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【目的】研究清肺止咳颗粒的止咳、解热、抗炎以及急性毒性作用。【方法】用浓氨水诱导制作小鼠咳嗽模型,观察清肺止咳颗粒对模型小鼠的镇咳作用;采用蛋白胨制作家兔发热模型,观察清肺止咳颗粒对发热家兔的解热作用;采用二甲苯致炎法制作小鼠耳廓炎症模型,观察清肺止咳颗粒的抗炎作用;测定清肺止咳颗粒小鼠灌服给药的急性毒性。【结果】清肺止咳颗粒可明显延长浓氨水引起小鼠咳嗽的潜伏期,并可减少小鼠2 min内咳嗽的次数;清肺止咳颗粒可显著抑制蛋白胨引起的家兔体温升高,并对由二甲苯引起的小鼠耳廓肿胀有明显的抑制作用;急性毒性试验中未观察到明显的毒性反应,小鼠最大耐受量为320g/kg。【结论】清肺止咳颗粒具有显著的清热止咳作用,且毒性较小。 相似文献
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CHENG Long XIN Rui-hua LUO Yong-jiang WANG Gui-bo LUO Chao-ying XIE Jia-sheng LI Jin-yu ZHENG Ji-fang 《中国畜牧兽医》2014,41(5):208-210
The assay was aimed to investigate the effects of Zhike Pingchuan granules on expectorant, antitussive and antiasthmatic by animals experiment.Capillary method was used to observe the expectorant effect in rat,the cough model induced by strong ammonia in mice was used to observe the antitussive effect,asthma model induced by spraying method was used to observe the antiasthmatic effect.The results showed that the low dosage group of Zhike Pingchuan granules significantly increased excretion of trachea quantity compared with the blank control group (P＜0.05),and there were extremely significant differences between the blank control group and middle,high dosage groups (P＜0.01);the three high,middle and low dosage groups of Zhike Pingchuan granules extremely significantly prolonged the latent period of cough and decreased the frequency of cough induced by strong ammonia compared with the blank control group (P＜0.01); the low dosage group of Zhike Pingchuan granules had not significantly prolonged the latent period of asthma induced by 4% acetylcholine chloride compared with the blank control group (P＞0.05),and middle and high dosage groups had extremely significant difference compared with the blank control group (P＜0.01).Zhike Pingchuan granules had the effects of expectorant,antitussive and antiasthmatic. 相似文献
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