mink. I. The use of mercury contaminated fish as a food for ranch mink.          下载免费PDF全文

G Wobeser  N O Nielsen    Schiefer 《Canadian journal of veterinary research》1976,40(1):30-33

Adult female and juvenile ranch mink were fed rations containing 50 and 75% of fish containing 0.44 ppm total mercury over a 145 day period. There was no clinical or pathological evidence of intoxication in these animals and mercury concentrations in tissue appeared to be at a level below that associated with toxicity.  相似文献   

Behavior of prototheca species in mammalian tissue     

B Schiefer  B Gedek 《Berliner und Münchener tier?rztliche Wochenschrift》1968,81(24):485-490

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Bovine abortion associated with Cytomegalovirus infection   总被引：1，自引：0，他引：1  

B Schiefer 《Zentralblatt für Veterin?rmedizin. Reihe B. Journal of veterinary medicine. Series B》1974,21(3):145-151

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GUIDE TO THE CARE AND USE OF EXPERIMENTAL ANIMALS, VOLUME 2          下载免费PDF全文

H.B. Schiefer 《Canadian journal of veterinary research》1985,49(1):49

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Subacute toxicity of dietary 3-acetyldeoxynivalenol in mice.   总被引：1，自引：1，他引：0       下载免费PDF全文

O B Kasali  H B Schiefer  D S Hancock  B R Blakley  R S Tomar    R Greenhalgh 《Canadian journal of veterinary research》1985,49(3):319-322

3-Acetyldeoxynivalenol was incorporated into a semisynthetic diet at levels of 2.5, 5, 10 or 20 ppm and fed to mice for up to 48 days. Body weights and feed consumption were determined, and blood samples for hematological evaluation were taken. Selected tissues were examined microscopically and the humoral immune response was assessed using the Jerne plaque assay. 3-Acetyldeoxynivalenol caused a dose-related depressed feed consumption within the first seven days and reduced body weight until day 14 when fed at levels up to 10 ppm. When fed at a level of 20 ppm, an initial depression in body weight gain and a general malaise were followed by a return to normal. At necropsy, no macroscopic or microscopic lesions could be found. The immune response was not significantly affected after seven or 14 days, but at 21 days, a dose-dependent enhanced response was observed. The findings indicate that, after an initial period of reduced feed intake, animals are apparently able to overcome the toxic effects of 3-acetyldeoxynivalenol.  相似文献   

Möglichkeiten einer Differenzierung von Lungenwurminfektionen des Schafes im histologischen Schnittpräparat     

H. Sedlmeier  B. Schiefer  E. Menschel 《Zoonoses and public health》1969,16(2):143-157

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Granulomatous Dermatitis in Carnivores Associated with Dermatophyte Infection          下载免费PDF全文

N. W. Holfeld  B. Schiefer    B. R. Boycott 《The Canadian veterinary journal. La revue veterinaire canadienne》1980,21(4):103-105

Nine cases of granulomatous dermatitis in carnivores (eight dogs, one cat) are described. In three cases, in which there were no fungi in hair shafts, nor any other evidence of mycotic infection initially, fungal elements were demonstrated in the granulomas with the aid of special stains (PAS and Grocott). Granulomatous dermatitis in case of dermatophyte infections is thought to be an hypersensitivity reaction and has been reported to occur in a variety of mammals. It is suggested that pyogranulomatous skin reactions and trichogranulomas could be associated with dermatophytes and it is recommended to carry out further laboratory studies in order to detect fungi in such cases.  相似文献   

The pathology of bovine abortion due to Corynebacterium pyogenes.          下载免费PDF全文

B Schiefer  J F Pantekoek    R E Moffatt 《The Canadian veterinary journal. La revue veterinaire canadienne》1974,15(11):322-326

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