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排序方式: 共有136条查询结果,搜索用时 326 毫秒
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Since the first publication on “regional ileitis”, the relevance of this chronic inflammatory disease condition termed finally as Crohn's disease is continuously increasing. Although we are beginning to comprehend certain aspects of its pathogenesis, many facets remain unexplored. Host's gut microbiota is involved in a wide range of physiological and pathological processes including immune system development, and pathogen regulation. Further, the microbiome is thought to play a key role in Crohn's disease. The presence of Crohn's-associated variants of NOD2 and ATG16L genes appears to be associated not only with alterations of mucosal barrier functions, and bacterial killing, but the gut microbiota, as well, reflecting a potential relationship between the host's genotype and intestinal dysbiosis, involved in disease etiology. This review aims to characterize some exciting new aspect of Crohn's disease pathology, focusing mainly on the role of intestinal microbes, and their interplay with the immune system of the host. 相似文献
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Buchanan JW Patterson DF 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2003,17(2):167-171
Patent ductus arteriosus (PDA) is the most common congenital heart disease in dogs and usually causes heart failure and death unless corrected at a young age. Previous histologic studies in a line of dogs derived from Miniature Poodles with hereditary PDA identified varying degrees of hypoplasia and asymmetry of ductus-specific smooth muscle and the presence of aortalike elastic tissue in the ductus wall sufficient to cause patency. To determine if similar structural abnormalities cause PDA in other dogs, serial-section, 3-dimensional histology of ductal architecture was studied in 8 non-Poodle purebred dogs with PDA with no immediate family history of PDA. Morphologic abnormalities were observed in 7 of 8 dogs with PDA and essentially were the same as those in dogs known to have a hereditary form of PDA. These findings suggest that apparently sporadic PDA in these breeds is caused by a genetic defect in the structure of the ductus arteriosus that is similar or identical to that in the Poodle. The relatives of dogs with PDA, particularly parents, offspring, and siblings, should be screened for evidence of PDA. Dogs with PDA should not be used for breeding, regardless of breed. 相似文献
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Gookin JL Nordone SK Argenzio RA 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2002,16(1):12-21
Cryptosporidium is a clinically and economically important infection whose pathogenic effect begins with colonization of the intestinal epithelium. Despite intensive efforts, a consistently effective therapy for the infection has yet to be identified. Morbidity and mortality results from ongoing loss of absorptive epithelium, which leads to villous atrophy and malabsorption and release of inflammatory mediators that stimulate electrolyte secretion and diarrhea. With further clarification of the mechanisms underlying enterocyte malfunction in Cryptosporidium infection, it should be possible to design rational nutritional and pharmacologic therapies to enhance nutrient and water absorption, promote the clearance of infected enterocytes, and restore normal villus architecture and mucosal barrier function. 相似文献
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南京毛刺线虫对山定子的直接致病性研究 总被引:2,自引:0,他引:2
北京南口农场山定子砧苹果树受线虫侵害严重。田间树势调查结果表明:病树长势衰退,产量降低,品质下降;补植的幼树表现出再植病症状。田间根系症状调查结果表明:病树根系生长异常,表现出典型的短粗根病症状,即受害幼根不呈延伸生长,而是在生长中不断分枝,以致最后形成须状丛簇根,每年只在新根旺长期长出一小段具有吸收功能的白色、毛笔尖状的新根。盆栽幼苗接种试验表明:南京毛刺线虫的侵染严重影响了山定子幼苗的形态建成,且使根系表现出短粗根病症状,从而证明南京毛刺线虫(Trichodorus nanjingensis Liu&Chen)是导致该场苹果树势衰退、再植病和短粗根病的主要病原。 相似文献
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In order to characterize foot-and-mouth disease virus (FMDV) infection dynamics in pigs, two simulated-natural inoculation systems were developed and evaluated. Intra-oropharyngeal (IOP) and intra-nasopharyngeal (INP) inoculation both enabled precise control of dose and timing of inoculation while simulating field exposure conditions. 相似文献
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锦鲤暴发性出血症病原的研究 总被引:6,自引:0,他引:6
从患暴发性出症的锦鲤体内分离出2株细菌-052202和052203,应用细菌分离鉴定方法和法国Biomerieux FRC公司的API全自动微生物鉴定系统进行鉴定,结果显示:052202株为嗜麦芽窄食单胞菌(Stenotrophomonas maltophilia),052203株为温和气单胞(菌(Aeromonas sobria)。生物毒性试验的结果表明,温和气单胞菌可使健康锦鲤死亡,引起体表出血,肝,肾,脾,胆囊发生病变,有致病性;而嗜麦芽窄食单胞菌不引起健康锦鲤死亡,无致病性,28例药物的药敏试验结果表明,温和气单胞菌对新霉素,卡那霉素,庆大霉素,头孢噻吩,头孢曲松的头孢他啶的敏感性强或较强。 相似文献
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鸡贫血因子病的血液病理学变化 总被引:1,自引:0,他引:1
本实验用鸡贫血病毒感染1日龄健康AA雏鸡,以未感染雏鸡为对照,在感染后7、14、28、35、42日龄检测其外周血液各种血细胞数量,血红蛋白含量,红细胞压积,红细胞平均体积,红细胞平均血红蛋白量、红细胞平均血红蛋白浓度;骨髓红系祖细胞、粒单系祖细胞(CUF-GM)、基质成纤维祖细胞(CFU-F)的增殖功能;血清因子和胞腺集落刺激因子(CSF)对造血祖细胞增殖功能的影响;骨髓造血细胞分化功能;骨髓造血 相似文献
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