Pharmacokinetics of Enrofloxacin and Its Metabolite Ciprofloxacin after Intramuscular Administration of Enrofloxacin in Goats     

Rao GS  Ramesh S  Ahmad AH  Tripathi HC  Sharma LD  Malik JK 《Veterinary research communications》2001,25(3):197-204

The pharmacokinetics of enrofloxacin and its active metabolite ciprofloxacin were investigated in goats after a single intramuscular administration of enrofloxacin at 2.5 mg/kg body weight. The plasma concentrations of enrofloxacin and ciprofloxacin were determined simultaneously by a HPLC method. The peak concentrations (C _max) of enrofloxacin (1.13 g/ml) and ciprofloxacin (0.24 g/ml) were observed at 0.8 and 1.2 h, respectively. The elimination half-life (t _1/2), volume of distribution (V _d(area)), total body clearance (Cl_B) and mean residence time (MRT) of enrofloxacin were 0.74 h, 1.42 L/kg, 1329 ml/h per kg and 1.54 h, respectively. The t _1/2, area under the plasma concentration–time curve (AUC) and the MRT of ciprofloxacin were 1.38 h, 0.74 g h/ml and 2.73 h, respectively. The metabolic conversion of enrofloxacin to ciprofloxacin was appreciable (36%) and the sum of the plasma concentrations of enrofloxacin and ciprofloxacin was maintained at or above 0.1 g/ml for up to 4 h. Enrofloxacin appears to be useful for the treatment of goat diseases associated with pathogens sensitive to this drug.  相似文献   

Factors affecting urine reagent strip blood results in dogs and nonhuman primates and interpretation of urinalysis in preclinical toxicology studies: a Multi‐Institution Contract Research Organization and BioPharmaceutical Company Perspective          下载免费PDF全文

Adam D. Aulbach  Eric Schultze  Niraj K. Tripathi  Robert L. Hall  Michael R. Logan  Denny J. Meyer 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2015,44(2):229-233

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Understanding genetic diversity in blackgram [Vigna mungo (L.) Hepper] collections of Indian National Genebank     

Gayacharan  Tripathi  Kuldeep  Aski  Muraleedhar S.  Singh  Neeta  Kumar  Ashok  Lal  Hanuman 《Genetic Resources and Crop Evolution》2022,69(3):1229-1245

Genetic Resources and Crop Evolution - Blackgram [Vigna mungo (L.) Hepper] is a protein rich pulse crop of Indian origin. The crop is cultivated in diverse range of agro-ecological regions,...  相似文献   

Cryptosporidium infection in a dugong (Dugong dugon)     

BD HILL  IR FRASER  HC PRIOR 《Australian veterinary journal》1997,75(9):670-671

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Inheritance studies of characters associated with floating habit and their linkage relationship in rice     

R. S. Tripathi  M. J. Balakrishna Rao 《Euphytica》1985,34(3):875-881

Summary Deep water rice varieties in general have certain peculiar characters which are associated with floating habit. These characters are (i) early nodal differentiation, (ii) nodal rooting, (iii) spreading habit, (iv) awned grains, (v) brown hull colour, (vi) red pericarp (red rice), and (vii) seed dormancy. Inheritance of these characters and linkage relationship of genes governing these characters were studied in a cross between Pankaj (non floating) and Nageribao (floating) rice varieties. Nageribao, a cultivar from Assam possesses these characters.Early nodal differentiation was observed to be controlled by a single dominant gene, designated as Nd. Nodal rooting was controlled by two dominant complementary genes, designated as Nr ₁ and Nr ₂. We found an inhibitory factor for spreading habit and one for brown hull colour in Pankaj; the operation of two dominant duplicate genes An ₁ and An ₂ for controlling awning characters, a single dominant gene Rd for red pericarp colour and a single dominant gene Gd for grain dormancy. Joint segregations between these characters resulted in the assignment of genes in the X linkage group of indica rices with estimated map distances based on the cross-over values. The genes An (awning), Es (spreading habit), Nr (nodal rooting) and Nd (nodal differentiation) were observed to be associated with each other. The gene for red pericarp (Rd) was observed to be linked with the grain dormaney gene Gd.  相似文献   

Thermal Infrared Radiation for Assessing Crop Water Stress in Wheat   总被引：1，自引：0，他引：1  

Alok  Kumar R. P. Tripathi 《Journal of Agronomy and Crop Science》1990,165(4):268-272

Field studies on differentially irrigated wheat ( Triticum aestivum L.) crops were conducted at Pantnagar for two years to evaluate the use of thermal infrared radiation to detect crop water stress. Data show that the stress-degree-day index (mid day canopy-air temperature difference) is influenced by environmental variability other than soil moisture. Improvement in the stress-degree-day (SDD) index was achieved by including the measurements of vapor pressure deficit and approach was termed as plant water stress index (PWSI). Observations indicated that daily variation in SDD values due to meteorological changes was removed through PWSI. Better correlation was found between soil-induced leaf water potential and plant water stress index than between total leaf water potential and plant water stress index. It is concluded that remote sensing of thermal infrared radiation offers a promising technique which can be incorporated into irrigation management programme.  相似文献   

Growth and reproduction of the vermicomposting earthwormPerionyx excavatus as influenced by food materials     

M. C. Manna  M. Singh  S. Kundu  A. K. Tripathi  P. N. Takkar 《Biology and Fertility of Soils》1997,24(1):129-132

An outdoor study was undertaken using polyethylene containers to assess the suitability of different organic residues, soybean straw (Glycine max L. Merril.), wheat straw (Triticum aestivum L.), maize stover (Zea mays L.), chickpea straw (citer arietinum L.) and city garbage, as food for the tropical epigeic earthwormPerionyx excavatus, and to assess the influence of this earthworm on the decomposition of these materials. Maize stover was found to be the most suitable of the food materials used. Population growth ofP. excavatus was enhanced by addition of these organic materials in the temperature range 24°-30°C, while the population was adversely affected above 30°C in a vermiculture system. Addition of earthworms accelerated the breakdown of residues, which ultimately resulted in a lowering of the C:N ratio, water-soluble carbon and carbohydrates, and increased ash percentage and cation exchange capacity compared with their respective controls.  相似文献   

Influence of tillage and crop residue on soil physical properties and yields of rice and wheat under shallow water table conditions     

R.P. Tripathi  PeeyushSharma  Surendra Singh 《Soil & Tillage Research》2007,92(1-2):221-226

An experiment was conducted to evaluate the effects of tillage and residue incorporation on soil properties and yields of rice (Oryza sativa L.) and wheat (Triticum aestivum L.) in rotation for 4 years on a silty clay loam of an Aquic Hapludoll with natural water table fluctuating between 0.05 and 0.97 m depth The rice experiment was laid out in split plot design with four levels of tillage, viz. conventional puddling (CP), puddling by four passes of rotavator (PR), reduced puddling by two passes of rotavator (ReP), and direct seeding without puddling (DSWP) and two levels of residue, viz. residue incorporation (RI) and residue removal (RR) in four replications. The treatments for wheat were zero tillage (ZT) and conventional tillage (CT) with RI and RR superimposed over the plots of rice. Tillage for rice increased puddling index and bulk density (BD) over the years. The increase was significantly higher in CP and PR than in ReP. In wheat season, BD was higher under ZT than under CT but the differences were not significant. Puddling decreased saturated hydraulic conductivity with time, which became significantly lower in CP and PR in the fourth year than in ReP in the first year. Infiltration rate (IR) also decreased with time and was lowest in CP and PR. In wheat season, IR was at par under ZT and CT. Rice yield in PR was maximum and at par with that in ReP. But wheat yield was lowest in PR and highest in DSWP, and was at par in DSWP and ReP. Thus, rice yields were optimum under ReP, in which changes in soil properties were least, and wheat yields were optimum both under ZT and CT in the DSWP and ReP plots of rice under shallow water table conditions of the silty clay loam.  相似文献   

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis   总被引：1，自引：0，他引：1  

Sreedharan J  Blair IP  Tripathi VB  Hu X  Vance C  Rogelj B  Ackerley S  Durnall JC  Williams KL  Buratti E  Baralle F  de Belleroche J  Mitchell JD  Leigh PN  Al-Chalabi A  Miller CC  Nicholson G  Shaw CE 《Science (New York, N.Y.)》2008,319(5870):1668-1672

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder characterized pathologically by ubiquitinated TAR DNA binding protein (TDP-43) inclusions. The function of TDP-43 in the nervous system is uncertain, and a mechanistic role in neurodegeneration remains speculative. We identified neighboring mutations in a highly conserved region of TARDBP in sporadic and familial ALS cases. TARDBPM337V segregated with disease within one kindred and a genome-wide scan confirmed that linkage was restricted to chromosome 1p36, which contains the TARDBP locus. Mutant forms of TDP-43 fragmented in vitro more readily than wild type and, in vivo, caused neural apoptosis and developmental delay in the chick embryo. Our evidence suggests a pathophysiological link between TDP-43 and ALS.  相似文献   

Disease of geese caused by a new herpesvirus   总被引：3，自引：0，他引：3  

PJ KETTERER  BJ RODWELL  HA WESTBURY†  PT HOOPER†  AR MACKENZIE‡  JG DINGLE§  HC PRIOR 《Australian veterinary journal》1990,67(12):446-448

A goose flock farmed outdoors in south-eastern Queensland suffered an outbreak of peracute disease with high death rate (97%). Small button ulcers and large plaques overlying lymphocyte aggregates were present on the mucosa of the small intestine of affected birds. Small white foci of necrosis and focal haemorrhages were seen in the livers. Numerous intranuclear inclusion bodies were observed microscopically in hepatocytes and a herpesvirus which grew rapidly in chicken kidney cells was isolated from tissues. Duck virus enteritis (DVE) was suspected but DVE antiserums failed to neutralise the virus. Further serological studies with a limited range of known avian herpesviruses have failed to identify the virus. Experimental transmission resulted in high mortality in geese (100%), lower mortality in ducklings and nil mortality in chickens. Surveillance studies showed no evidence of infection in domestic and wild birds beyond the original farm and the infection appears not to have been established in the area. Wild ducks, which were frequent visitors to the farm dam, were considered the most likely source of the infection.  相似文献