THE EFFECT OF A COMBINATION OF MEDETOMIDINE-BUTORPHANOL AND MEDETOMIDINE, BUTORPHANOL, ATROPINE ON GLOMERULAR FILTRATION RATE IN DOGS     

Jennifer B.  Grimm  DVM  MS  Kurt A.  Grimm  DVM  MS  Stephen K.  Kneller  DVM  MS  William J.  Tranquilli  DVM  MS  Sonia S.  Crochik  DVM  MS  Matthew G.  Bischoff  DVM  Jennifer L.  Podolski  DVM 《Veterinary radiology & ultrasound》2001,42(5):458-462

The effects of intramuscularly administered medetomidine and butorphanol (MB), and medetomidine, butorphanol, atropine (MBA) on glomerular filtration rate (GFR) were determined in six dogs as measured by 99m-Tc-labeled diethylenetriaminepentaacetic acid (99mTc-DTPA) nuclear scintigraphy. Direct systolic, diastolic, and mean arterial blood pressures and heart rate were measured at regular time intervals before, during, and after GFR calculations. The mean GFR measurement following MB was significantly greater (4.44 ml/min/kg) than following MBA (3.82 ml/min/kg) or saline treatment (3.41 ml/min/kg). There was no significant difference between the mean GFR measurements following MBA injection and following saline injection. Diastolic and mean arterial pressures following MBA injection were significantly higher than the values recorded after either MB or saline alone. Heart rate following MB administration was significantly lower than that recorded for dogs receiving MBA or saline alone. The results of this study indicate that the administration of medetomidine in combination with butorphanol significantly increases total GFR in healthy dogs, while the administration of the combination of medetomidine, butorphanol, and atropine does not.  相似文献   

COLLAGENASE CHEMONUCLEOLYSIS—A LONG TERM RADIOGRAPHIC STUDY IN NORMAL DOGS     

Matthew A.O.  Atilola  DVM  PhD  Joanne R.  Cockshutt  DVM  MS  Ron  Mclaughlin  DVM  DVSc  Susan M.  Cochrane  DVM  DVSc  Paul W.  Pennock  DVM  MS 《Veterinary radiology & ultrasound》1993,34(5):321-324

Five clinically normal five year old dogs were used in this study. From a randomised table inter ver tebral discs were each injected with either collagenase or calcium chloride diluent. The surgically exposed cervical discs were injected with 50 units whereas thoracic and lumbar discs were injected under fluoroscopic guidance with 100 units of the enzyme. Postinjection radiographs revealed significant (p ≤ .05) disc space narrowing in enzyme injected discs. The cervical discs had the highest frequency of radiographic narrowing (87%) followed by the thoracic (70%) and lumbar (53%) discs. Spondylosis deformans developed at the sites of cervical enzyme injections. None of the dogs had neurologic abnormalities one year postinjection.  相似文献   

The Effect of Diet on the Biochemical Composition of Juvenile Artemia: Potential Formulations for Rock Lobster Aquaculture     

Matthew M.  Nelson Ben D.  Mooney Peter D.  Nichols Charles E  Phleger Greg G.  Smith Piers  Hart Arthur J.  Ritar 《Journal of the World Aquaculture Society》2002,33(2):146-157

The lipid class and fatty acid (FA) composition of juvenile Artemia fed continuously on four diets—the microalga Tetraselmis suecica , a mix of oat bran-wheat germ-lecithin (OWL), OwL-eicosapentaenoic acid (EPA), and OWL-EPA-arachidonic acid (AA)—were examined over a 9-d experiment in an attempt to approximate the FA profile of phyllosoma larvae of wild southern rock lobster Jasus edwardrii . The main difference in lipid class composition of Artemia fed the four diets was the relative level of polar lipid (PL) and triacylglycerol (TAG). By day 9, the algal-fed Artemia were highest in PL (95% of total lipid) and lowest in TAG (2%), whereas the remaining diets resulted in Artemia with 16–30% PL and 41–82% TAG. After 2 d, the relative FA composition of all Artemia treatments closely reflected those of the diets, with no marked change after further feeding (to day 9). In terms of the content of essential polyunsaturated fatty acids (PUFA), by day 5 Artemia fed: 1) with the algal diet contained 7 mg/g FA dry mass (0.3% DHA, 6.3% EPA, 3.4% AA of total FA); 2) with the OWL diet contained 3 mg/g (0.3% DHA, 0.9% EPA, 0.7% AA); 3) with the OWL-EPA diet contained 55 mg/g (6.2% DHA, 11.6% EPA, 1.1% AA); and 4) with the OWL-EPA-AA contained 83 mg/g (3.8% DHA, 7.5% EPA, 17.4% AA). The PUFA profiles of Artemia using the OWL-oil diets were similar to wild rock lobster phyllmmata, although levels of doco-sahexaenoic acid (DHA) were lower (10% DHA) than in J. edwardsii larvae. On the basis of PUFA composition data alone, the results suggest the suitability of the OWL-oil mixed diets for consideration for feeding to Artemia used in the culture of southern rock lobster larvae, particularly if the level of DHA can be further enhanced.  相似文献   

现代母猪管理的挑战     

王永康  Betsy Newton 《国外畜牧学(猪与禽)》2001,(6):27-30

现代母猪的基因型不同于传统母猪的基因型 ,这是毫无疑问的。近年来所见母猪生产率的提高 ,并不仅仅归因于遗传改进 ,而是还与设施、健康状况和管理方法的改进有关。然而 ,现代母猪已被特别培育成具有更高产、更高泌乳量、更强的母性和更高的胴体瘦肉率 (见表 1 )。　表 1　现代母猪和传统母猪基因型的特点性状现代母猪传统母猪基因型差异 ( % )窝产仔数　总数 11 6 10 0 +16　活产数 10 89 0 +2 0断奶仔数　窝断奶数 9 97 5 +32年断奶数 2 2 0 15 0 +47断奶窝重 (千克 )　校正至 2 1日龄断奶重 6 3 5 4 0 8+5 5母猪躯体成分　成年体重…  相似文献   

Effect of feed intake during late development on pubertal onset and resulting body composition in crossbred gilts.     

E A Newton  D C Mahan 《Journal of animal science》1992,70(12):3774-3780

A total of 105 nonboar-exposed, F2 ([Landrace x Yorkshire] x Duroc) gilts were used in two replicates of a randomized complete block experiment to evaluate the effect of dietary feed intake on pubertal onset and subsequent body composition. Feed intakes were established at 50% of ad libitum (AL-50), 75% of ad libitum (AL-75), or at ad libitum (AL-100) levels from 4.5 to 9 mo of age. A corn-soybean meal diet fed to all gilts was formulated to meet or exceed nutrient requirements except for energy. Puberty was measured by two methods: 1) monitored once daily by back pressure applied by the herdsman or 2) from elevated plasma progesterone concentrations. Body composition was evaluated by the deuterium oxide method after plasma progesterone concentrations were elevated. Daily feed intake for the experimental period averaged 1.6, 2.3, and 3.2 kg, and the BW of gilts at 8 mo of age were 111, 131, and 154 kg for the AL-50, AL-75, and AL-100 groups, respectively. Body weight, backfat thickness, and body fat content increased linearly (P < .01) as feed intake increased, but age at puberty was not severely influenced. A minimum body fat content or percentage did not seem to initiate pubertal onset. There was a trend for a lower percentage of the AL-50 gilts to ovulate (P = .08) than those fed the AL-75 and AL-100 intakes. An inverse relationship resulted between the percentage of gilts that ovulated to the percentage that showed behavioral estrus.(ABSTRACT TRUNCATED AT 250 WORDS)  相似文献   

Le personnel     

Jack DC  Matthew B 《The Canadian veterinary journal. La revue veterinaire canadienne》1995,36(7):449-451

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Quelle est la valeur de mon h?pital vétérinaire?          下载免费PDF全文

Matthew B 《The Canadian veterinary journal. La revue veterinaire canadienne》1992,33(7):474-476

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Chromosome and plasmid-encoded N-acyl homoserine lactones produced by Agrobacterium vitis wildtype and mutants that differ in their interactions with grape and tobacco     

Yaxin Li  Matthew R. Gronquist  Guixia Hao  Michele R. Holden  Anatol Eberhard  Russell A. Scott  Michael A. Savka  Erno Szegedi  Sandor Sule  Thomas J. Burr   《Physiological and Molecular Plant Pathology》2005,67(6):101

Agrobacterium vitis causes crown gall disease on grapevines. It also induces a specific necrosis on grape roots and a hypersensitive response (HR) on tobacco that are regulated by a complex quorum-sensing regulatory system. Strain F2/5 produces at least six N-acyl-homoserine lactones (AHLs) that function as signal molecules in quorum-sensing. The AHLs differ in acyl side chain length (8–16 carbons) as determined by gas chromatography/mass spectrometry and electrospray ionization tandem mass spectrometry. Mutant derivatives of F2/5 differ in ability to cause necrosis and the HR and show variable AHL profiles as determined by a thin-layer chromatography/biosensor assay. All wildtype A. vitis strains revealed the presence of long-chain AHLs regardless of tumorigenicity or ability to cause the HR. Whereas genes encoding long-chain AHLs are predicted to reside on the F2/5 chromosome, the determinants for short-chain AHLs were shown to be located on conjugal plasmids.  相似文献   

Molecular diagnosis of paramyxovirus infection in snakes using reverse transcriptase-polymerase chain reaction and complementary deoxyribonucleic acid:ribonucleic acid in situ hybridization.     

Matthew A Sand  Kenneth S Latimer  Christopher R Gregory  Pauline M Rakich  Elliott Jacobson  Kate E Pennick 《Journal of veterinary diagnostic investigation》2004,16(5):442-448

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Analysis of a Secreted Aspartic Peptidase Disruption Mutant of Glomerella cingulata     

Kim M. Plummer  Sarah J. Clark  Lana M. Ellis  Ashwini Loganathan  Taha H. Al-Samarrai  Erik H.A. Rikkerink  Patrick A. Sullivan  Matthew D. Templeton  Peter C. Farley 《European journal of plant pathology / European Foundation for Plant Pathology》2004,110(3):265-274

Peptidases have been implicated in the pathogenicity of fungi that cause disease in plants. Expression of the secreted aspartic peptidase gene (gcsap), of a Glomerella cingulata isolate pathogenic on apples, is induced during appressorium formation. To determine whether the secreted aspartic peptidase (GcSAP) is essential to pathogenicity, gcsap was disrupted using a vector containing a 637 bp fragment of genomic DNA that encodes the sequence spanning the two active site aspartic acid (Asp) residues. To ensure that the truncated gcsap gene products could not have residual peptidase activity the codons for the active site residues Asp¹¹² and Asp²⁹⁷ were both mutated to histidine residues. Both PCR and Southern analysis confirmed disruption of gcsap. Neither gcsap mRNA nor GcSAP activity was detected in the disruption mutant. Pathogenicity tests on fruit from three apple cultivars showed that GcSAP was not required for pathogenicity. The disruption mutant grew on medium containing protein as the sole source of nitrogen because G. cingulata secretes a previously undetected peptidase(s). A serine peptidase that had a pH optimum between pH 7.0 and 8.0 and a K _m of 0.25 mM for the synthetic substrate succinyl-Ala–Ala–Pro–Phe-p-nitroanilide was identified.  相似文献