Verrucosamide,a Cytotoxic 1,4-Thiazepane-Containing Thiodepsipeptide from a Marine-Derived Actinomycete     

Vimal Nair  Min Cheol Kim  James A. Golen  Arnold L. Rheingold  Gabriel A. Castro  Paul R. Jensen  William Fenical 《Marine drugs》2020,18(11)

A new cytotoxic thiodepsipeptide, verrucosamide (1), was isolated along with the known, related cyclic peptide thiocoraline, from the extract of a marine-derived actinomycete, a Verrucosispora sp., our strain CNX-026. The new peptide, which is composed of two rare seven-membered 1,4-thiazepane rings, was elucidated by a combination of spectral methods and the absolute configuration was determined by a single X-ray diffraction study. Verrucosamide (1) showed moderate cytotoxicity and selectivity in the NCI 60 cell line bioassay. The most susceptible cell lines were MDA-MB-468 breast carcinoma with an LD₅₀ of 1.26 µM, and COLO 205 colon adenocarcinoma with an LD₅₀ of 1.4 µM. Also isolated along with verrucosamide were three small 3-hydroxy(alkoxy)-quinaldic acid derivatives that appear to be products of the same biosynthetic pathway.  相似文献   

The ecosystem services concept: a new Esperanto to facilitate participatory planning processes?     

Spyra  Marcin  Kleemann  Janina  Cetin  Nuket Ipek  Vázquez Navarrete  Cesar Jesús  Albert  Christian  Palacios-Agundez  Igone  Ametzaga-Arregi  Ibone  La Rosa  Daniele  Rozas-Vásquez  Daniel  Adem Esmail  Blal  Picchi  Paolo  Geneletti  Davide  König  Hannes J.  Koo  HongMi  Kopperoinen  Leena  Fürst  Christine 《Landscape Ecology》2019,34(7):1715-1735

Landscape Ecology - Several case studies investigated the role of ecosystem services in participatory planning processes. However, no systematic study exists that cuts across a large number of...  相似文献   

Natural antibacterial compounds on the surface of rainbow trout, Salmo gairdneri Richardson     

B. AUSTIN  D. McINTOSH 《Journal of fish diseases》1988,11(3):275-277

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Immunodeficiency associated with lymphosarcoma in a horse.     

M O Furr  M V Crisman  J Robertson  O Barta  W S Swecker 《Journal of the American Veterinary Medical Association》1992,201(2):307-309

Immune system dysfunction and immunoglobulin deficiency was diagnosed in a 2-year-old horse with disseminated lymphosarcoma. Prolonged (35 days) parenteral nutrition was delivered to support the horse during a period in which immune function studies could be performed. Correction of nutritional compromise by use of parenteral nutrition did not correct the immunoglobulin deficiency, and results of lymphocyte phenotype testing did not indicate abnormal proportions of leukocytes. Lymphoblast transformation studies were suggestive of a circulating immunosuppressive factor in the horse's serum. Normal cell function was detected when the cells were stimulated in precolostral equine serum.  相似文献   

Cryptococcal osteomyelitis in a dog     

M. J. Brearley  N. Jeffery 《The Journal of small animal practice》1992,33(12):601-604

Osteomyelitis caused by Cryptococcus neoformans was diagnosed in a three-year-old male Irish wolfhound. The case details and radiological findings of radiolucency and periosteal reaction of the left third metatarsal bone had lead to an initial diagnosis of a malignant bone tumour. Biopsy revealed a fungal granuloma and culture identified the causal organism. A four month course of ketaconazole was instigated and the lameness resolved. Twelve months after the end of treatment there was no recurrence of the problem.  相似文献   

Comparative virulence of Haemophilus parasuis serovars 1 to 7 in guinea pigs.     

V J Rapp-Gabrielson  D A Gabrielson  G J Schamber 《American journal of veterinary research》1992,53(6):987-994

Reference strains for Haemophilus parasuis serovars 1 to 7 were examined for virulence by inoculation of guinea pigs. Guinea pig response to intraperitoneal inoculation was similar for the 7 reference strains. However, apparent differences in virulence were detected after intratracheal inoculation. Cells of the references strains for serovars 1 and 5 were most invasive, causing moribundity or death at higher doses and a persistent septicemia at lower doses. Haemophilus parasuis could be isolated from respiratory and systemic sites; purulent bronchopneumonia, pericarditis, and pleuritis were apparent in infected guinea pigs. Inoculation of cells of the reference strains for serovars 2 and 6 also resulted in bronchopneumonia and moribundity or death in some guinea pigs; however, reisolation of H parasuis and microscopic lesions at necropsy were less pronounced than those observed with serovars 1 and 5. Inoculation of cells of serovars 3, 4 and 7 induced only transient clinical signs and minimal evidence of H parasuis infection at necropsy. The data from intratracheal inoculation of guinea pigs are similar to data from other investigations in swine, indicating differences in the pathogenic potential of H parasuis strains. Thus, guinea pigs may be useful as a laboratory animal model for examining cellular factors associated with virulence and immunogenicity of H parasuis.  相似文献   

Role of nutrition in aetiology and treatment of diarrhoea     

J. W. Simpson 《The Journal of small animal practice》1992,33(4):167-171

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Genotypic Variability in Biomass Protein and Nucleic Acids in Four Linum Species to Sodicity Stress     

A. K. Singh  B. B. Singh 《Journal of Agronomy and Crop Science》1991,167(1):1-7

Differences in gas exchange parameters i.e. carbon exchange rate (CER), transpiration (Tr), water vapor conductance (g) were investigated, under a controlled environment, in a semi-dwarf (SD) Triticum aestivum line, its tall (TL) near isoline and the Payne (PA) variety characterized by small leaves. The plants were maintained in: (a) optimal substrate moisture condition (CTR); (b) salinized by watering with a 0.12 m NaCl solution (SLT); (c) water stressed by withholding waterings during a period of six days (STR); (d) stressed and salinized during the same period and with the same saline solution (S + S). CER and Tr were negatively affected by the stresses; SLT and S + S treatments had a higher WUE compared to their respective controls CTR and STR.
SD line had a better performance in terms of CER and WUE, particularly when water and salt stresses interacted. Leaf anatomy and assimilation/internal CO₂ concentration curves contributed to explaining the SD performance.  相似文献   

Editorial     

C. Guillermo Couto 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1994,8(2):71-71

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Antibody response to crustacean ectoparasites in rainbow trout, Oncorhynchus mykiss (Walbaum), immunized with Argulus foliaceus L. antigen extract     

N. RUANE  T. K. MCCARTHY  P. REILLY 《Journal of fish diseases》1995,18(6):529-537

Abstract. A humoral antibody response was demonstrated by ELISA in rainbow trout immunized intraperitoneally with extracts from the branchiuran ectoparasite Argulus foliaceus. A similar immunization protocol produced a higher titre response in a rabbit. Both trout and rabbit identified several antigenic components on immunoblots. ELISA and immunoblotting indicated that rainbow trout and rabbit anti-A. foliaceus sera identified components from the parasitic copepods Lepeophtheirus salmonis and Caligus elongatus.  相似文献