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The capacity for locomotion and for chemotaxis is probably very different in monocytes and macrophages from different sources. Numerous techniques have been established for studying the locomotion of these cells. Many of the factors are sparsely documented and the reports are scattered among various cell types. Heterogeneity of locomotion and chemotactic responsiveness is evident when established macrophage lines and mouse peritoneal macrophage are studied. The effects of mononuclear phagocytes and their released products on the locomotion of other cell types are reviewed. 相似文献
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H Blobel J Brückler D Kitzrow W Schaeg 《Comparative immunology, microbiology and infectious diseases》1980,3(4):447-453
Several staphylococcal substances could interfere with phagocytosis, imparting a definite advantage on Staphylococcus aureus in the initial phase of infection. Leukocidins were shown to damage mainly granulocytes and macrophages. Clumping-factor, by direct reaction with fibrinogen, induced clumping of the staphylococci in plasma. This impaired phagocytosis. The increased virulence of encapsulated staphylococci was caused by a delay in chemotaxis and phagocytosis. Apparently encapsulation prevented activation of C3, by the staphylococci. 相似文献
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H Hayashi T Yoshimura J Y Chen 《Comparative immunology, microbiology and infectious diseases》1985,8(2):73-87
Our particular attention in this article was given to natural mediators for macrophages isolated from the sites of tissue injury. A number of chemotactic factors, which may satisfy many criteria making them acceptable as inflammatory leucocyte chemotactic factors, has been separated. Among them, our laboratory has isolated three macrophage (monocyte) chemotactic factors (MCF-a, -b and -c). Their purification, characterization and functional specificity are discussed. 相似文献
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