Assessment of insecticidal effects and selectivity of CAPA‐PK peptide analogues against the peach‐potato aphid and four beneficial insects following topical exposure     

Shun‐Hua Gui  Clauvis NT Taning  Kristof De Schutter  Qun Yang  Pengyu Chen  Mohamad Hamshou  Ronald J Nachman  Aniruddha A Pandit  Julian AT Dow  Shireen Davies  Guy Smagghe 《Pest management science》2020,76(10):3451-3458

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Toward the Identification of Novel Antimicrobial Agents: One-Pot Synthesis of Lipophilic Conjugates of N-Alkyl d- and l-Iminosugars     

Anna Esposito  Daniele D&#x;Alonzo  Stefano D&#x;Errico  Eliana De Gregorio  Annalisa Guaragna 《Marine drugs》2020,18(11)

In the effort to improve the antimicrobial activity of iminosugars, we report the synthesis of lipophilic iminosugars 10a–b and 11a–b based on the one-pot conjugation of both enantiomeric forms of N-butyldeoxynojirimycin (NBDNJ) and N-nonyloxypentyldeoxynojirimycin (NPDNJ) with cholesterol and a succinic acid model linker. The conjugation reaction was tuned using the established PS-TPP/I₂/ImH activating system, which provided the desired compounds in high yields (94–96%) by a one-pot procedure. The substantial increase in the lipophilicity of 10a–b and 11a–b is supposed to improve internalization within the bacterial cell, thereby potentially leading to enhanced antimicrobial properties. However, assays are currently hampered by solubility problems; therefore, alternative administration strategies will need to be devised.  相似文献   

A New Bioassay Platform Design for the Discovery of Small Molecules with Anticancer Immunotherapeutic Activity     

Carmela Gallo  Giusi Barra  Marisa Saponaro  Emiliano Manzo  Laura Fioretto  Marcello Ziaco  Genoveffa Nuzzo  Giuliana d&#x;Ippolito  Raffaele De Palma  Angelo Fontana 《Marine drugs》2020,18(12)

Immunotherapy takes advantage of the immune system to prevent, control, and eliminate neoplastic cells. The research in the field has already led to major breakthroughs to treat cancer. In this work, we describe a platform that integrates in vitro bioassays to test the immune response and direct antitumor effects for the preclinical discovery of anticancer candidates. The platform relies on the use of dendritic cells that are professional antigen-presenting cells (APC) able to activate T cells and trigger a primary adaptive immune response. The experimental procedure is based on two phenotypic assays for the selection of chemical leads by both a panel of nine tumor cell lines and growth factor-dependent immature mouse dendritic cells (D1). The positive hits are then validated by a secondary test on human monocyte-derived dendritic cells (MoDCs). The aim of this approach is the selection of potential immunotherapeutic small molecules from natural extracts or chemical libraries.  相似文献   

Crop rotation sequencing to minimize yield losses of summer-irrigated lowland rice in Myanmar caused by the rice root-knot nematode Meloidogyne graminicola     

Pa Pa Win  Pyone Pyone Kyi  Zin Thu Zar Maung  Yi Yi Myint  Dirk De Waele 《国际虫害防治杂志》2020,66(4):319-331

Abstract

The effect of different rice-based crop rotation sequences on the population densities of Meloidogyne graminicola and on the yield of rice was evaluated in a microplot experiment under lowland rice field conditions. Ten treatments of cropping sequences were grown in four successive growing seasons: continuous growing of the susceptible rice cultivar Thihtatyin (rice-rice-rice-rice), four treatments of 1- season crop rotation sequences (rice-rice-chickpea-rice, rice-rice-black gram-rice, rice-rice-soybean-rice, rice-rice-cowpea-rice), and five treatments of 2-season crop rotation sequences (groundnut-rice-chickpea-rice, green gram-rice-black gram-rice, cowpea-rice-soybean-rice, sesame-rice-cowpea-rice, sunflower-rice-sesame-rice). Population densities of M. graminicola recovered from the rice plants and the nematode multiplication factors (Mf) in the soil in the continuous rice cropping sequence (rice-rice-rice-rice) was the highest among the ten cropping sequences. Lowest nematode Mf in the soil was observed in the 2-season crop rotation sequence sunflower-rice-sesame-rice and the highest was observed in the 1-season crop rotation sequence rice-rice-cowpea-rice among the nine crop rotation sequences. Highest rice yield was obtained in the 2-season crop rotation sequences green gram-rice-black gram-rice, sesame-rice-cowpea-rice and sunflower-rice-sesame-rice, which were about 2 times higher compared with the 1-season crop rotation sequences and about 3 times higher compared with the continuous rice cropping sequence.  相似文献   

2019年农机行业10大营销事件     

刘德 《农业机械》2020,(2):65-67

管理学家德鲁克指出,基于顾客,企业只有两项最基本的职能:营销和创新.在当下农机行业进入存量竞争阶段,想要跳出同质化的红海,创新和营销变得特别重要. 2019年已过去,但它留下的印记却是深刻的,尤其是在农机营销领.笔者为大家整理出过去一年农机行业有重大影响的营销事件.  相似文献   

新疆生产建设兵团第八师农田残膜含量及在土壤中分布情况          下载免费PDF全文

卡那特  张兴瑶  李维军  王辉 《农业工程》2020,10(1):45-47

在新疆生产建设兵团第八师农田进行了残膜样品采集,并对不同采样深度下不同面积的农田残膜含量及数量进行统计分析,获取了土壤中残膜的分布情况,旨在为残膜回收机械的设计以及残膜回收策略的制定提供参考。   相似文献   

印楝素与三种杀虫剂对小菜蛾的联合毒力作用   总被引：2，自引：0，他引：2  

赵德  慕卫  张月亮  刘彦良  贺宪民 《山东农业大学学报(自然科学版)》2005,36(1):123-125

采用浸叶浸虫法,测定了印楝素与三种杀虫剂对小菜蛾的室内联合毒力作用,并筛选出了药剂的最佳复配比例。结果表明,印楝素：阿维菌素为2．3：1,共毒系数(CTC)为141．14,增效作用最为显著;印楝素：Bt为1：1,共毒系数为136．74;而印楝素与高效氯氰菊酯混配对小菜蛾表现为相加作用。  相似文献   

Volatile chemical cues guide host location and host selection by parasitic plants     

Runyon JB  Mescher MC  De Moraes CM 《Science (New York, N.Y.)》2006,313(5795):1964-1967

The importance of plant volatiles in mediating interactions between plant species is much debated. Here, we demonstrate that the parasitic plant Cuscuta pentagona (dodder) uses volatile cues for host location. Cuscuta pentagona seedlings exhibit directed growth toward nearby tomato plants (Lycopersicon esculentum) and toward extracted tomato-plant volatiles presented in the absence of other cues. Impatiens (Impatiens wallerana) and wheat plants (Triticum aestivum) also elicit directed growth. Moreover, seedlings can distinguish tomato and wheat volatiles and preferentially grow toward the former. Several individual compounds from tomato and wheat elicit directed growth by C. pentagona, whereas one compound from wheat is repellent. These findings provide compelling evidence that volatiles mediate important ecological interactions among plant species.  相似文献   

基于虚拟仪器的湿增压实验台测控系统研究     

陈景锋  蒋德松 《安徽农业技术师范学院学报》2007,21(6):38-43

本文以湿增压动力装置实验台为物理模型，为进行相关实验完成了速度、流量、扭矩等重要参数的测量，并以N16221硬件为基础，基于虚拟仪器平台LabVIEW研制了实验台的测试软件。新设计的测试系统是基于虚拟仪器平台的模块化系统，使得研究人员的大部分精力集中于所要实现的功能上，而不是以往繁琐的算法和重复的编程上，参数易于修改，缩短了系统开发的周期，能满足实验需求。  相似文献   

泸州地区白背飞虱种群动态及预测预报   总被引：2，自引：0，他引：2  

卿雨文  李春  张志东  刘勇  王东升  邓德军  何大友 《西南大学学报(自然科学版)》2000,22(1):49-52,70

随着杂交稻的广泛种植,白背飞虱已成为泸州地区水稻的重要害虫。通过对泸州市叙永,合江,泸县和古蔺县１９８３￣１９９８年白背飞虱灯诱测报资料和田间系统调查资料的分析,结合异地虫情信息交流,天气资料分析,明确了泸州地区白背飞虱虫源主要由黔南,桂北及以南稻区经东南气流迁飞而来。分析了其主要降落范围、害虫田间消长规律和影响其大发生的主要气候因子。建立了预测预报模型,为指导泸州地区白背飞虱防治提供了科学依据。  相似文献