Marked neutropenia in five tumor-bearing cats one week following single-agent vincristine sulfate chemotherapy     

Hahn KA KA  Fletcher CM  Legendre AM 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》1996,25(4):121-123

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The intensity of resistance by mature Merino ewes against Haemonchus contortus and Tichostrongylus colubriformis in single-species and combined-species infection     

DB ADAMS  JJ LYNCH†  BH ANDERSON  LR FELL‡  GN HINCH§  RK MUNRO¶ 《Australian veterinary journal》1990,67(12):443-445

Three-year-old, non-lactating and non-pregnant Merino ewes, raised on pasture under a program of strategic treatment with anthelmintic and found to be extremely resistant to "trickle" infection with Haemonchus contortus, were given single-dose infections with either H. contortus or Trichostrongylus colubriformis or both species together. The purpose was to ascertain the intensity of protective immunity against the 2 parasites in sheep with immunity acquired from a presumably slight exposure to infection. To provide a criterion, some infected ewes were immunosuppressed with corticosteroid, dexamethasone. Untreated ewes were extremely resistant to challenge infection with either 15,000 or 150,000 H. contortus or 15,000 T. colubriformis. Surprisingly, when mixed infection was given, egg counts for H. contortus were significantly elevated compared with infection by that species alone. Antibody to antigens from infective larval and adult H. contortus was measured in serum by enzyme-linked-immunosorbent assay (ELISA) during the course of infection. Serum titres against larval antigens were significantly depressed when infections with either H. contortus or T. colubriformis were permitted by immunosuppression with dexamethasone, whereas those against adult antigen were depressed when infection with T. colubriformis was permitted.  相似文献   

Ergovaline does not alter the severity of ryegrass staggers induced by lolitrem B     

SC Finch  JB Vlaming  BL Sutherland  C van Koten  WJ Mace  LR Fletcher 《New Zealand veterinary journal》2018,66(2):93-97

AIM: To investigate a possible interaction between lolitrem B and ergovaline by comparing the incidence and severity of ryegrass staggers in sheep grazing ryegrass (Lolium perenne) containing lolitrem B or ryegrass containing both lolitrem B and ergovaline.

METHODS: Ninety lambs, aged approximately 6 months, were grazed on plots of perennial ryegrass infected with either AR98 endophyte (containing lolitrem B), standard endophyte (containing lolitrem B and ergovaline) or no endophyte, for up to 42 days from 2 February 2010. Ten lambs were grazed on three replicate plots per cultivar. Herbage samples were collected for alkaloid analysis and lambs were scored for ryegrass staggers (scores from 0–5) weekly during the study. Any animal which was scored ≥4 was removed from the study.

RESULTS: Concentrations of lolitrem B did not differ between AR98 and standard endophyte-infected pastures during the study period (p=0.26), and ergovaline was present only in standard endophyte pastures. Ryegrass staggers was observed in sheep grazing both the AR98 and standard endophyte plots, with median scores increasing in the third week of the study. Prior to the end of the 42-day grazing period, 22 and 17 animals were removed from the standard endophyte and AR98 plots, respectively, because their staggers scores were ≥4. The cumulative probability of lambs having scores ≥4 did not differ between animals grazing the two pasture types (p=0.41).

CONCLUSIONS AND CLINICAL RELEVANCE: There was no evidence for ergovaline increasing the severity of ryegrass staggers induced by lolitrem B. In situations where the severity of ryegrass staggers appears to be greater than that predicted on the basis of concentrations of lolitrem B, the presence of other tremorgenic alkaloids should be investigated.  相似文献   

Distribution,characteristics and condition of Arctic charr (Salvelinus alpinus) spawning grounds in a differentially eutrophicated twin‐basin lake          下载免费PDF全文

Helen Miller  Ian J. Winfield  Janice M. Fletcher  J. Ben James  Joey van Rijn  Jonathan M. Bull  Carol J. Cotterill 《Ecology of Freshwater Fish》2015,24(1):32-43

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Electroencephalogram of Healthy Horses During Inhaled Anesthesia          下载免费PDF全文

D.C. Williams  M.R. Aleman  R.J. Brosnan  D.J. Fletcher  B. Tharp  P.H. Kass  E.P. Steffey  R.A. LeCouteur 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2016,30(1):304-308

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Measurement of aldosterone in feline, canine and human urine     

Syme HM  Fletcher MG  Bailey SR  Elliott J 《The Journal of small animal practice》2007,48(4):202-208

BACKGROUND: Systemic hypertension is an important problem in older cats associated with kidney disease and hypokalaemia, suggesting that excessive activity of the renin-angiotensin-aldosterone system might contribute to the hypertensive state. Fluctuations in plasma renin activity and plasma aldosterone concentrations complicate the interpretation of these assays. OBJECTIVES: The aim of this study was to determine whether measurement of urinary aldosterone excretion in cats aided the investigation of hypertension. METHODS: Urine concentrations of free (ethyl acetate extract) and 18-glucuronidated aldosterone (acid hydrolysis before extraction) were measured by radioimmunoassay in normal, normotensive and hypertensive azotaemic cats (n=11 per group). Urine samples from 11 healthy human volunteers and eight normal dogs were also analysed for comparison. Urinary aldosterone concentration was corrected for the urinary creatinine concentration. RESULTS: Cats excreted 7.3 times less free aldosterone than human beings, and no free aldosterone was detected in dog urine. Acid hydrolysis led to large increases in aldosterone recovery from both human beings and dog but not feline urine. No significant effect of hypertension or azotaemia on feline urinary aldosterone concentration was found. CLINICAL SIGNIFICANCE: Measurement of aldosterone in feline urine using the available methodology has limited or no utility in investigating feline hypertension.  相似文献   

Modelling control strategies for foot-and-mouth disease     

Fletcher J 《The Veterinary record》2001,149(11):339

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Comparative morphologic features of urinary bladder innervation     

T F Fletcher  W F Bradley 《American journal of veterinary research》1969,30(9):1655-1662

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Electroencephalography in the unanesthetized dog     

R A Herin  P T Purinton  T F Fletcher 《American journal of veterinary research》1968,29(2):329-336

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Glasshouse Fumigation with Formaldehyde   总被引：1，自引：1，他引：0  

J. G. White  J. T. Fletcher 《Plant pathology》1971,20(4):191-194

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