Rice: Nilaparvata lugens Stal interaction—current status and future prospects of brown planthopper management     

Jeevanandham  Niranjanadevi  Raman  Renuka  Ramaiah  Duraisingh  Senthilvel  Velprabakaran  Mookaiah  Shanthi  Jegadeesan  Ramalingam 《植物病害和植物保护杂志》2023,130(1):125-141

Journal of Plant Diseases and Protection - Pragmatically, Oryza sativa L. is the most considerable food in the world and about 3 billion people rely on rice for their living sustenance and...  相似文献   

A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis     

Farrell A  Thirugnanam S  Lorestani A  Dvorin JD  Eidell KP  Ferguson DJ  Anderson-White BR  Duraisingh MT  Marth GT  Gubbels MJ 《Science (New York, N.Y.)》2012,335(6065):218-221

Exocytosis is essential to the lytic cycle of apicomplexan parasites and required for the pathogenesis of toxoplasmosis and malaria. DOC2 proteins recruit the membrane fusion machinery required for exocytosis in a Ca(2+)-dependent fashion. Here, the phenotype of a Toxoplasma gondii conditional mutant impaired in host cell invasion and egress was pinpointed to a defect in secretion of the micronemes, an apicomplexan-specific organelle that contains adhesion proteins. Whole-genome sequencing identified the etiological point mutation in TgDOC2.1. A conditional allele of the orthologous gene engineered into Plasmodium falciparum was also defective in microneme secretion. However, the major effect was on invasion, suggesting that microneme secretion is dispensable for Plasmodium egress.  相似文献   

Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes     

Stubbs J  Simpson KM  Triglia T  Plouffe D  Tonkin CJ  Duraisingh MT  Maier AG  Winzeler EA  Cowman AF 《Science (New York, N.Y.)》2005,309(5739):1384-1387

The malaria parasite, Plasmodium falciparum, exploits multiple ligand-receptor interactions, called invasion pathways, to invade the host erythrocyte. Strains of P. falciparum vary in their dependency on sialated red cell receptors for invasion. We show that switching from sialic acid-dependent to -independent invasion is reversible and depends on parasite ligand use. Expression of P. falciparum reticulocyte-binding like homolog 4 (PfRh4) correlates with sialic acid-independent invasion, and PfRh4 is essential for switching invasion pathways. Differential activation of PfRh4 represents a previously unknown mechanism to switch invasion pathways and provides P. falciparum with exquisite adaptability in the face of erythrocyte receptor polymorphisms and host immune responses.  相似文献