共查询到18条相似文献，搜索用时 250 毫秒
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肿瘤已经成为影响伴侣动物生存和生活质量的主要疾病之一,伴侣动物临床罹患多种复杂、高异质性肿瘤,然而目前临床却面临无药可用的尴尬局面。相较于人肿瘤治疗目的,伴侣动物肿瘤治疗更关注患肿瘤动物生活质量的改善。非细胞毒类抗肿瘤药的靶向作用在肿瘤治疗过程中可以极大减少药物对伴侣动物自身的伤害,因而,被越来越多的研发者所关注。结合伴侣动物用非细胞毒类抗肿瘤药临床试验文献及技术指南要求对伴侣动物用非细胞毒类抗肿瘤药研发中的临床试验设计、疗效评价及其要点进行分析,旨在为伴侣动物非细胞毒类肿瘤药研发者提供参考。 相似文献
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血药浓度法生物等效性试验是兽药生物等效性研究的重要方法。为科学规范兽用化学药品生物等效性研究,保障兽药安全、有效、质量可控,在已发布实施的《兽用化学药品生物等效性试验指导原则》基础上,农业农村部兽药评审中心参考相关最新技术指导原则,结合国内兽药研究现状,修订发布了《兽用化学药品血药浓度法生物等效性试验技术指导原则》。本文针对该指导原则的适用范围、试验设计的内容进行阐述,旨在加强研发单位或相关临床试验机构对此指导原则的理解,对生物等效性试验的有效开展提供指导与帮助。 相似文献
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兽药的研发趋势从销售额的变化中明显的表现出来,近年来,国外动物保健品市场有两大趋势,即宠物（伴侣动物）用药销售额呈大幅增长,但食品动物药呈下降趋势（表3）。1996年世界宠物药销售额为34亿美元。占当年总销售额的22．9％,到2007年销售额达74．9亿美元, 相似文献
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河南牧翔动物药业有限公司是集禽药研发、生产、销售为一体的现代化高新技术企业。牧翔药业一直坚持自主、创新的研发道路，分别在治疗类、预防类、保健类、环境护理类、营养补充类产品的研发上取得了长足的进步和卓越的成就。作为禽业健康的领航者，秉持禽药专注、品牌动作、合作共赢的发展理念，全心全意为家禽养殖业的健康发展保驾护航。 相似文献
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Veterinary clients often seek the same new and innovative cancer treatment options for their companion animals that they read about in the press or on the Internet. It is, therefore, necessary for the practitioner to have an understanding of the development of new and innovative cytotoxic drugs and delivery techniques. This article describes the drug development process and how a new product eventually finds its way into clinical use. Some of the newer drugs and delivery techniques applied to small animals are reviewed. 相似文献
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Conduct,Oversight, and Ethical Considerations of Clinical Trials in Companion Animals with Cancer: Report of a Workshop on Best Practice Recommendations 
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下载免费PDF全文 R. Page P. Baneux D. Vail L. Duda P. Olson L. Anestidou N. Dybdal G. Golab W. Shelton M. Salgaller C. Hardy 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2016,30(2):527-535
Development of effective and safe treatments for companion animals with cancer requires the collaboration of numerous animal health professionals and the full engagement of animal owners. Establishing ‘Best Practice Recommendations’ for clinical trials in veterinary oncology represents an important step toward meeting the goal of rigorous clinical trial design and conduct that is required to establish valid evidence. Likewise, optimizing patient welfare and owner education and advocacy is crucial to meet the unique ethical obligations to both owners and animals enrolled in these clinical trials and to ensure trust in the team conducting the research. To date, ‘Best Practice Recommendations’ for clinical trial conduct have not been reported for veterinary oncology. This document summarizes the consensus of a workshop held in November, 2014 to identify relevant ethical principles and to ensure responsible conduct of clinical research in companion animals with cancer. It is intended as a working document that will be updated as advances in science and ethical considerations require. To the extent possible, existing guidelines for the conduct and oversight of clinical trials in humans have been adapted for veterinary trials to avoid duplicative effort and to facilitate integration of clinical trials such that translational research with benefits for both companion animals and humans are encouraged. 相似文献
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There is a widespread belief that interaction with an animal is beneficial for the development of children, and several studies (most with methodological shortcomings) have investigated the influence of (companion) animals on the social-emotional and cognitive development of children. In this article, the 1984 model of Professor Jay Belsky has been used to describe which variables influence the development of children and how the companion animal-child interaction influences these variables. The value of the AAA/AAT (Animal Assisted Activities/Animal Assisted Therapy) programmes in children with a wide variety of clinical and social problems, such as behaviour problems and autistic spectrum symptoms, is discussed. The findings suggest that (companion) animals positively influence children's development and have a valuable role in therapy. 相似文献
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弓形虫病是一种呈全球分布的重要的人兽共患寄生虫病,能感染包括人在内的所有温血动物。目前对该病的防控主要依赖药物。临床上联合使用磺胺嘧啶与乙胺嘧啶是目前治疗弓形虫病的黄金标准,但该疗法具有一定的毒副作用,且长期使用易产生耐药性。因此,针对弓形虫病的药物研究一直是研究热点。螺旋霉素、甲氧苄啶－磺胺甲噁唑等常作为替代药物用于弓形虫病的治疗,但均具有不同的局限性。因而,人们将研究重点转移到天然产物上。研究以植物提取物为主,通过筛选具有抗弓形虫的活性分子,并对其进行适当的化学修饰,可增强抗虫活性,降低毒副作用。在动物提取物中,某些动物的毒液具有抗弓形虫活性,可作为候选药物。随着研究手段的提升,一些原有药物的新活性不断被发现。在"旧"药新用研究方向,一方面以亲缘关系为标准,针对其他抗寄生虫药物进行抗弓形虫活性探索;另一方面以药物作用靶点为标准,对治疗其他疾病的药物进行抗弓形虫活性研究。文章对弓形虫病临床用药史、天然产物的开发及"旧"药新用这3个方面进行综述,以期为抗弓形虫病药物的研究提供新的思路。 相似文献
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EJ Pleydell K Souphavanh † KE Hill NP French DJ Prattley 《New Zealand veterinary journal》2013,61(2):115-122
Abstract AIM: To describe the patterns of use of antimicrobial drugs by veterinary surgeons treating commonly presented bacterial infections in companion animals in New Zealand. METHODS: A postal survey of 800 randomly selected companion animal veterinarians practicing in New Zealand was conducted between August and December 2008. Data were collected regarding the antimicrobials prescribed for recent cases of skin, ear and urinary tract infections; the use of culture and susceptibility testing; and veterinarian characteristics such as proportion of time spent treating companion animals and recent attendance at continuing professional development (CPD) events. Potential associations within the data were explored using extended mosaic plots and multivariable regression models. RESULTS:Completed surveys from 393 respondents were available for analysis, providing data on systemic antimicrobial drug use for 1,799 cases of presumptive bacterial infections. The most frequently prescribed drugs were amoxicillin-clavulanic acid (864 cases, 48%), cephalexin (558, 31%), and fluoroquinolones (198, 11%). Of 359 cases of canine superficial pyoderma, 157 (44%) were treated with amoxicillin-clavulanic acid and 155 (43%) were treated with cephalexin with median reported treatment durations of 7 and 10 days, for these two drugs respectively. Culture and susceptibility tests had been used in 376 of 1,984 (19%) of all reported cases and 160 (43%) of these were suspected urinary tract infections. Practitioners that spent 100% of their time treating companion animals and who had attended a CPD course related to companion animals within the 12 months prior to completing the survey were more likely to submit a sample for culture and susceptibility testing and to prescribe longer courses of antimicrobials for the treatment of canine pyoderma than practitioners who spent less than 100% of their time treating companion animals and had not attended a CPD course in the last 12 months. CONCLUSIONS: Broad-spectrum drugs considered by the World Health Organisation to be critically important for human health, such as fluoroquinolones and amoxicillin-clavulanic acid, are amongst the most frequently prescribed antimicrobials in companion animal medicine, and these drugs are often prescribed without submitting a sample for culture and susceptibility testing. CLINICAL RELEVANCE: Many cases of superficial pyoderma were treated for less than the recommended duration of 21 days, which may contribute to a higher rate of recurrent pyoderma and the development of drug resistance within the causal bacteria. Veterinarians should be aware that the use of fluoroquinolones, in particular, should be based upon the results of a culture and susceptibility test. 相似文献
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Prospects for discovering new antiparasitic drugs for veterinary medicine in the coming century will be determined by economic, social and scientific factors. Consolidation in the pharmaceutical industry in general, and the animal health industry in particular, changes the business conditions in which drug discovery for veterinary medicine occurs. Social pressures on traditional animal agriculture and companion animal ownership have shifted the interest of animal companies primarily to pet medicine. Antiparasitic drug discovery is more than ever targeted to the most lucrative market segments, but the excellence of available drugs, and the apparent lack of resistance in important parasites, reduces industrial motivation to invest in parasitology. Veterinary parasitologists in academia will still have the chance to interact with their industrial counterparts in the traditional ways of supporting drug discovery and development. Nonetheless, there are many new opportunities to expand the research horizons of veterinary parasitology to strengthen the case for retaining a significant presence in the animal health industry. 相似文献
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《Journal of Exotic Pet Medicine》2014,23(1):39-49
It is imperative that the veterinarian treating exotic companion mammals stay abreast of the latest developments relating to medications and drug delivery approaches for safety and efficacy. Sustained-release formulations of commonly used drugs, as well as newer routes for administration of therapeutic agents, allow the veterinarian treating exotic companion mammals to reduce the stress associated with drug administration. Interactions can occur between vehicle and drugs when formulations are compounded; therefore, research studies are warranted regarding potential problems associated with these formulations. However, newer studies have been published that provide the basis for exploring the use of different vehicles, frequency of dosing, and drug delivery techniques for various classes of drugs in exotic mammals. The goals of this review are to not only evaluate new medications or uses for medications in companion exotic mammal patients but also review new methods of drug delivery that might be useful to the veterinarian who treats these animals. 相似文献
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Biology and medicine of the ferret 总被引：1，自引：0，他引：1
C L Besch-Williford 《Veterinary Clinics of North America: Small Animal Practice》1987,17(5):1155-1183
There is still much more to be learned about ferret behavior, nutrition, and physiologic responses associated with aging, disease, and environmental stimuli. The many similarities in the clinical disorders of ferrets and other small companion animals should emphasize the importance of using the same diagnostic methods developed for common companion animals in examinations of ferrets. There is still very little known of the efficacy of a wide spectrum of drugs in ferrets, and judicious use of pharmacodynamic agents that are safe for cats would be a reasonable approach to drug therapy. 相似文献