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卢建明 《国外畜牧学(猪与禽)》1998,(1):41-42
三十多年前一位家禽专家首次提及产蛋母鸡表现为肝脏脂肪变性的一种代谢疾病。由于这一病症具有极大的经济意义，自从那时以来，人们经常提到这一所谓的脂肪肝综合征。 相似文献
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长链非编码RNA（lncRNA）在许多生物学过程中发挥着重要的调节作用。河南农业大学家禽种质资源创新工程研究中心通过对产蛋前期（20周龄）和产蛋高峰期（30周龄）卢氏绿壳蛋母鸡肝脏组织的转录组分析,筛选出了一个在产蛋高峰期母鸡肝脏中表达水平显著上调的lncRNA（lncLER）。本研究利用半定量PCR（RT-PCR）、实时荧光定量PCR分析了lncLER在卢氏绿壳蛋母鸡不同发育时期和不同组织中的表达规律,并从个体和细胞水平研究了体内、体外雌激素处理对lncLER表达的影响。结果表明,lncLER在卢氏绿壳蛋母鸡各组织中均有不同程度的表达,且在产蛋高峰期肝脏中的表达量较高;雌激素在个体和细胞水平可显著上调lncLER的表达。本试验初步阐明了lncLER基因在卢氏绿壳蛋母鸡中的表达调控规律,为进一步研究lncLER在鸡产蛋过程中的生物学功能奠定了基础。 相似文献
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鸡脂肪肝综合症又叫脂肪肝出血综合征,常发于产蛋母鸡的产蛋高峰期,是本县常见的一种慢性、营养代谢性疾病,尤其是笼养蛋鸡群,多数情况是鸡体况良好,发病初期并无临床表现,随着脂肪在肝脏中的不断聚集,随后才逐步表现出临床症状,如果未及时发现,会出现大面积死亡。死亡鸡腹腔及皮下大量脂肪蓄积,肝被膜下有血凝块为特征。公鸡极少发生。 相似文献
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本试验选用正在产蛋和休产的来航鸡,用放射配体结合分析法,分别测定两组鸡的肝脏和输卵管胞浆和胞核受体含量。胞浆液的蛋白含量用考马斯亮蓝G250法测定;胞核DNA含量用紫外吸收法测定。试验结果表明:两组鸡的肝脏和输卵管的胞浆雌激素受体含量均无明显差异;两组鸡的肝脏和输卵管的胞核雌激素受体含量,产蛋鸡肝脏的胞核雌激素受体是休产鸡的15倍,差异显著(P<0.05),而输卵管的胞核雌激素受体差异不明显。 相似文献
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脂肪肝综合征是指脂肪代谢发生障碍的一种营养代谢性疾病,以肝脏积累大量的脂肪、出现肝脏脂肪变性、使肝细胞与血管壁变脆而发生肝出血为主要特征。脂肪肝综合征多发生于产蛋母鸡中,尤其发生在笼养的产蛋高峰期的母鸡中。现将本省海安养鸡专业户的鸡发生本病的诊治情况报道如下。一.发病情况及临诊症状2003年7月中旬,海安大公镇一养鸡专业户所饲养的一批2500只的罗曼蛋鸡,饲养到达220日龄时,产蛋率达到92%,不久有下降的趋势,之后每天都有2～3只死亡,多发生在夜间。到240日龄时,产蛋率下降到70%以下,20天累计死亡40多只。该养鸡户以为是天气… 相似文献
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鸡脂肪肝综合症又称脂肝病,是鸡体内脂肪代谢障碍,大量脂肪沉积于肝脏,导致肝脏脂肪变性的一种疾病。主要发生于笼养产蛋母鸡和某些品种的肉用仔鸡。产蛋鸡患病后引起产蛋下降,死亡率升高,给养鸡户造成很大损失。由于本病早期临床症状不明显,很容易被忽视。现将笔者遇到的一起产蛋鸡脂肪肝综合征的诊疗情况介绍如下。 相似文献
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蛋鸡脂肪肝出血综合征的病因研究进展 总被引：1，自引：0，他引：1
蛋鸡脂肪肝出血综合征(FLHS)是一种代谢性疾病,营养、内分泌、遗传和环境等因素都可影响其发生。日粮中能量过高或蛋白不足是诱发FLHS的主要因素,能量、蛋白来源也影响FLHS的发生。日粮中脂肪酸来源影响FLHS的发生,动物性脂肪较易引起FLHS,适量添加植物油可降低肝脏脂肪含量。雌激素水平升高可引起肝脏脂肪含量增加,与FLHS存在一定的量效关系。甲状腺素和孕酮可降低肝脏脂肪含量,防止出血发生。FLHS易感品系UCD-3蛋鸡肯定了遗传因素对该病的影响。空间不充足或必要活动受限制,导致能量过剩是FLHS发生的重要诱因。肝脏脂肪沉积并不总是引起肝脏出血,脂质过氧化物分解生成大量脂质自由基引起细胞损伤,可能是肝脏脂肪含量升高导致出血的分子机制。 相似文献
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Ten laying hens with low plasma cholesterol levels and no signs of fatty liver syndrome were examined at necropsy. Liver coloration and deposition of body fat were not abnormal in such hens. Eleven nonlaying hens had signs of fatty liver syndrome. They were out of production for 1 to 3 months and had elevate plasma cholesterol levels. At necropsy, such hens had yellow livers, heavy deposits of body fat, and several involuted egg yolks, which were dark yellow. Intimal plaques were observed by light microscopy in the abdominal aortas of hens with low plasma cholesterol levels; the plaques contained little or no lipid and were composed of three or four rows of modified smooth-muscle cells. Aortic intimal plaques of hens with high plasma cholesterol levels were composed of 16 to 18 rows of modified smooth-muscle cells when examined by light microscopy. The plaques contained intracellular and extracellular lipid, indicating aortic atherosclerosis. Electron-microscopic observations of the abdominal aortas of both groups of hens were similar to light-microscopic observations, except that lipid, including cholesterol clefts, was seen both intracellularly and extracellularly in the thickened tunica intima of hens with high plasma cholesterol values. Thus, the presence of aortic atherosclerosis was confirmed by electron microscopy. It is suggested that the endogenous hypercholesterolemia and cessation of egg production, characteristic of severe fatty liver syndrome, originated from the reabsorption of involuted egg yolks and that such reabsorption caused the development of aortic atherosclerosis and deposition of excess body fat. 相似文献
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选用300日龄健康海蓝褐蛋鸡90羽,随机分为对照组、病理组、防治组3组（每组3个重复,每个重复10只）,分别饲喂正常日粮（代谢能11.30MJ/kg,粗蛋白质17.00%）、高能量低蛋白质日粮（代谢能12.81MJ/kg,粗蛋白质12.90%）和添加0.3mg/kg生物素的高能量低蛋白质日粮,试验期60d,分别于试验的1,30,60d,每组选取体质量相近的试验蛋鸡6羽,采血制备血清和采集肝脏样品及腹脂,测定血脂含量、肝脂率和腹脂率,观察其病理学变化。结果表明,与对照组相比,试验30,60d,高能量低蛋白质日粮组鸡产蛋性能、HDL-C含量显著降低,TG、TC、LDL-C、ALT、AST、肝脂率和腹脂率显著升高,肝脂肪变性明显。试验30d,与对照组比较,防治组鸡产蛋性能、HDL-C、TG、TC、LDL-C、ALT、AST、肝脂率和腹脂率差异不显著,肝脏脂肪变性不明显;与高能量低蛋白质日粮组比较,防治组鸡产蛋性能、HDL-C含量显著升高,TG、TC、LDL-C、ALT、AST、肝脂率和腹脂率显著降低。60d时,与对照组相比,防治组鸡产蛋性能、HDL-C显著降低,TG、TC、LDL-C、ALT、AST、肝脂率和腹脂率显著升高,肝脏呈现一定的脂肪变性;与高能量低蛋白质日粮组比较,防治组鸡产蛋性能、HDL-C含量显著升高,TG、TC、LDL-C、ALT、AST、肝脂率和腹脂率显著降低。结果提示,采用高能低蛋白日粮饲喂蛋鸡可以成功的建立蛋鸡脂肪肝出血征病理模型;在高能量低蛋白质日粮中添加0.3mg/kg生物素后,可显著影响蛋鸡的脂肪肝出血征蛋鸡脂类代谢,一定程度上对其具有预防作用。 相似文献
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1. Two long-term experiments were conducted with Single Comb White Leghorn (SCWL) hens (line UCD-003) predisposed to fatty liver haemorrhagic syndrome (FLHS). The first investigated the effect of adding a fatty liver supplement to the diet of laying hens prior to the onset of lay, and continuing either until peak production or throughout 39 weeks into lay. The second experiment, lasting 9 months into lay, investigated the effect of adding a fatty liver supplement, with or without 100 g/kg dietary ground flaxseed, to the diet. Body weight, feed intake, plasma triglycerides (in experiment 2) and egg production were measured throughout the experiment. Liver weight, liver fat content, liver malondialdehyde (MDA) content and liver haemorrhage score and fatty acid content of liver fat (in experiment 2) were measured at the end of each experiment. 2. In experiment 1, hens given diets containing the fatty liver supplement had higher egg production and eggshell strength, but there was no difference in liver parameters including MDA content or haemorrhage score compared with controls. 3. At the end of experiment 2, hens on 100 g/kg flaxseed diets had lower body weight, liver weight, liver dry matter and fat content, and plasma triglyceride concentrations than hens given the control diets. 4. Liver haemorrhage score was positively correlated with liver weight, but not with liver fat content, plasma triglyceride concentration or liver MDA content. This suggests that reducing the liver lipid content or feeding fatty liver supplements may not be as effective in controlling FLHS as controlling the size of the liver. 相似文献
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Gang Peng Enfu Huang Jiming Ruan Liumei Huang Haiping Liang Qing Wei Xianhua Xie Qingjie Zeng Jianzhen Huang 《Animal Science Journal》2019,90(2):247-254
Cidea and Cidec are two members of Cell death‐inducing DNA fragmentation factor‐alpha‐like effector family proteins, which could be involved in lipid or fat metabolism. To better understand the roles of Cidea and Cidec in fatty liver hemorrhagic syndrome (FLHS), 150 healthy 155‐day‐old Hyline Brown laying hens were randomly divided into control group (fed with basic diet) and experimental group (fed with high‐energy low‐protein [HELP] diet). Analysis of the liver by tissue sectioning and hematoxylin and eosin staining showed that the HELP diet induced micro‐vesicular steatosis in laying hens. Subsequently, based on the liver color scores and the range of lipid accumulation observed in histological examination, we classified livers with <50% vacuolization as mild FLHS and >50% as severe FLHS. The results showed that the levels of Cidea and Cidec mRNA expression were markedly elevated in the liver and adipose tissues with FLHS and the levels of Cidea and Cidec mRNA expression in the liver with severe FLHS were significantly higher than that in the liver with mild FLHS. Thus, the present study revealed that the Cidea and Cidec genes may be involved in pathways of FLHS formation. 相似文献
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旨在提高衰老蛋鸡的产蛋量,蛋鸡腹腔注射10 mg·kg-1芦荟大黄素,每天1次,连续7 d,研究天然的芦荟大黄素对580日龄(D580)衰老蛋鸡卵巢重量、卵泡数量和体重变化的影响。本试验建立D-gal诱导的衰老卵泡模型,探究芦荟大黄素对卵泡衰老过程中抗氧化能力、细胞凋亡和增殖的影响,然后检测芦荟大黄素对体外衰老卵泡模型中Nrf2/HO-1信号通路相关蛋白和基因表达水平的影响,以及Nrf2激活剂和阻断剂对芦荟大黄素引起的衰老卵泡氧化应激缓解作用的变化。结果表明,芦荟大黄素处理可提高各级卵泡的数量(P < 0.05),其中,大黄卵泡、小黄卵泡、大白卵泡和小白卵泡数量分别提高32.00%、34.62%、50.00%和54.21%。同时,芦荟大黄素处理使D580蛋鸡血清中雌二醇(E2)和孕酮(P4)水平分别提高34.14%和680.00%。芦荟大黄素处理还可提高卵泡中雌激素受体(ERα和ERβ)和肝中甘油三酯(triglyceride, TG)的含量(P < 0.05)。D580蛋鸡肝组织中脂肪酸合成相关基因的转录水平显著下调,但芦荟大黄素处理可提升这些基因的转录水平。此外,芦荟大黄素通过提高卵泡抗氧化酶的活性、Nrf2/HO-1信号通路相关蛋白和基因的表达,缓解自然衰老和D-gal诱导的衰老卵泡的氧化应激。芦荟大黄素处理可促进衰老卵泡细胞增殖,抑制其凋亡。综上表明,芦荟大黄素通过激活Nrf2/HO-1信号通路缓解蛋鸡卵泡的氧化应激,提升蛋鸡衰老过程中卵泡雌激素受体基因和肝卵黄生成相关基因的表达量、血清E2和P4水平、卵泡抗氧化能力以及肝TG合成能力,从而缓解卵泡衰老。 相似文献
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二氢吡啶(diludin)抗蛋鸡脂肪肝的机理 总被引：8，自引：0，他引：8
30周龄罗曼蛋鸡 80 0只 ,随机分为 2组 (每组设 4个重复 ,每个重复 10 0只 ) ,分别饲喂添加二氢吡啶 (diludin) 0、15 0 m g/ kg的玉米豆粕日粮 ,分别于试验 2 0周和 40周采血和屠宰 ,研究了二氢吡啶抗蛋鸡脂肪肝的机制。结果显示 ,日粮中添加二氢吡啶 ,试验鸡于 5 0、70周龄时 ,肝脂率和腹脂率均显著降低 (P<0 .0 5或 P<0 .0 1) ;腹脂激素敏感脂酶 (HSL )活性显著提高 (P<0 .0 5或 P<0 .0 1) ,脂蛋白脂酶 (L PL )活性显著降低 (P<0 .0 5或 P<0 .0 1) ,肝脏中NADPH生成酶 - MDH活性显著降低 (P<0 .0 1) ;血清脂肪酶活性和游离脂肪酸、极低密度脂蛋白胆固醇含量显著提高 (P<0 .0 5或 P<0 .0 1) ;血清甘油三酯含量降低 (P<0 .0 5或 P<0 .0 1) ;血清超氧化物歧化酶和 T3 显著提高 (P<0 .0 5或 P<0 .0 1) ;肝脏、腹脂中环腺苷酸 (c AMP)含量显著提高 (P<0 .0 5 )。上述结果表明 ,二氢吡啶通过促进产蛋中后期蛋鸡肝脏中脂肪的迁移和体脂的分解 ,达到抗脂肪肝效果。 相似文献
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本试验旨在研究甜菜碱对蛋鸡脂肪肝出血综合征的预防效果。选用300日龄海蓝褐蛋鸡120只,随机分为3组,每组4个重复,每个重复10只,在自由采食、饮水和光照16 h的条件下,分别饲喂正常日粮（代谢能11.30 MJ/kg,粗蛋白质17.20%）、高能量低蛋白质日粮（代谢能12.81 MJ/kg,粗蛋白质13.04%）和添加1000 mg/kg甜菜碱的高能量低蛋白质日粮60 d。于试验期第1、30、60天,每组取8只鸡采血制备血清和采集肝脏样品及腹脂,测定血脂含量、肝脂率和腹脂率,结合产蛋性能及病理学变化,综合判定脂肪肝出血综合征(fatty liver hemorrhagic syndrome,FLHS)的发生及甜菜碱的预防效果。结果表明,与对照组相比,饲喂高能量低蛋白质日粮30 d即可引发FLHS,饲喂60 d则病情进一步加重;而在高能量低蛋白质日粮中添加1000 mg/kg甜菜碱后,饲喂30 d时甜菜碱可显著抑制FLHS的发生,具有很好的预防作用,但饲喂60 d时甜菜碱的预防作用减弱。 相似文献
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Whitehead CC 《The Veterinary quarterly》1979,1(3):150-157
Summary There are two metabolic disorders of major commercial importance in poultry that involve the occurrence of fatty deposits in the liver. Fatty Liver and Kidney Syndrome (FLKS) affects young birds and the main manifestations, lipid infiltrations into liver and many other organs, are apparently secondary effects of the primary lesion that lies in carbohydrate metabolism. Although several nutritional and environmental factors influence FLKS, the main factor is the vitamin, biotin. In the absence of an adequate supply of biotin, the hepatic activity of pyruvate carboxylase, a biotin-dependent enzyme, becomes so low that gluconeogenesis in the liver via pyruvate becomes negligible. When the bird is then subject to a mild stress and 1or short term fasting, liver glycogen reserves become rapidly depleted and a progressive hypoglycaemia develops that ultimately proves fatal. Supplementing diets with adequate amounts of biotin can prevent the syndrome. Fatty Liver Haemorrhagic Syndrome (FLHS) is brought about by an excessive accumulation of fat in the livers of adult hens which weakens the cellular structure of the liver and allows fatal haemorrhaging to occur. The aetiology of the syndrome is not clear, but a major factor is an excessive intake of dietary energy. However, Me involvement of hormonal and toxicological factors, as well as other nutritional factors, is also possible. 相似文献
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The aim of this study was to observe the expression and localization of estrogen receptor (ER) α and ER β mRNA in the medullary bone of laying hens. First, medullary bone, liver, kidney, and shell gland of the oviduct tissues were dissected from laying hens. Then, the total cellular RNA was isolated from each tissue specimen, and the ER α and ER β mRNA expression was observed using semiquantitative RT‐PCR. Second, the localization of ER α mRNA in the medullary bone was detected with in situ hybridization using digoxigenin‐11‐UTP‐labeled cRNA probes. As a result, the expression of ER α mRNA was higher than that of ER β mRNA in the medullary bone, liver, and shell gland of the oviduct from laying hens. In the kidney, ER α mRNA expression was lower than that of ER β mRNA. The expression pattern of ER α and ER β mRNA of the medullary bone was similar to that of the shell gland of the oviduct. Moreover, ER α mRNA was intensively expressed in osteoblasts on the medullary bone surface and bone marrow stromal cells but was not expressed in osteoclasts. These results suggest that in medullary bone, estrogen action may be regulated not by ER β but by ER α. 相似文献