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DV Wilson BVSc MS Dipl ACVA GV Bohart DVM AT Evans DVM MS Dipl ACVA S Robertson BVMS PhD Dipl ACVA Dipl ECVA Y Rondenay†DVM 《Veterinary anaesthesia and analgesia》2002,29(1):54-57
Objective To assess the effectiveness of a detomidine infusion technique to provide standing chemical restraint in the horse. Design Retrospective study. Animals Fifty‐one adult horses aged 9.5 ± 6.9 years (range 1–23 years) and weighing 575 ± 290.3 kg. Methods Records of horses presented to our clinic over a 3‐year period in which a detomidine infusion was used to provide standing chemical restraint were reviewed. Information relating to the types of procedure performed, duration of infusion, drug dosages and adjunct drugs administered was retrieved. Results Detomidine was administered as an initial bolus loading dose (mean ± SD) of 7.5 ± 1.87 µg kg?1. The initial infusion rate was 0.6 µg kg?1 minute?1, and this was halved every 15 minutes. The duration of the infusion ranged from 20 to 135 minutes. Twenty horses received additional detomidine or butorphanol during the procedure. All horses undergoing surgery received local anesthesia or epidural analgesia in addition to the detomidine infusion. A wide variety of procedures were performed in these horses. Conclusions Detomidine administered by infusion provides prolonged periods of chemical restraint in standing horses. Supplemental sedatives or analgesics may be needed in horses undergoing surgery. Clinical relevance An effective method that provides prolonged periods of chemical restraint in standing horses is described. The infusion alone did not provide sufficient analgesia for surgery and a significant proportion of animals required supplemental sedatives and analgesics. 相似文献
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G.V Quinnan F.A Ennis 《Comparative immunology, microbiology and infectious diseases》1980,3(3):283-290
Cell-mediated immunity is of critical significance in the host response to cytomegalovirus infection. This fact is evidenced by numerous reports of disease in immunosuppressed hosts and by other clinical and experimental observations. Methodologies are now available for elucidation of the specific role of the various facets of cell-mediated immunity in normal and susceptible individuals during different stages of infection. Most progress has been made recently using assays of lymphocyte transformation and cell-mediated immune lysis, but other areas also deserve specific attention. A comprehensive picture of the function of cellular immunity should greatly advance understanding of disease pathogenesis as well as direct the development of future models for immunotherapy. 相似文献
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When Bill Manktelow died at his home in his 74th year on the 3rd of May, the veterinary profession lost a major figure whose work over 50 years has influenced many people in all branches of the profession. 相似文献
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