Comparison of six microscopic methods and two operators for estimation of white and red blood cells in canine urine sediment     

Marco Giraldi  Filippo Tagliasacchi  Saverio Paltrinieri  Tiziana Vitiello  Paola Rossetti  Paola Scarpa 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2023,52(1):71-78

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Prediction of vascular invasion using a 7‐point scale computed tomography grading system in adrenal tumors in dogs     

Pascaline Pey  Swan Specchi  Federica Rossi  Alessia Diana  Ignazio Drudi  Allison L. Zwingenberger  Philipp D. Mayhew  Luciano Pisoni  Daniele Mari  Federico Massari  Boris Dalpozzo  Federico Fracassi  Stefano Nicoli 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2022,36(2):713

BackgroundPrevious studies evaluating the accuracy of computed tomography (CT) in detecting caudal vena cava (CVC) invasion by adrenal tumors (AT) used a binary system and did not evaluate for other vessels.ObjectiveTest a 7‐point scale CT grading system for accuracy in predicting vascular invasion and for repeatability among radiologists. Build a decision tree based on CT criteria to predict tumor type.MethodsRetrospective observational cross‐sectional case study. Abdominal CT studies were analyzed by 3 radiologists using a 7‐point CT grading scale for vascular invasion and by 1 radiologist for CT features of AT.AnimalsDogs with AT that underwent adrenalectomy and had pre‐ and postcontrast CT.ResultsNinety‐one dogs; 45 adrenocortical carcinomas (50%), 36 pheochromocytomas (40%), 9 adrenocortical adenomas (10%) and 1 unknown tumor. Carcinoma and pheochromocytoma differed in pre‐ and postcontrast attenuation, contralateral adrenal size, tumor thrombus short‐ and long‐axis, and tumor and thrombus mineralization. A decision tree was built based on these differences. Adenoma and malignant tumors differed in contour irregularity. Probability of vascular invasion was dependent on CT grading scale, and a large equivocal zone existed between 3 and 6 scores, lowering CT accuracy to detect vascular invasion. Radiologists'' agreement for detecting abnormalities (evaluated by chance‐corrected weighted kappa statistics) was excellent for CVC and good to moderate for other vessels. The quality of postcontrast CT study had a negative impact on radiologists'' performance and agreement.Conclusions and Clinical ImportanceFeatures of CT may help radiologists predict AT type and provide probabilistic information on vascular invasion.  相似文献   

The sounds of silence: regime shifts impoverish marine soundscapes     

Tullio Rossi  Sean D. Connell  Ivan Nagelkerken 《Landscape Ecology》2017,32(2):239-248

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Occupancy pattern of a long-horned beetle in a variegated forest landscape: linkages between tree quality and forest cover across spatial scales     

Pablo M. Vergara  Luis O. Meneses  Audrey A. Grez  Madelaine S. Quiroz  Gerardo E. Soto  Christian G. Pérez-Hernández  Paola A. Diaz  Ingo J. Hahn  Andrés Fierro 《Landscape Ecology》2017,32(2):279-293

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Studies on umami taste. Synthesis of new guanosine 5'-phosphate derivatives and their synergistic effect with monosodium glutamate     

Cairoli P  Pieraccini S  Sironi M  Morelli CF  Speranza G  Manitto P 《Journal of agricultural and food chemistry》2008,56(3):1043-1050

A number of N2-alkyl and N2-acyl derivatives of guanosine 5'-phosphate (GMP) have been synthesized and tested for their synergistic effect with monosodium L-glutamate (MSG), the prototypical substance imparting umami taste to savory-based foods. Capacities to enhance the taste intensity of MSG (gamma values) were estimated through subjective comparisons of MSG/nucleotide mixtures in water with appropriate solutions of MSG alone. Assuming beta = gamma[nucleotide]/gamma[IMP], beta values of the N2-substituted GMPs were found in the range 1.2-5.7. Such values appear to be related to the chain length of the substituent in the 2-position of the purine nucleus and dependent on the replacement of a CH 2 group with an S atom and/or with an alpha-CO group. These findings indicate that the exocyclic NHR group of the guanine moiety is actively implicated in the synergism between GMP derivatives and MSG. Theoretical calculations suggest that an anti conformation is probably assumed by ribonucleotide molecules interacting with umami receptors.  相似文献   

Chemical markers for the evaluation of raw material hygienic quality in egg products     

Hidalgo A  Franzetti L  Rossi M  Pompei C 《Journal of agricultural and food chemistry》2008,56(4):1289-1297

The aim of this research was to study uracil and lactic and acetic acids as chemical markers for hygienic quality evaluation of raw material in liquid pasteurized egg products. Uracil, absent in sound whole eggs, was formed in raw and pasteurized egg products as a consequence of high microbial contamination (>10(6) cfu/g) after a sufficient lag time, remaining stable at 4 degrees C but disappearing after 7 days of storage at 25 degrees C. Both lactic and acetic acids, starting from initial values of 1-7 mg/kg dry matter, presented trends similar to that of uracil; however, acetic acid never decreased during the storage of raw egg products. With few exceptions, all three metabolites were produced by Enterobacter cloacae, Escherichia coli, Morganella morganii, Serratia liquefaciens, Aeromonas hydrophyla, Pseudomonas fluorescens, Enterococcus avium, and Enterococcus faecalis, separately inoculated in whole egg samples. Uracil seems to be the most sensible marker, with a suggested limit corresponding to the detectable level.  相似文献   

Profile and Content of Residual Alkaloids in Ten Ecotypes of Lupinus mutabilis Sweet after Aqueous Debittering Process     

Cortés-Avendaño  Paola  Tarvainen  Marko  Suomela  Jukka-Pekka  Glorio-Paulet  Patricia  Yang  Baoru  Repo-Carrasco-Valencia  Ritva 《Plant foods for human nutrition (Dordrecht, Netherlands)》2020,75(2):184-191

Plant Foods for Human Nutrition - The evaluation of the level of alkaloids in edible Lupinus species is crucial from a food safety point of view. Debittering of lupin seeds has a long history;...  相似文献   

Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes     

Marilia Barreca  Virginia Span  Alessandra Montalbano  Mercedes Cueto  Ana R. Díaz Marrero  Irem Deniz  Ayegül Erdoan  Lada Luki&#x; Bilela  Corentin Moulin  Elisabeth Taffin-de-Givenchy  Filippo Spriano  Giuseppe Perale  Mohamed Mehiri  Ana Rotter  Olivier P. Thomas  Paola Barraja  Susana P. Gaudêncio  Francesco Bertoni 《Marine drugs》2020,18(12)

The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve different pathways than their terrestrial counterparts, thus producing unique chemicals with a broad diversity and complexity. So far, more than 36,000 compounds have been isolated from marine micro- and macro-organisms including but not limited to fungi, bacteria, microalgae, macroalgae, sponges, corals, mollusks and tunicates, with hundreds of new marine natural products (MNPs) being discovered every year. Marine-based pharmaceuticals have started to impact modern pharmacology and different anti-cancer drugs derived from marine compounds have been approved for clinical use, such as: cytarabine, vidarabine, nelarabine (prodrug of ara-G), fludarabine phosphate (pro-drug of ara-A), trabectedin, eribulin mesylate, brentuximab vedotin, polatuzumab vedotin, enfortumab vedotin, belantamab mafodotin, plitidepsin, and lurbinectedin. This review focuses on the bioactive molecules derived from the marine environment with anticancer activity, discussing their families, origin, structural features and therapeutic use.  相似文献   

Occurrence of Mycobacterium spp. in ornamental fish in Italy     

Zanoni RG  Florio D  Fioravanti ML  Rossi M  Prearo M 《Journal of fish diseases》2008,31(6):433-441

The occurrence of Mycobacterium spp. in freshwater and marine ornamental fish was studied in Italy from June 2002 to May 2005. Two surveys were carried out, one of aquarium fish sent to the Laboratory for diagnosis, and the other of prevalence of infection by mycobacteria in ornamental fish imported into Italy. Bacterial isolation was carried out from the spleen, kidney and liver, and the isolates were subsequently identified by biochemical tests. In the first survey, 387 fish were examined and Mycobacterium spp. were isolated from 181 (46.8%) fish. In the second survey 127 batches of ornamental fish from different countries were examined. Mycobacterium spp. were isolated from 38 (29.9%) batches. The following species were found: M. fortuitum, M. peregrinum, M. chelonae, M. abscessus, M. marinum, M. gordonae, M. nonchromogenicum and M. interjectum. There was a high prevalence of infection independent of the presence of macroscopic lesions. Mycobacterium fortuitum and M. chelonae were more prevalent than M. marinum in the samples examined.  相似文献   

Rainbow trout (Oncorhynchus mykiss,Walbaum ) develop a more robust body shape under organic rearing     

Domitilla Pulcini  Tommaso Russo  Paola Reale  Alexia Massa‐Gallucci  Grace Brennan  Stefano Cataudella 《Aquaculture Research》2014,45(3):397-409

Prolonged exposure to captive conditions has led to the development of a rainbow trout ‘farmed’ phenotype, which is different from that of wild trout. Selection for desirable productive traits in hatcheries has resulted in the development of some morphological traits that are maladaptive in nature. The recent development of organic aquaculture, guided by the well‐being of the fish, could potentially produce a new farmed phenotype that would be more adaptive in nature. In this study, rainbow trout reared in intensive and organic farms were compared by means of shape analysis, to detect patterns of shape variation associated with rearing environment. The results of this study highlight a significant effect of the rearing method on rainbow trout shape: organically reared trout showed a higher body profile, in particular in the head and trunk regions, shorter median fins and a deeper caudal peduncle. A combined effect of density and habitat complexity could have contributed to the observed shape differences: in organic rearing systems, lower densities and steady water could increase territoriality and aggressive interactions, promoting body designs more functional in rapid attacks and escapes.  相似文献