Een geval van beschadiging aan Rozen door bliksem     

Dina Spierenburg 《European journal of plant pathology / European Foundation for Plant Pathology》1928,34(9):239-242

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A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels     

Bouatia-Naji N  Rocheleau G  Van Lommel L  Lemaire K  Schuit F  Cavalcanti-Proença C  Marchand M  Hartikainen AL  Sovio U  De Graeve F  Rung J  Vaxillaire M  Tichet J  Marre M  Balkau B  Weill J  Elliott P  Jarvelin MR  Meyre D  Polychronakos C  Dina C  Sladek R  Froguel P 《Science (New York, N.Y.)》2008,320(5879):1085-1088

Several studies have shown that healthy individuals with fasting plasma glucose (FPG) levels at the high end of the normal range have an increased risk of mortality. To identify genetic determinants that contribute to interindividual variation in FPG, we tested 392,935 single-nucleotide polymorphisms (SNPs) in 654 normoglycemic participants for association with FPG, and we replicated the most strongly associated SNP (rs560887, P = 4 x 10(-7)) in 9353 participants. SNP rs560887 maps to intron 3 of the G6PC2 gene, which encodes glucose-6-phosphatase catalytic subunit-related protein (also known as IGRP), a protein selectively expressed in pancreatic islets. This SNP was associated with FPG (linear regression coefficient beta = -0.06 millimoles per liter per A allele, combined P = 4 x 10(-23)) and with pancreatic beta cell function (Homa-B model, combined P = 3 x 10(-13)) in three populations; however, it was not associated with type 2 diabetes risk. We speculate that G6PC2 regulates FPG by modulating the set point for glucose-stimulated insulin secretion in pancreatic beta cells.  相似文献   

Some considerations on veterinary drug use and supply in Nigeria.     

O A Dina  R O Arowolo 《Revue d'élevage et de médecine vétérinaire des pays tropicaux》1991,44(1):29-31

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The response of the Nigerian indigenous chicken (Gallus domesticus) to trypanosomes     

O A Dina  R O Arowolo 《Revue d'élevage et de médecine vétérinaire des pays tropicaux》1988,41(4):365-366

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Een virusziekte in lupinen     

Dina Spierenburg 《European journal of plant pathology / European Foundation for Plant Pathology》1936,42(5):253-254

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Mirabolides A and B; New Cytotoxic Glycerides from the Red Sea Sponge Theonella mirabilis     

Dina R. Abou-Hussein  Diaa T. A. Youssef 《Marine drugs》2016,14(8)

As a part of our continuing work to find out bioactive lead molecules from marine invertebrates, the CHCl₃ fraction of the organic extract of the Red Sea sponge Theonella mirabilis showed cytotoxic activity in our primary screen. Bioassay-guided purification of the active fractions of the sponge’s extract resulted in the isolation of two new glycerides, mirabolides A and B (1 and 2), together with the reported 4-methylene sterols, conicasterol (3) and swinhosterol B (4). The structures of the compounds were assigned by interpretation of their 1D (¹H, ¹³C), 2D (COSY, HSQC, HMBC, ROESY) NMR spectral data and high-resolution mass determinations. Compounds 1–4 displayed marked cytotoxic activity against human breast adenocarcinoma cell line (MCF-7) with IC₅₀ values of 16.4, 5.18, 6.23 and 3.0 μg/mL, respectively, compared to 5.4 μg/mL observed by doxorubicin as reference drug.  相似文献   

Effects of different commercial diets on growth performance,health and resistance to Tetrahymena sp. infection in guppies,Poecilia reticulata (Peters)          下载免费PDF全文

Galit Sharon  Sophie Fridman  Nitzan Reiss‐Hevlin  Tamar Sinai  Pascal Boisot  Dina Zilberg 《Aquaculture Research》2016,47(7):2276-2286

The effects of feeding guppy fry, Poecilia reticulata (Peters), different commercial diets from BernAqua [MeM (R = Regular, O = Ornamental and P = Premium) and experimental feed (EF] and Ocean Nutrition (ON) on growth was tested for 57 days. Health status and resistance to Tetrahymena infection were analysed at the end of the trial. The highest growth was obtained in fish fed MeM Regular and MeM Premium (mean final weights of 427 and 417 mg respectively). Fish fed EF had a significantly higher rate of spinal deformity (12.7%) than all other feeding groups (3.05% or less). Histological analysis revealed the accumulation of liver glycogen and/or lipid in fish from all feeding groups; fat accumulation in the abdomen was most pronounced in the EF and MeM Regular‐fed fish, and muscle dystrophy was observed in ca. 50% of the fish from all feeding groups except the MeM Ornamental‐fed group. The highest mortality following Tetrahymena infection occurred in fish fed EF (87%) and the lowest mortality in the MeM Ornamental‐fed fish (58%). Mortalities in all other feeding groups ranged between 69% and 76%. In summary, MeM Ornamental feed provided a moderate weight gain, no muscle dystrophy, negligible deformity and the greatest resistance to parasitic infection.  相似文献   

Real‐time PCR assay to detect brown marmorated stink bug,Halyomorpha halys (Stål), in environmental DNA          下载免费PDF全文

Rafael E Valentin  Brooke Maslo  Julie L Lockwood  John Pote  Dina M Fonseca 《Pest management science》2016,72(10):1854-1861

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Temporal and spatial distribution of paramoebae in the water column--a pilot study     

Douglas-Helders GM  O'Brien DP  McCorkell BE  Zilberg D  Gross A  Carson J  Nowak BF 《Journal of fish diseases》2003,26(4):231-240

Amoebic gill disease is the main disease affecting the salmonid industry in Tasmania, but no information on the distribution of the causative pathogen, Neoparamoeba pemaquidensis, in the aquatic environment is available. This pilot study aimed to determine temporal and spatial distributions of paramoebae species in the water column, using an immuno-dot blot technique. Water samples were collected from inside fish cages at various depths (0.5, 5.5 and 11.0 m) in both summer and winter, as well as various distances (0, 0.5, 240, 280, 750 and 1100 m) away from the sea cage and farming site. Paramoebae densities were estimated using the most probable number technique (MPN). Temperature, salinity, dissolved oxygen, turbidity, nitrite and nitrates, and bacterial counts were measured for each water sample. Data were analysed using a residual maximum likelihood test and significant associations between paramoebae densities and environmental factors were analysed. Results showed that densities were significantly higher in summer (P = 0.017), at 5.5 m depth (P = 0.029), and reduced to the lowest density at 1100 m away from the cage sites (P = 0.008). Bacterial counts, turbidity and temperature were found to be significantly associated with paramoebae densities.  相似文献   

The effect of anti-Paramoeba antibodies on Paramoeba sp., the causative agent of amoebic gill disease     

D Zilberg  & B L Munday 《Journal of fish diseases》2001,24(6):345-350

The effect of anti- Paramoeba antibodies produced in sheep on Paramoeba sp., the causative agent of amoebic gill disease (AGD), was tested. Incubation of Paramoeba sp. with antiserum at a concentration of 20% or more effectively coated the Paramoeba with antibodies. The antiserum had no effect on Paramoeba sp. survival in vitro or on its ability to cause AGD in Atlantic salmon.  相似文献