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胰岛素样生长因子(IGFs)在哺乳动物的生长发育过程中通过受体介导对生物体的生长起重要的调节作用。其在早期的胚胎发育过程中,对胚胎的生长发育十分重要。IGFs通过与IGFBPs家族蛋白的结合调节早期胚胎发育过程中的细胞凋亡。IGF-1可以增加体外培养的胚胎的囊胚发育率,并与其它基因协同作用调节胚胎细胞的凋亡,但其确切的抗凋亡的分子机理目前仍在研究中。 相似文献
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胎儿宫内发育迟缓(IUGR)会阻碍动物的生长发育,尤其是动物消化系统的生长发育。本文综述了胰岛素和胰岛素样生长因子(IGFs)对动物生长发育的影响,及二者与IUGR的关系,提出胰岛素和IGFs可能对IUGR的治疗有重要意义,具有良好的应用前景。 相似文献
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Cichlasoma dimerus responds to refeeding with a partial compensatory growth associated with an increment of the feed conversion efficiency and a rapid recovery of GH/IGFs axis 
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下载免费PDF全文 T.H. Delgadin I. Simó D.I. Pérez Sirkin M.P. Di Yorio S.E. Arranz P.G. Vissio 《Aquaculture Nutrition》2018,24(4):1234-1243
Many fish species display compensatory growth (CG), a phenomenon by which fasted fish grow faster during refeeding. However, most studies use a group‐housed fish approach that could be problematic in social fish when interaction between individuals is not considered or eliminated. Additionally, the growth hormone (GH)/insulin‐like growth factors’ (IGF‐1 and IGF‐2) axis is implicated in postnatal growth in vertebrates, but its relevance in CG is not fully understood. Thus, the aim of this work was to determine whether CG occurs in a social fish, Cichlasoma dimerus, using an individually held fish approach and secondly, to evaluate the GH/IGFs expression profile during refeeding by 3 days and 3 weeks. C. dimerus showed partial CG. The feed conversion efficiency (FCE) was higher in three‐day‐refed fish, which presented higher GH plasma and mRNA levels than controls but shown no differences in liver and muscle GH receptors (GHR1 and GHR2) and IGFs mRNA levels. Surprisingly, three‐week‐refed fish exhibited GHR1 and IGF‐2 increments, but a reduction in GHR2 expression in muscle. These results show a strong association between GH levels, growth rate and FCE during refeeding, and a long‐lasting effect of refeeding on muscular expression of GHRs and IGF‐2. 相似文献
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Kazushi Azuma Makoto Asakawa Toshiaki Konno Shoko Fukuda Midori Goto Asakawa 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2019,48(3):429-434
A 13‐year‐old spayed female Pomeranian dog was presented for persistent, severe hypoglycemia (37 mg/dL; reference interval [RI] 75‐128 mg/dL). Progressive nonregenerative anemia (hematocrit 23.3%‐15.9%; RI 37.0%‐55.0%) and severe thrombocytopenia (36 000/µL; RI 200‐500 000/µL) were also noted. The serum insulin concentration was low (0.24 ng/mL; RI 0.302‐1.277 ng/mL). Computed tomography revealed multiple splenic nodules (1‐6 mm in diameter) and several hepatic nodules (7.6, 12 mm in diameter). Ultrasound‐guided fine‐needle aspiration of the splenic and hepatic nodules revealed low numbers of epithelial cells with mild cellular atypia, suggestive of a metastatic epithelial tumor, but the primary site was unknown at that time. On careful oral examination under general anesthesia, an enlarged right tonsil was noted grossly, and histopathologic examination of the tonsil diagnosed squamous cell carcinoma. Bone marrow aspirates and biopsies of the splenic and hepatic nodules were performed; all samples were diagnosed as metastatic carcinoma on histopathologic examination. No nodules were present in the pancreas, despite careful palpation during exploratory laparotomy. On immunohistochemistry, the neoplastic cells were positive for cytokeratin AE1/3 and insulin‐like growth factor (IGF)‐I but were negative for chromogranin A, PGP9.5, insulin, and inconclusive for IGF‐II. This is the first report of a primary IGF‐I‐producing squamous cell carcinoma in the tonsil of a dog with metastases to bone marrow, liver, and spleen, resulting in hypoglycemia. 相似文献
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M.A. Avella 《Aquaculture (Amsterdam, Netherlands)》2007,273(1):87-95
At present, clownfishes are the best example of successfully captive bred ornamental specimens but little is known about the relationship between food enrichment and both larval growth and development. In fact, it is well known that a certain percentage of these fishes cultured in captive conditions show a miss-band pigmentation. In the present study, the effects of live prey enrichment on growth and pigmentation in false percula clownfish (Amphiprion ocellaris) larvae were tested.Newly hatched A. ocellaris larvae were divided in three different groups and fed as follows: group A fed on enriched (Algamac 2000) B. plicatilis (10 ind./mL) from day 1 to day 5 post-hatch (ph); group B fed on enriched (Algamac 2000) B. plicatilis (10 ind./mL) followed by Artemia nauplii (5 ind./mL;) and group C fed on Algamac 2000 enriched B. plicatilis and Algamac 2000 enriched Artemia nauplii.Samples of the larvae were collected on day 5 from group A and on day 11 ph in group B and C for morphometric and molecular analysis. On day 11 ph food enrichment resulted in a better growth of group C larvae respect to those of group B fed on not enriched Artemia nauplii (15.8 ± 0.2 mg and 8.78 ± 0.02 mm vs. 6.8 ± 0.2 mg and 6.93 ± 0.01 mm). Moreover, 36 ± 2% of the juveniles obtained from group B showed a miss-band pigmentation as compared to 29 ± 1% of the juveniles obtained from group C. At molecular level, the results obtained by Real-Time PCR are in agreement with the morphometric ones: a positive induction of the Insulin-like Growth Factor II (IGFII) and Peroxisome Proliferator Activated Receptor α and β (PPARα and PPARβ) gene expression and a reduction of Myostatin (MSTN) was observed in group C larvae fed on enriched live prey. IGFI gene expression was higher in group B.The present study provides clear evidences of the positive role of Algamac 2000 on growth and pigmentation of captive cultured false percula clownfish. 相似文献
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机体的生长激素(GH)/类胰岛素样生长因子(IGFs)轴由GH系统和IGFs系统构成,可促进细胞增殖、调节生长发育、调控生理代谢,在机体生长发育调控方面有着重要作用。为明确棘腹蛙GH/IGFs轴的功能结构和进化特征,为棘腹蛙生长发育调控方面的研究提供理论依据,本试验对棘腹蛙GH、类胰岛素生长因子-Ⅰ(IGF-Ⅰ)和类胰岛素生长因子-Ⅱ(IGF-Ⅱ)进行克隆并对其序列特征进行分析。结果显示:1)与两栖类模式动物的多重序列比对发现,棘腹蛙GH、IGF-Ⅰ和IGF-Ⅱ的功能结构域严格保守,具有一定的遗传多态性;IGF-Ⅱ的N端呈简缩进化趋势。2)遗传进化聚类分析发现,棘腹蛙IGFs与两栖动物聚为一支,并与硬骨鱼相对近缘,说明IGF-Ⅰ和IGF-Ⅱ进化地位相对原始;棘腹蛙GH则与蛙类、鱼类等水生动物相对近缘,暗示该基因具有趋同进化趋势。3)为进一步明确上述基因的特异性功能位点,利用Swiss-model server软件解析其蛋白质结构,最终确定IGF-Ⅰ的THR52、LEU53、PHE72、PHE73、SER74为潜在的功能分化位点,IGF-Ⅱ的TYR81、LYS82、LYS83为潜在的功能分化位点,GH的PHE208为潜在的功能分化位点。由此可知,棘腹蛙GH/IGFs轴的主要基因相对保守,但与已知模式物种相比,存在潜在的功能分化位点,可作为后期棘腹蛙GH/IGF轴功能研究和遗传进化特征分析的分子靶标。 相似文献
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