Decreased transport of orally administered protein into the blood circulation of developing juveniles of Japanese eel Anguilla japonica     

Osamu Nakamura  Yuzuru Suzuki  Katsumi Aida  Hajime Hatta 《Fisheries Science》2001,67(5):863-869

ABSTRACT: To clarify the quantitative changes in the transport of orally intubated protein into the blood circulation as macromolecules in development, immunoglobulin Y (IgY) extracted from chicken eggs was administered orally to juvenile Japanese eel, Anguilla japonica . For the first experiment, which was performed before the commencement of artificial feeding, the oral delivery of 2.0 μg/0.1 g bodyweight of IgY resulted in a rapid increase in plasma IgY to a maximum of 2.30 μg/mL. However, the transport of IgY into the blood decreased significantly in the experiments that followed, which were performed after 12, 25 and 42 days. During this period, bodyweight increased approximately by a factor of eight, and rapid growth of the stomach was observed histologically. Possible contributions for the development of the alimentary canal to the diminishment of intestinal protein assimilation are discussed.  相似文献   

Comparative pharmacokinetics and bioavailability of oxytetracycline in giant tiger prawn     

Koolvara  SANGRUNGRUANG  Amornthep  CHOTCHUANG  Ryuji  UENO 《Fisheries Science》2004,70(3):467-472

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贵州省林业行政案件发生的主要原因分析及对策探讨   总被引：3，自引：0，他引：3  

钟黔春 《林业资源管理》2006,(1):16-19

对贵州省“十五”林业行政案件发生的原因进行了认真分析,并就进一步加强和改进森林资源保护管理及林业行政执法工作进行了初步探讨。  相似文献   

广西鹿寨县耕地质量等别调查与评价     

尹晋磊  任艳  陈兰康  尹秋月 《安徽农业科学》2016,44(25)

以鹿寨县为列,介绍了广西自治区县级耕地质量等别评价方法,详细分析了耕地质量等别评价结果,揭示了鹿寨县耕地质量等别结构和空间分布规律。  相似文献   

抛物线形混凝土衬砌渠道标准化结构形式研究   总被引：1，自引：0，他引：1  

何武全  宋清林  宋江涛  姜攀  张伟 《灌溉排水学报》2016,(5):10-14

通过实例比较了2种常用的抛物线形渠道水力最佳断面参数,得出二次抛物线渠道的水力性能优于半立方抛物线形渠道,并推导出了二次抛物线渠道实用经济断面的计算公式,提出了详细的计算步骤,给出了二次抛物线渠道实用经济断面水力计算表以供设计人员使用。同时,根据渠道工程实际应用情况和现行规范要求,提出了抛物线形混凝土衬砌渠道标准化结构形式,计算得出了常用抛物线形混凝土渠道结构尺寸、不同比降流量表,在实际工程应用中可根据设计渠道的具体情况进行选用。  相似文献   

经络穴位给药系统在兽医临床上的应用   总被引：1，自引：0，他引：1  

吴帅成  宋舟  张翠  秦倩倩  谢闪闪  张长帅  付本懂  韦旭斌  申海清 《动物医学进展》2011,32(7):109-112

经络穴位给药系统以中医经络理论为基础,具有经穴效应和药物效应的双重治疗特性,已广泛应用于兽医临床.目前,兽医临床上常用穴位给药方式是穴位埋植和穴位注射,而常用穴位主要是后海穴、百会穴、肺龠穴.随着经络穴位给药系统的广泛应用,新型经络穴位给药制剂和经络穴位给药作用机理已成为经络穴位给药系统研究的重点.  相似文献   

我国和欧盟兽药质量监督抽检工作机制对比研究     

张秀英  吴好庭  张骊  李美花  李宁  李琰  娜琳  王小慈  张存帅 《中国兽药杂志》2021,55(1):64-69

为更好地完善我国兽药质量监督抽检计划,通过对欧盟药品抽检管理工作机制的研究,本文分析了欧盟和我国兽药监督抽检管理方式的不同,从抽检责任部门、抽检目的、抽检计划内容、抽检计划制定流程、抽检品种的遴选和检测参数的确定等6方面进行了对比分析,探讨我国兽药质量监督抽检工作的管理中可以借鉴的方面。  相似文献   

Clinical and pharmacokinetic characteristics of intracavitary administration of pegylated liposomal encapsulated doxorubicin in dogs with splenic hemangiosarcoma     

Sorenmo K  Samluk M  Clifford C  Baez J  Barrett JS  Poppenga R  Overley B  Skorupski K  Oberthaler K  Van Winkle T  Seiler G  Shofer F 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2007,21(6):1347-1354

BACKGROUND: Canine splenic hemangiosarcoma (HSA) is a fatal malignancy, and most affected dogs die within a few months of diagnosis. Most dogs present with signs from tumor rupture, resulting in hemoabdomen and intra-abdominal dissemination. The abdomen is also the main site of disease recurrence. HYPOTHESIS: Intraperitoneal (IP) administration of doxorubicin will delay or prevent intra-abdominal tumor recurrence and prolong survival in dogs with HSA. ANIMALS: Fourteen dogs with splenic HSA. METHODS: A prospective, unmasked, uncontrolled clinical trial. After staging of disease status and splenectomy, pegylated liposomal encapsulated doxorubicin was administered intraperitoneally (1 mg/kg body weight) every 3 weeks for 4 cycles. All dogs were monitored for recurrence of HSA. Samples of plasma and abdominal fluid were collected for measurement of doxorubicin concentration and pharmacokinetic analysis. Nonlinear mixed-effect modeling was used to describe the pharmacokinetics of liposomal doxorubicin administered IP. RESULTS: All 14 dogs died, 12 because of HSA and 2 from other causes. Postmortem examination was performed on 12 dogs. All 12 dogs died because of HSA-related causes and had hepatic metastases and hemoabdomen. The IP-treated dogs had fewer serosal, mesenteric, and omental metastases than historical controls treated with systemic doxorubicin. Results of the postmortem examination and pharmacokinetic analysis confirmed that IP delivery of doxorubicin resulted in an effective drug concentration with a clearance comparable with that after i.v. delivery. CONCLUSIONS AND CLINICAL IMPORTANCE: IP pegylated liposomal encapsulated doxorubicin administration did not prevent intraabdominal recurrence of HSA in dogs.  相似文献   

推广草地畜牧业标准化技术促进晴隆县草地畜牧业大发展   总被引：1，自引：0，他引：1  

毛继恩  李涛  张大权 《贵州农业科学》2006,34(3):77-79

为加快农民脱贫致富步伐,晴隆县委、县政府在深化县情认识的基础上,决定把草地畜牧业作为农业和农村产业结构调整的重点,作为农民增收的重头来抓。晴隆县在草地畜牧业发展中,通过切实加强领导、政府办示范、依靠科技进步促发展、大力培育和扶持龙头企业的发展、多渠道筹集资金、抓好技术服务网络建设等做法,选准了一条适合晴隆县草地畜牧业发展的路子,取得了可喜的成绩。  相似文献   

第31届亚太植物保护委员会农药管理情况概述     

张宏军  魏启文 《农药科学与管理》2020,41(3):1-4

本文概述了亚太区域植保委员会第31届大会的基本情况、有关农药管理的交流情况及农药管理执行委员会2020~2021的工作计划,并根据大会议题和我国生产实际,提出了几点建议:有必要协调亚太区域的安全科学用药,开展农药飞防施药技术培训,推动我国农药的出口;有必要加大以农药风险评估为核心的技术培训与输出,推动我国过剩产能走出去;有必要加强农药专业技术国际型人才的培养与输出,增强我国在国际组织中的影响力与话语权。  相似文献