Comparative efficacy of moxidectin, an ivermectin/clorsulon combination and closantel against immature paramphistomes in cattle     

PF ROLFE  JC BORAY 《Australian veterinary journal》1993,70(7):265-266

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"Benchmark" - a large observational study of Ontario beef breeding herds: Study design and collection of data          下载免费PDF全文

McDermott JJ  Alves DM  Anderson NG  Martin SW 《The Canadian veterinary journal. La revue veterinaire canadienne》1991,32(7):407-412

The methods used in a large field study which investigated the health and productivity of Ontario beef breeding herds are described. Beginning in the calving season of 1986, 180 breeding herds on 170 randomly sampled farms were followed for a two year period, using producer records and annual farm visits.

The response (cooperation) rate among the eligible producers initially contacted was 70%. Approximately two-thirds of producers maintained individual animal records, primarily calving season records. Approximately 40% recorded disease occurrences.

The advantages, disadvantages, and interpretation of “on-farm” observational studies are discussed.

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Characterization of multidrug resistant Salmonella recovered from diseased animals     

Zhao S  McDermott PF  White DG  Qaiyumi S  Friedman SL  Abbott JW  Glenn A  Ayers SL  Post KW  Fales WH  Wilson RB  Reggiardo C  Walker RD 《Veterinary microbiology》2007,123(1-3):122-132

Three hundred and eighty Salmonella isolates recovered from animal diagnostic samples obtained from four state veterinary diagnostic laboratories (AZ, NC, MO, and TN) between 2002 and 2003 were tested for antimicrobial susceptibilities and further characterized for bla(CMY) beta-lactamase genes, class 1 integrons and genetic relatedness using PFGE. Forty-seven serovars were identified, the most common being S. Typhimurium (26%), S. Heidelberg (9%), S, Dublin (8%), S. Newport (8%), S. Derby (7%), and S. Choleraesuis (7%). Three hundred and thirteen (82%) isolates were resistant to at least one antimicrobial, and 265 (70%) to three or more antimicrobials. Resistance was most often observed to tetracycline (78%), followed by streptomycin (73%), sulfamethoxazole (68%), and ampicillin (54%), and to a lesser extent chloramphenicol (37%), kanamycin (37%), amoxicillin-clavulanic acid (20%), and ceftiofur (17%). With regards to animal of origin, swine Salmonella isolates displayed the highest rate of resistance, being resistant to at least one antimicrobial (92%), followed by those recovered from turkey (91%), cattle (77%), chicken (68%), and equine (20%). Serovars commonly showing multidrug resistance (MDR) to > or =9 antimicrobials were S. Uganda (100%), S. Agona (79%), and S. Newport (62%), compared to S. Heidelberg (11%) and S. Typhimurium (7%). Class-1 integrons were detected in 43% of all isolates, and were found to contain aadA, aadB, dhfr, cmlA and sat1 gene cassettes alone or in various combinations. All ceftiofur resistant isolates (n=66) carried the bla(CMY) beta-lactamase gene. A total of 230 PFGE patterns were generated among the 380 isolates tested using XbaI, indicating extensive genetic diversity across recovered Salmonella serovars, however, several MDR clones were repeatedly recovered from different diseased animals.  相似文献   

Can epidemiology and economics make a meaningful contribution to national animal-disease control?     

Perry B  McDermott J  Randolph T 《Preventive veterinary medicine》2001,48(4):1177-260

The general role of veterinary epidemiology and economics to national animal-disease control throughout the world is considered for the four main groupings of animal diseases: zoonotic, food-borne, endemic and epidemic diseases. This is done by considering how veterinary epidemiology and economics has contributed to priority setting (which diseases come first?), decision-making (for a given disease, which strategy is best?), and disease control implementation (how can optimal delivery and adoption of selected interventions best be achieved?). Within each of these categories, progress made and future opportunities are discussed. In addition, a review is made of how veterinary epidemiology and economics has been institutionalised. We conclude that veterinary epidemiology and economics holds a unique role in the development of national policies and strategies for improved animal health world-wide. However, we consider that we must capitalise more on the unique comparative advantage of the partnership between veterinarians and agricultural economists. We believe that much remains to be done to improve the "institutionalisation" of veterinary epidemiology and economics, and the adoption and impact of the products of our unique partnership, particularly in countries of the developing world.  相似文献   

The impact of Theileria parva infections and other factors on calf mean daily weight gains in smallholder dairy farms in Murang'a District, Kenya     

Gitau GK  McDermott JJ  McDermott B  Perry BD 《Preventive veterinary medicine》2001,51(3-4):149-160

The association between mean daily weight gain, Theileria parva infections, clinical East Coast fever and other possible determinants of weight gain were examined in a longitudinal observational study that was conducted in cohorts of female calves from five agro-ecological zone (AEZ)-grazing strata. The strata were upper-midlands (UM) 1 zero-grazing, UM 1 open-grazing, UM 2 zero-grazing, UM 4 zero-grazing and UM 4 open-grazing. In total, 225 calves on 188 smallholder dairy farms were visited within the first 2 weeks of life and thereafter at biweekly intervals up to the age of 6 months between March 1995 and August 1996. During each visit, the calves were weighed and other calf-management practices in the farm during the visit such as housing, feeding and tick control also were recorded. Other events such as morbidity and mortality between or during the visits were also recorded.

The overall mean daily weight gains were 0.24–0.29 kg (S.D.=0.17–0.22 kg) and were lower than the recommended targets for smallholder farms of 0.40–0.50 kg. The major tendency in variability of daily weight gains was due to visit-to-visit variation (especially in calves >3 months old).

Differences in mean daily gains were associated with AEZ-grazing strata and calf-level factors that included breed of calf, calf sickness, incidence of ECF, feeding of milk, concentrate feeds and minerals and interaction between calf age and AEZ-grazing strata (P<0.05). ECF and other calf sicknesses exerted a temporal effect on calf-growth at the height of illness and immediately after; calves later recovered the lost growth except where other factors such as poor calf nutrition prevailed. Improvement in calf-growth in Murang’a District is achievable and extension services should continue to target individual-calf-level management practices.  相似文献   

Impact of Mastitis Control Measures on Milk Production and Mastitis Indicators in Smallholder Dairy Farms in Kiambu District,Kenya   总被引：1，自引：1，他引：0  

Omore AO  McDermott JJ  Arimi SM  Kyule MN 《Tropical animal health and production》1999,31(6):347-361

Bovine mastitis and mastitis control were investigated on smallholder farms in central Kenya. After an initial observational study, a clinical trial to assess the impact of three different mastitis control strategies – (1) improved udder hygiene, (2) treatment of subclinical cases, and (3) a combination of these – was conducted on 100 randomly selected farms with 332 lactating cows. Before the implementation of control measures, the milk yield was low (mean 6.5 kg/day; median 6 kg/day) and somatic cell counts (SCC) were high, with 80% and 43% of cows having milk with SCC greater than 250×10³ cells/ml and 600×10³ cells/ml, respectively. Infectious pathogens were also commonly isolated, with 63% of cows being positive for pathogenic bacteria. Neither intervention strategy alone had any effect on mastitis indicators or milk yield. In combination, the measures had some impact, lowering the prevalence of contagious pathogens by 18%, but this was not reflected in a significantly increased milk yield, lowered SCC or reduced incidence of clinical mastitis.  相似文献   

The incidence, calf morbidity and mortality due to Theileria parva infections in smallholder dairy farms in Murang'a District, Kenya   总被引：1，自引：0，他引：1  

Gitau GK  Perry BD  McDermott JJ 《Preventive veterinary medicine》1999,39(1):65-79

A prospective observational study was conducted among smallholder dairy farmers in Murang'a District, Kenya, to estimate the incidence of Theileria parva infections, as well as calf morbidity and mortality caused by the infection. The study was conducted between March 1995 and August 1996, in five cohorts of female calves from birth to six months of age from different agro-ecological zones (AEZs) and grazing-system strata shown previously to have varying prevalences of T. parva infection. A total of 188 smallholder dairy farms with 225 female calves were selected purposively by five AEZ-grazing strata. All recruited calves were visited within the first two weeks of life and thereafter at biweekly intervals up to the age of six months. The mean number of cattle in these smallholder farms was 2.6. Both exotic and indigenous breeds of cattle and their crosses were present, with the former predominating. The incidence (27-54%) of sero-conversion to T. parva in an ELISA test was significantly different (p < 0.05) across the five AEZ-grazing strata and increased with lower elevation and unrestricted grazing. Calf morbidity and mortality were also variable across the AEZ-grazing strata. East Coast fever (ECF) was the highest-incidence cause calf morbidity and mortality (relative to other diseases). There are great differences in the epidemiology of ECF within a small area and this implies that there is need to carefully consider different ECF control strategies in different AEZ-grazing strata.  相似文献   

Analysis of correlated continuous repeated observations: modelling the effect of ketosis on milk yield in dairy cows   总被引：3，自引：0，他引：3  

Gröhn YT  McDermott JJ  Schukken YH  Hertl JA  Eicker SW 《Preventive veterinary medicine》1999,39(2):137-153

This study used mixed models analysis to demonstrate the advantages of a repeated measures technique for a continuous variable over a single measure technique. As an illustration, the loss of milk yield due to ketosis was studied in 2604 multiparous New York State Holstein cows belonging to eight herds, calving between 1991 and 1993. Two methods of analysis were presented: The first treated milk yield as a continuous, summary measure (projected 305-day milk yield); the second treated milk yield as repeated measurements (test-day milk yields). In the first example, with 305-day milk yield as the outcome, ketosis was treated as a binary covariate. Ketosis had no effect on the 305-day milk yield. In the second example, with monthly test-day milk yields as the outcome, four different covariance structures (simple, compound symmetry, autoregressive, and unstructured) to model the association among the repeated measurements were compared. With this approach, ketotic cows yielded significantly less milk per day both before and immediately after diagnosis than did non-ketotic cows. Based on the goodness-of-fit statistics, it was unclear whether an autoregressive or unstructured covariance structure was best. However, an autoregressive structure, in which the previous and current test-day milk yields are assumed to be correlated, was considered more suitable in this study; it is a simpler and more appropriate covariance structure for this particular problem than is an unstructured covariance structure. Nevertheless, with the test-day approach, any of these correlation structures could be used to estimate milk loss after disease. Based on these findings, it is recommended that a repeated measures approach, rather than a single measure approach, be used to study the short-term effect of disease on milk yield.  相似文献   

Cloning,expression, purification,and biological activity of five feline type I interferons   总被引：1，自引：0，他引：1  

Wonderling R  Powell T  Baldwin S  Morales T  Snyder S  Keiser K  Hunter S  Best E  McDermott MJ  Milhausen M 《Veterinary immunology and immunopathology》2002,89(1-2):13-27

Type I interferons (IFN) are important mediators of the host defense against viral infections in mammals. In humans multiple subtypes of IFN-alpha exist, most of which possess antiviral activity. Little is known about the type I IFN genes in cats and the role they may play in feline immunological responses to viruses. We have isolated cDNAs encoding five feline IFN-alpha (feIFN) subtypes that share from 95 to 99% amino acid sequence identity. FeIFN-alpha5 has five additional amino acids inserted at position 139, which are not present in the other four subtypes. Sequence identity of the feIFN proteins encoded by the five clones compared to human IFN-alpha2 is approximately 60%. Unlike most of the human subtypes, each of the five feline IFN sequences has an N-glycosylation recognition site. Expression of all five feIFN-alpha subtypes in Chinese hamster ovary (CHO) cells was confirmed by Western blot analysis, and all resulting proteins were glycosylated. The antiviral activity of each feIFN-alpha subtype produced in transiently transfected CHO cell cultures was tested in vitro. In addition, subtype feIFN-alpha6 was expressed in the yeast, Pichia pastoris. The resulting secreted mature recombinant protein was purified and demonstrated significant antiviral activity and induction of 2',5'-oligoadenylate synthetase activity in vitro.  相似文献   

Use of Akaike information criteria for model selection and inference. An application to assess prevention of gastrointestinal parasitism and respiratory mortality of Guinean goats in Kolda,Senegal     

Lancelot R  Lesnoff M  McDermott JJ 《Preventive veterinary medicine》2002,55(4):993-240

A field experiment was carried out in Kolda (southern Senegal) from July 1986 to July 1988. Its goals were to: (1) describe the patterns of mortality of female Guinean goats by age, season and year; (2) assess preventive measures against respiratory diseases and gastrointestinal parasitism in reducing mortality; and (3) estimate the overall impact of these measures on survival to 1 year of age. Preventive measures for respiratory disease included vaccination against peste des petits ruminants (PPR) and pneumonic pasteurellosis (Pasteurella multocida types A and D). Control of gastrointestinal parasites was by deworming does with morantel (7.5 mg kg⁻¹, three times during the rainy season). The effects of vaccines and deworming were tested in a randomised factorial field experiment with villages being the experimental units. A total of 19 villages, 113 goat herds and 1458 goats were included in the study.

Generalised linear models of survival for five cohorts of goats (defined by five different birth seasons) used a binomial assumption for the response distribution and a complementary log–log link. Explanatory variables included age, season, year, vaccination, deworming and their interactions. A complex a priori model was built on the basis of previous epidemiological knowledge; a purposively selected set of simpler models was compared to this full model by the Akaike information criterion (AIC) and derived statistics. Inference on 1-year survival and treatment effects accounted for model-selection uncertainty. It was carried out with a bootstrap procedure and used information from the whole set of selected models.

Large variations in mortality by year and season were observed but no regular seasonal pattern was apparent. Mortality probabilities of kids in dewormed groups decreased quickly after birth, but remained elevated up to 9 months of age in the non-dewormed groups. Deworming lowered the risk of mortality. Vaccination alone was not protective (except during an observed outbreak of PPR).  相似文献