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1.
Six cats with an advanced stage squamous cell carcinoma (SCC) of the nasal planum were treated with a combination of superficial radiotherapy and intralesional carboplatin therapy. This multimodality protocol was well tolerated by the majority of cats and resulted in complete responses in all cats (100%). Median follow‐up for all cats is 268 days, and the median time‐to‐recurrence, time‐to‐progression and overall survival have not yet been reached. Our study, although limited in number of animals and with a relatively short median follow‐up compared to other studies for this disease, suggests that a combination of radiotherapy and intralesional carboplatin is a useful treatment option for an advanced stage SCC of the nasal planum in cats and warrants further application of the multimodality approach presented here. 相似文献
2.
Diego A. Portela Marta Romano Gustavo A. Zamora Fernando Garcia-Pereira Luisito S. Pablo Bonnie J. Gatson Alana N. Johnson Pablo E. Otero 《Veterinary anaesthesia and analgesia》2021,48(1):116-124
ObjectiveTo compare the perioperative use of analgesics and complication rates in dogs administered an erector spinae plane (ESP) block or a traditional opioid-based (OP) treatment as part of analgesic management during hemilaminectomy.Study designRetrospective cohort study.AnimalsMedical records of 114 client-owned dogs.MethodsGeneral data included demographics, duration of procedure, number of laminae fenestrated, perioperative use of steroid and non-steroidal anti-inflammatory drugs. Intra- and postoperative analgesics used in 48 hours and complications rates were compared between groups. Opioid use was expressed in morphine equivalents [ME (mg kg?1)]. Continuous data were compared using the Mann–Whitney U test and incidence of events with a Fisher's exact tests. Multiple linear regression was used to evaluate association between perioperative ME consumption (dependent variable) with other independent variables. Data are presented as median (range). Differences were considered significant when p < 0.05.ResultsGroup ESP comprised 42 dogs and group OP 72 dogs. No differences were observed in the general data. Intraoperative ME was 0.65 (0.20–3.74) and 0.79 (0.19–5.60) mg kg?1 in groups ESP and OP, respectively (p = 0.03). Intraoperative infusion of lidocaine was administered intravenously (IV) to 23.8% and 68% of groups ESP and OP, respectively (p < 0.0001). Intraoperative infusion of ketamine was administered IV to 21% and 40% of groups ESP and OP, respectively (p = 0.04). Regression analysis revealed the ESP block as the only independent variable affecting the perioperative ME consumption. Pharmacological intervention to treat cardiovascular complications was administered to 21.4% and 47.2% of dogs in groups ESP and OP, respectively (p = 0.008). There were no differences in postoperative complication rates.Conclusions and clinical relevanceESP block was associated with reduced perioperative opioid consumption, intraoperative adjuvant analgesic use and incidence of pharmacological interventions to treat cardiovascular complications in dogs undergoing hemilaminectomy. 相似文献
3.
《Veterinary anaesthesia and analgesia》2023,50(5):439-445
ObjectiveTo describe the gross and ultrasound anatomy of the parasacral region and an ultrasound-guided greater ischiatic notch (GIN) plane approach aimed at staining the lumbosacral trunk (LST) in canine cadavers. To evaluate if the ultrasound-guided GIN plane approach is non-inferior to the previously described ultrasound-guided parasacral approach at staining the LST.Study designProspective, randomized, non-inferiority experimental anatomic study.AnimalsA total of 17 (23.9 ± 5.2 kg) mesocephalic canine cadavers.MethodsAnatomic and echographic landmarks, and the feasibility of performing a GIN plane technique were evaluated using two canine cadavers. The remaining 15 cadavers had each hemipelvis randomly assigned to be administered either parasacral or GIN plane injection of 0.15 mL kg–1 dye solution. The parasacral region was dissected after injections to assess the staining of LST, cranial gluteal nerve, pararectal fossa and pelvic cavity. The stained LST were removed and processed for histological evaluation of intraneural injections. A one-sided z-test for non-inferiority (non-inferiority margin –14%) was used to statistically evaluate the success of the GIN plane versus the parasacral approach. Data were considered statistically significant when p < 0.05.ResultsThe GIN plane and parasacral approach stained the LST in 100% and 93.3% of the injections, respectively. The success rate difference between treatments was 6.7% [95% confidence interval, –0.6 to 19.0%; p < 0.001 for non-inferiority]. The GIN plane and parasacral injections stained the LST for 32.7 ± 16.8 mm and 43.1 ± 24.3 mm, respectively (p = 0.18). No evidence of intraneural injection was found.Conclusions and clinical relevanceThe ultrasound-guided GIN plane technique resulted in nerve staining that was non-inferior to the parasacral technique and may be considered an alternative to the parasacral approach to block the LST in dogs. 相似文献
4.
The colored patterns on arbitrary cut plane is an important method in 3D data-field visualization of finite element.By using the technology of the Object-Oriented Programming and the method of scan-line,the colored patterns on arbitrary cut plane are given.The example by the OPENGL of Visual C++ R6 can support the theory satisfactorily. 相似文献
5.
Li Jianping Zhang Wanping Chen Tinghuai Shu Wenzhi 《保鲜与加工》1997,(2):63-68
Based on the optimal control theory and Lagrange interpolation an optimal design model of plane cascades of 3D blade in an arbitrary surface of revolution is established. Using wavelet theory to solve the model, and lots of numerical results are obtained. The results show that the wavelet method is more effective than the conventional methods. 相似文献
6.
The influenfial factors of stratification plane to smooth blasting are studied according to the ti eory of smooth blasting and the anslysis of static stress. The results show that the angle p between the maximum principal plane and the rertical line of stratification plane has some influence on the fracture of rock masses. 相似文献
8.
针对平面应变条件下各向异性砂土剪切带角度的试验规律,采用传统的3种理论和分叉理论进行对比分析。将平面应变条件下剪切带角度的试验结果按照传统3种理论整理发现,尽管传统3种理论可以估算同种砂剪切带角度的极小、中间和极大值,但无法解释其各向异性规律。砂土在平面应变条件下破坏时会产生明显的剪切带,当剪切带方向和砂土沉积面方向接近时,会较早诱发剪切带的产生,使材料强度降低,造成了平面应变条件下各向异性强度规律明显不同于常规三轴条件下的试验规律,采用分叉理论结合各向异性模型则可以有效解释这个规律。随砂土沉积面角度的变化,模型可以从细观角度解释常规三轴条件下剪切带角度的单调变化的试验规律,结合分叉理论可以描述平面应变条件下其先减小然后增大的规律。通过几种理论对比分析表明,模型结合分叉理论不但能够描述多种应力状态下的平面应变和常规三轴应力条件下剪切带角度表现的不同规律,而且能够从细观角度解释其各向异性成因。 相似文献
9.
叙述了有限元技术在疲劳寿命预测中的应用和一般的分析过程;着重介绍了疲劳载荷历程的合成规则和表面节点应力状态的判断方法;归纳评述了常用的多轴疲劳损伤模型;针对结构中普遍存在的焊缝焊点给出了具体的疲劳寿命分析方法;最后给出驱动桥壳疲劳寿命分析实例,计算结果和试验数据基本一致,说明基于有限元法的疲劳寿命预测是切实可行的,可以降低成本,缩短研发周期。 相似文献
10.