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妊娠后期日粮中添加不同水平N-氨甲酰谷氨酸对母猪繁殖性能的影响 总被引：1，自引：0，他引：1
本试验研究了日粮中添加不同水平N-氨甲酰谷氨酸(N-carbamylglutamate,NCG)对妊娠后期母猪繁殖性能的影响,并对其作用机理进行初步探讨.选用妊娠80 d的长大母猪32头,随机分成4组(对照组和试验组1、2、3),每组8个重复.对照组饲喂基础日粮,试验组在基础日粮中分别添加0.04％、0.08％、0.12％ NCG.母猪妊娠第110天采血分离血浆用于测定血浆游离氨基酸、NO、NOS、激素含量和血液生化指标.结果表明,母猪妊娠后期日粮中添加0.08％NCG比空白对照组窝产活仔数提高11.75％(10.75 vs.9.62,0.05＜P＜0.1),窝产活仔总质量提高13.23％(16.52 kg vs.14.59 kg,P＜0.05),窝产死胎数降低57.14％(0.75 vs.1.75,P＜0.05),降低了血浆尿素氮含量(P＜0.05),同时提高了血浆精氨酸、NO、生长激素、锌离子浓度(P＜0.05).日粮中添加0.04％和0.12％ NCG也改善了母猪部分繁殖性能.上述结果表明,母猪妊娠后期日粮中添加NCG提高了母猪的繁殖性能,其作用机制可能是NCG有效提高了母猪内源精氨酸的合成,改善了母猪子宫内环境和胎猪营养供给,保证了胎猪的存活和生长. 相似文献
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《养殖与饲料．饲料世界》2021,(10)
N-氨甲酰谷氨酸(NCG)是N-乙酰谷氨酸的结构类似物,具有促进哺乳动物内源性精氨酸合成的作用。NCG以饲料添加剂的形式应用于农业生产中。最初发现NCG具有提高哺乳动物繁殖性能的作用,随着研究的深入,发现NCG还可以提高畜禽的生产性能、缓解氧化应激反应和炎症反应的作用。本文论述了NCG在畜禽养殖中的研究进展,为畜禽业使用NCG提供了参考依据。 相似文献
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精氨酸及其替代物改善母猪繁殖性能的营养调控机制与应用技术 总被引：1，自引：1，他引：0
文章综述了改善母猪繁殖性能的特殊营养调控剂精氨酸及其替代物——N-氨甲酰谷氨酸的营养调控功能及其机制,特别阐明了NCG替代Arg在生产中的应用优势,对改善繁殖母猪生产性能具有重要的指导意义。 相似文献
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《中国饲料》2017,(9)
本试验旨在研究妊娠后期及泌乳期日粮中添加N-氨甲酰谷氨酸(NCG)对经产母猪繁殖性能、血浆部分氨基酸水平及哺乳仔猪生长性能的影响。选取34头二元杂交母猪(5~6胎),随机分成2组,每组17头,每头母猪为1个重复。从母猪妊娠85 d开始分别饲喂基础日粮(对照组)和0.05%NCG日粮(NCG组)至产后第21天(仔猪断奶),试验期共50 d。结果显示:与对照组相比,NCG组仔猪初生活仔重和初生窝重分别提高11.11%和30.12%(P0.05);NCG组母猪窝总产仔数、窝产活仔数较对照组分别提高了0.84、1.54头,NCG组死胎率和弱仔率较对照组分别降低了36.31%和37.29%,但差异均不显著(P0.05);健仔率和母猪泌乳量分别提高了10.06%和2.70 kg/d(P0.05);NCG组母猪妊娠第110天血浆精氨酸、脯氨酸和鸟氨酸浓度均显著提高了21.66%、44.77%和23.04%(P0.05);NCG组仔猪日增重、断奶个体重和断奶窝重均显著提高了12.18%、11.95%和31.10%(P0.05),仔猪断奶后发病率显著降低了29.79%(P0.05)。综上所述,妊娠后期和泌乳期添加0.05%NCG可以提高经产母猪繁殖性能、血浆部分氨基酸水平和哺乳仔猪的生长性能。 相似文献
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本试验旨在研究妊娠早期饲粮中添加N-氨甲酰谷氨酸（NCG）对母羊胚胎存活及相关血液指标的影响,并对其作用机制进行初步探讨。选择发情正常、健康状况良好的湖羊50只,随机分为2组（对照组和NCG试验组）,每组25只母羊,自配种当天开始给母羊分别饲喂基础饲粮（对照组）和基础饲粮+0.11%NCG（NCG组）,饲喂期38 d。测定妊娠第19和38天母羊血浆游离氨基酸、总一氧化氮合酶（TNOS）、内皮型一氧化氮合酶（eNOS）、诱导型一氧化氮合酶（iNOS）、一氧化氮（NO）、雌二醇、孕酮的浓度;38 d时每组各屠宰7只妊娠母羊,测定妊娠母羊的黄体数和活胎儿数等指标。结果显示,与对照组相比,妊娠第38天时,NCG组每只母羊总胎儿数增加了79.72%（P<0.05）,活胎儿数增加了79.72%（P<0.05）,胎儿形成指数增加了0.26（P<0.05）,胎水体积增加了72.89%（P<0.05）,活胎儿总重提高了71.13% （P<0.05）;NCG组妊娠第19天的甘氨酸、蛋氨酸、赖氨酸、精氨酸、NO、iNOS、eNOS和孕酮的浓度显著高于对照组（P<0.05）,NCG组妊娠第19天的瓜氨酸和脯氨酸极显著高于对照组（P<0.01）;NCG组妊娠第38天的精氨酸、脯氨酸和NO显著高于对照组（P<0.05）,NCG组妊娠第38天的iNOS和eNOS的浓度极显著高于对照组（P<0.01）。由此,妊娠早期饲粮中添加NCG提高了胚胎和胎儿的存活,增加了妊娠母羊第38天的总胎儿数和活胎儿数,改善了母羊的繁殖性能,其作用机制可能是NCG促进了母羊内源性精氨酸的合成,提高了母羊血浆精氨酸、NO和孕酮含量,改善了子宫内环境和营养供给,使之有利于胚胎着床和妊娠维持。 相似文献
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Arginine (ARG) exerts many beneficial effects on animal body and enhanced angiogenesis, lactogenesis, which finally leads to the improvement in nitrogen (N) metabolism, reproduction, lactation, immunity and growth. Unfortunately, unprotected ARG will be degraded in the rumen and its price is high, thus feeding rumen-protected ARG seems to be uneconomical. Alternatively, N-carbamoyl glutamate (NCG) is structural analogue of N-acetyl glutamate, cofactor of cabamoyl phosphate synthetase1, is lower in rumen degradation compared to ARG. Additionally, rumen epithelial and duodenal cells have potentially utilized the NCG for ureagenesis. Supplementation of NCG to high yielding dairy cows increased plasma concentration of ARG and nitric oxide, decreased the plasma ammonia N and improved lactation performance and N utilization. Supplementation of NCG enhanced pregnancy rates in rats, improved litter size and fetal survival rate, thereby improved the reproductive performance of sows. Oral NCG supplementation increases plasma ARG and somatotropin levels, and increased growth rate and muscle protein synthesis in nursing piglets. The NCG is potential a relatively cheaper source of feed additive to offer vital compensation over oral administration of ARG, resulting in improved ruminant animal health and production. In this article, we reviewed the mechanism of ARG biosynthesis by NCG and their significance in growth, reproduction, milk production and N utilization in ruminant animals. 相似文献
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《畜牧与生物技术杂志(英文版)》2018,(4)
Background: High-altitude pulmonary hypertension(HAPH) is a life-threating condition for animals in high altitude,and disturbance of endothelial nitric oxide(NO) synthesis contributes to its pathogenesis. N-carbamylglutamate(NCG), which enhances arginine synthesis, promotes endogenous synthesis of NO. In this study, we determined the effects of NCG on alleviating HAPH in Holstein heifers that ascended to Tibet(Lhasa, 3,658 m).Methods: Exp. 1, 2,000 Holstein heifers were transported from low elevation(1,027 m) to Lhasa. After being exposed to hypoxia for 1 yr, Holstein heifers were assigned to a healthy group(Control, n = 6) with mean pulmonary hypertension(mPAP) 41 mmHg, and an HAPH affected group(HAPH, n = 6) with mPAP 49 mmHg.Lung tissues were collected to evaluate histopathological changes and the expression of endothelial nitric oxide synthase(eNOS). Exp. 2, ten healthy heifers and 10 HAPH affected heifers were supplemented with NCG(20 g/d per heifer) for 4 wk. Physiological parameters were determined and blood samples were collected on d-1 and d 28 of the feeding trial.Results: Expression of e NOS in small pulmonary arteriole intima was higher in the healthy than HAPH group(P = 0.006), whereas HAPH group had significantly thicker media and adventitia than healthy group(all P 0.05). The mRNA of eNOS and protein level of eNOS were higher in the lungs of heifers in the healthy group than in the HAPH group(both P 0.001), whereas endothelin-1 protein levels were higher in HAPH group than in the healthy group(P = 0.025). NCG supplementation decreased mPAP and ammonia(both P = 0.001), whereas it increased the expression of eNOS, arginine, and plasma NO(all P 0.05).Conclusions: The expression of eNOS was decreased in Holstein heifers with HAPH. NCG supplementation decreased m PAP through the restoration of eNOS and endogenous NO synthesis. 相似文献
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TANG Zhi-qun ZHOU Jia-dong HONG Wei-ming CAO Fei ZUO Wei-yong ZHU Shan-yuan 《中国畜牧兽医》2015,42(5):1130-1136
This study was conducted to investigate the effects of N-carbamylglutamate (NCG) and arginine (Arg) on growth performance, serum biochemical indexes and serum free amino acid content of Jinghai Yellow broiler chicks.A total of 600 1-day-old chicks with similar weight were used and randomly assigned into 5 groups with 6 replicates per group and 20 chicks per replicate.The control group was fed with basal diet, groups Ⅰ to Ⅳ were fed with the basal diets supplemented with 0.05%, 0.10%, 0.15% NCG and 0.10% Arg, respectively.The trial lasted for 28 days.The results showed that compared with control group, the supplementation of 0.05%, 0.10%, 0.15% NCG and 0.10% Arg increased ADG, the supplementation of 0.10% NCG significantly decreased F/G (P<0.05).The supplementation of 0.10% NCG significantly decreased the contents of AMM, UA and LDL in serum compared with other groups (P<0.05), the supplementation of 0.15% NCG significantly increased the contents of NO, NOS and ALP in serum compared with control group (P<0.05).Compared with control group, the supplementation of 0.10%, 0.15% NCG and 0.10% Arg significantly increased the content of Arg in serum (P<0.05).These results indicated that supplementation with NCG could increase the contents of Arg and Pro in serum, improve blood parameters and growth performance of broiler chicks, and the appropriate supplemental level of NGG was 0.10%. 相似文献
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本试验旨在探讨N-氨甲酰谷氨酸(N-carbamylglutamate,NCG)和精氨酸(Arg)对京海黄鸡肉仔鸡生长性能、血清生化参数及游离氨基酸含量的影响。选用1日龄体重相近的京海黄鸡肉仔鸡600只,随机分为5组,每组6个重复,每个重复20只。对照组饲喂基础日粮,试验Ⅰ、Ⅱ、Ⅲ、Ⅳ组饲喂在基础日粮中分别添加0.05%、0.10%、0.15% NCG及0.10% Arg的试验日粮。试验期28 d。结果表明,与对照组相比,添加0.05%、0.10%、0.15% NCG及0.10% Arg组平均日增重(ADG)升高,添加0.10% NCG组料重比(F/G)显著降低(P<0.05);添加0.10% NCG组血清中血氨(AMM)、尿酸(UA)和低密度脂蛋白(LDL)含量相对于其他各组显著降低(P<0.05),添加0.15% NCG组血清中一氧化氮(NO)、一氧化氮合成酶(NOS)和碱性磷酸酶(ALP)含量显著高于对照组(P<0.05);与对照组相比,添加0.10%、0.15% NCG组和添加0.10% Arg组血清中Arg含量显著升高(P<0.05)。综上所述,日粮中添加NCG有助于提高京海黄鸡肉仔鸡血清中Arg和脯氨酸(Pro)的含量,改善血液指标,提高肉仔鸡的生长性能,其中NCG添加水平为0.10%时效果较好。 相似文献
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B Zhang LQ Che Y Lin Y Zhuo ZF Fang SY Xu J Song YS Wang Y Liu P Wang D Wu 《Reproduction in domestic animals》2014,49(5):740-745
The effect of dietary N‐carbamylglutamate (NCG) supplementation during the entire gestation on reproductive performance of gilts was determined. At the initial day of gestation, forty‐five cross‐bred (Landrace × Large white) gilts were randomly assigned to five groups receiving a basal diet (control group) and basal diet supplemented with 0.05%, 0.10%, 0.15% and 0.20% NCG until parturition, respectively. At parturition, total litter size, live litter size and rate of stillbirth were not markedly affected by NCG supplementation. However, gilts in 0.05% NCG‐supplemented group had more pigs born alive than gilts in control group (+1.11 pigs, p = 0.12), and live litter weight was increased (+12.13–19.17%, p < 0.05) in 0.05%, 0.10% and 0.15% NCG‐supplemented groups relative to control group. And also, average birthweight of piglets born alive was higher (+6.57%, p < 0.05) in 0.05% NCG‐supplemented group than in control group. Furthermore, on days 30, 60, 90 and 110 of gestation, concentrations of arginine and ornithine in plasma were higher (p < 0.05) in 0.05%, 0.10%, 0.15% and 0.20% NCG‐supplemented groups than in control group, respectively. In addition, the chorioallantois gene expression of endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor A (VEGF‐A), placental growth factor (PLGF) and angiopoietin‐2 (ANG‐2) was all increased (p < 0.05) in 0.05%, 0.10% and 0.15% NCG‐supplemented groups than in control group. In conclusion, dietary supplementation with 500 mg/kg NCG during the entire gestation significantly improves pregnancy outcomes in gilts, which may be associated with the improved concentrations of arginine in plasma and placental angiogenic factors gene expression of gilts. 相似文献
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