共查询到19条相似文献，搜索用时 375 毫秒
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动物肠道存在复杂的微生物群落,适宜的微环境有利于多种肠道微生物的定植生长。肠道健康是保证动物机体健康的基础,也是当前国内外学者所关注的热点问题。益生菌是对肠道健康有益的微生物,在改善动物肠道健康领域具有极大的潜力。益生菌对病原微生物侵袭有一定的抑制作用,对部分病毒也具有一定的预防及清除作用,但不同菌株作用效果存在较大差异。作者首先将益生菌对肠道健康的保护概括为益生菌抑制病原菌入侵和定植、改善肠道屏障功能、维持肠道健康菌群、提高机体免疫力4种方式,并探讨了不同菌株的作用方式;其次简述了益生菌抗肠道病毒的作用机制,其中,益生菌通过间接方式调节机体免疫是其抗病毒的主要方式;最后讨论了近年来益生菌在轮状病毒、流行性腹泻病毒和传染性胃肠炎病毒中应用的研究进展,并对益生菌的发展前景进行了展望,以期为益生菌在改善动物肠道健康的研究及产品的开发方面提供一定的参考依据。 相似文献
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益生菌在犬猫上的应用研究进展 《畜牧与饲料科学》2022,43(3):46-52
益生菌是一种定植于宿主肠道,能够调节肠道微生态平衡,提高宿主机体健康水平的活菌制剂。目前益生菌已被证实能够对动物起到多种有益的作用。随着宠物医疗行业的快速发展,犬猫的健康越来越受到主人的重视,益生菌被广泛添加到宠物食品以及营养补充剂中,通过维持肠道微生态的平衡达到预防肠道疾病或提高肠道免疫力的目的。对益生菌的定义、种类和作用机制,以及益生菌在犬猫上的应用研究进展进行综述,以期为犬猫益生菌制剂的开发以及益生菌在宠物医疗行业的应用提供参考。 相似文献
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益生菌通过调控猪肠道菌群的数量和丰度、产生生物活性物质和降低肠道p H等路径有效改善肠道微生态环境,增加猪体免疫力,促进猪肠道对营养物质的吸收,提高生产性能以及改善猪胴体品质。文章综述了益生菌的种类及特性、益生菌的作用机理及其在猪生产中的应用,以期为益生菌改善猪肠道健康的深入研究提供理论支持和实践借鉴。 相似文献
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ZHANG Man JIN Xin TIAN Qiao-zhen LIU Jiao WANG Yun-he ZHANG Zhao-yi YANG Yin-feng 《中国畜牧兽医》2017,44(12):3656-3662
Probiotics are a kind of living microorganism which can be administered in feed and confer numerous health benefits to animals. Probiotics play a key role in maintaining the microbial balance of gastrointestinal, immunomodulation and pathogen defense, specific probiotics show certain degree of potential to reinforce the integrity of intestinal epithelium and regulate some immune components. The mechanism of probiotic action is an area of interest. Among all possible routes of modulation by probiotics of intestinal mediated defense responses, modulations of intestinal barrier function, innate and adaptive mucosal immune responses as well as signaling pathways are considered to play an important role in the intestinal defense responses against pathogenic bacteria. This review summarizes how probiotic bacteria interact with goblet cell-derived mucins, trefoil factors (TFFs),defensins, Toll-like receptors (TLRs), secretory immunoglobulin A (sIgA), heat shock proteins (HSPs) and P-glycoproteins (P-gp) in the gut to regulate the intestinal innate defense responses,which is regarded as the scientific basis for the future detailed study of benefits of probiotics towards the health of intestine and also dietary intervention against intestinal exposure to pathogens. 相似文献
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益生菌是可添加在饲料中对动物健康产生很多益处的活微生物,其在维持胃肠道微生物平衡、免疫调节和病原体防御中起关键作用,某些特定的益生菌菌株对加强肠上皮的完整性和调节一些免疫组分也显示出一定程度的潜力。有关益生菌的作用机制是当前研究的热点,其中,在益生菌调节肠道介导的防御反应的所有可能途径中,肠屏障功能、先天和适应性黏膜免疫反应及信号传导途径被认为在针对病原菌的肠防御反应中起重要作用。作者主要针对益生菌如何与肠道内的杯状细胞黏蛋白、三叶因子（trefoil factors,tffs）、防御素、Toll样受体（Toll-like receptors,TLRs）、分泌型免疫球蛋白A（secretory immunoglobulin A,sIgA）、热休克蛋白（heat shock proteins,HSPs）和P-糖蛋白（P-glycoprotein,P-gp）相互作用而起到调节肠道先天防御反应的作用进行了概述,以期为今后研究益生菌对肠道健康及对感染病原体的肠道如何起到有益作用奠定基础。 相似文献
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A. Schoster J.S. Weese L. Guardabassi 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2014,28(6):1640-1652
The gastrointestinal microbiota is extremely important for human and animal health. Investigations into the composition of the microbiota and its therapeutic modification have received increasing interest in human and veterinary medicine. Probiotics are a way of modifying the microbiota and have been tested to prevent and treat diseases. Probiotics are proposed to exert their beneficial effects through various pathways. Production of antimicrobial compounds targeting intestinal pathogens, general immune stimulation, and colonization resistance are among these mechanisms. Despite widespread availability and use, scientific, peer‐reviewed evidence behind commercial probiotic formulations in horses is limited. Additionally, quality control of commercial over‐the‐counter products is not tightly regulated. Although promising in vitro results have been achieved, in vivo health benefits have been more difficult to prove. Whether the ambiguous results are caused by strain selection, dosage selection or true lack of efficacy remains to be answered. Although these limitations exist, probiotics are increasingly used because of their lack of severe adverse effects, ease of administration, and low cost. This review summarizes the current evidence for probiotic use in equine medicine. It aims to provide veterinarians with evidence‐based information on when and why probiotics are indicated for prevention or treatment of gastrointestinal disease in horses. The review also outlines the current state of knowledge on the equine microbiota and the potential of fecal microbial transplantation, as they relate to the topic of probiotics. 相似文献
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