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The expression pattern of TIR8 is conserved among vertebrates 总被引：1，自引：0，他引：1
Federica Riva Nadia Polentarutti Giulia Tribbioli Alberto Mantovani Cecilia Garlanda Lauretta Turin 《Veterinary immunology and immunopathology》2009,131(1-2):44-49
IL-1R/TLRs play an important role in the inflammatory responses. Their signaling pathway is tightly regulated to keep inflammation under control. The regulation involves both extracellular and intracellular mechanisms. TIR8, also known as SIGIRR (Single Immunoglobulin IL-1R-Related molecule), is an orphan receptor belonging to the IL-1R/TLRs super-family. Recent studies suggest its role in modulating the inflammatory response in the gastrointestinal tract in mice, acting as an IL-1 receptor family antagonist. We identified the sequence and analyzed the expression of TIR8 in a wide panel of organs and tissues in different animals. There was high homology of the cDNA sequence among human, mouse and the domestic species (74–85%). The pattern of expression of this receptor was similar in all the species examined (high levels in kidney and gastrointestinal tract) and similar to the human. These results demonstrate that TIR8 is conserved, in evolutionary terms, both with regard to sequence and pattern of expression, a finding consistent with a key function of this molecule in modulating inflammation in the gastrointestinal tract. 相似文献
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IL-1R8 is a member of Interleukin-1 receptor family acting as a negative regulator of inflammation reliant on ILRs and TLRs activation. IL-1R8 role has never been evaluated in acute bacterial mastitis. We first investigated IL-1R8 sequence conservation among different species and its pattern of expression in a wide panel of organs from healthy goats. Then, modulation of IL-1R8 during natural and experimental mammary infection was evaluated and compared in blood, milk and mammary tissues from healthy and Staphylococcus aureus infected goats. IL-1R8 has a highly conserved sequence among vertebrates. Goat IL-1R8 was ubiquitously expressed in epithelial and lymphoid tissues with highest levels in pancreas. IL-1R8 was down-regulated in epithelial mammary cells following S. aureus infection. Interestingly it was up-regulated in leukocytes infiltrating the infected mammary tissues suggesting that it could represent a target of S. aureus immune evasion. 相似文献
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ZHOU Qiu-ge LIU Chang LIU Yu-hui LAI Jin-lun CHEN Ying-yu GUO Ai-zhen HU Chang-min 《中国畜牧兽医》2016,43(10):2640-2647
Single immunoglobulin IL-1 related receptor (SIGIRR) is a member of TIR superfamily.Recent evidences suggested that it could negatively modulate ILRs/TLRs-mediated innate immune response,and in particular its important role focused from infectious and intestinal inflammation to autoimmunity or cancer-related inflammation had been illuminated.Here,we summarized our current understanding of the expression patterns of SIGIRR gene and protein in different specises including human,mouse and bovine,its downregulate function of the IL-1/TLRs singal pathway and specific negative regulation mechanism ascribed to its structure specificity,and also its elaborate regulating process related to the occurrence and development of different pathogen condition.And then it can not only provide theoretical references for clinical inflammatory related disease,but also broaden the application scope of SIGIRR gene in the treatment of animal diseases. 相似文献
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单免疫球蛋白白介素1受体相关蛋白（SIGIRR）是TIR超家族成员,最新研究表明它可负性调节IL-1R/TLRs受体介导的固有免疫应答,且在感染性疾病、肿瘤及自体免疫病诱导的炎症反应调节上所起的重要作用已经被阐明。作者主要综述了SIGIRR基因和蛋白表达模式在人、小鼠、牛等物种间的差异性,因其结构特异性所具有的对IL-1R/TLRs炎性信号通路的负性调控和具体的调控机理,以及在不同炎性相关疾病的发生和发展中抑制炎性反应的机制,进而为临床的炎性相关疾病治疗提供理论借鉴,同时也拓宽了SIGIRR基因在动物疾病治疗中的应用范围。 相似文献
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