| 微生物-肠-肌轴调节骨骼肌代谢和功能的研究进展 |
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| 引用本文： | 周敏,汪凯歌,张濂,马曦.微生物-肠-肌轴调节骨骼肌代谢和功能的研究进展[J].畜牧兽医学报,2022,53(9):2845-2857. |
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| 作者姓名： | 周敏 汪凯歌 张濂 马曦 |
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| 作者单位： | 1. 中国农业大学动物科技学院, 北京 100193;2. 河南科技学院动物科技学院, 新乡 453003 |
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| 基金项目： | 国家自然科学基金（31930106）；中国农业大学2115人才发展计划（1041-0010919）；河南省重大公益专项（201300111200-05） |
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| 摘 要： | 骨骼肌的质量不仅影响着人或动物机体的运动能力和健康状态，还影响着畜禽的肌肉产量和品质。随着对微生物功能的深度挖掘，肠-脑轴、肠-肝轴、肠-脂轴等由微生物及其代谢产物介导的信号途径均被证实参与了机体的能量代谢。近年来，微生物-肠道-骨骼肌轴也被证实，因此通过调控肠道菌群或其代谢产物进而调节机体骨骼肌代谢为改善肌肉产量和品质提供了新的思路。本文主要综述了肠道微生物及其关键代谢产物在骨骼肌功能和糖脂代谢等方面的潜在作用和机制，并简要总结了菌群介导的调控骨骼肌功能的潜在手段，为畜禽养殖中改善肉质提供了一定的参考和新思路。
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| 关 键 词： | 微生物 骨骼肌 糖脂代谢 益生菌 运动 |
| 收稿时间： | 2021-12-21 |
Advances in Microbiota-Gut-Muscle Axis Regulating Skeletal Muscle Metabolism and Function |
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| ZHOU Min,WANG Kaige,ZHANG Lian,MA Xi.Advances in Microbiota-Gut-Muscle Axis Regulating Skeletal Muscle Metabolism and Function[J].Acta Veterinaria et Zootechnica Sinica,2022,53(9):2845-2857. |
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| Authors: | ZHOU Min WANG Kaige ZHANG Lian MA Xi |
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| Institution: | 1. College of Animal Science and Technology, China Agricultural University, Beijing 100193, China;2. College of Animal Science and Technology, Henan Institute of Science and Technology, Xinxiang 453003, China |
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| Abstract: | The quality of skeletal muscle not only affects the exercise ability and health state of human or animal, but also affects the production and quality of muscle in livestock and poultry. With the in-depth exploration of microbial functions, gut-brain axis, gut-liver axis, gut-lipid axis and other signaling pathways mediated by microorganisms and their metabolites have been confirmed to participate in the body's energy metabolism. In recent years, microbiota-gut-muscle axis has also been confirmed. Therefore, regulating the metabolism of skeletal muscle by regulating intestinal flora or its metabolites provides a novel insight to improve muscle production and quality. This review mainly summarizes the potential role and preliminary mechanism of intestinal microorganisms and their key metabolites in skeletal muscle function and glucose and lipid metabolism, and briefly summarizes the potential means of regulating flora to control skeletal muscle function, which provides a certain theoretical reference and new ideas for improving meat quality in animal husbandry production. |
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| Keywords: | microorganism skeletal muscle glucose and lipid metabolism probiotics exercise |
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