Effect of pre‐milking teat disinfection on clinical mastitis incidence in a dairy herd in Northern Queensland,Australia          下载免费PDF全文

SM Rowe  WP Tranter  RA Laven 《Australian veterinary journal》2018,96(3):69-75

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Analysis of gene expression of prostaglandin EP4 receptor in canine osteosarcoma     

Margaret L. Musser  Austin K. Viall  Rachel L. Phillips  Jesse M. Hostetter  Chad M. Johannes 《Canadian journal of veterinary research》2021,85(1):68

In many human cancers, the expression of the prostaglandin receptor EP4 (EP4R) is associated with the development of malignancy and a poor prognosis. The expression of EP4R has not yet been evaluated in canine tumors. The objective of this study was to characterize the messenger RNA (mRNA) expression of EP4R in canine osteosarcoma (OSA). Gene expression of EP4R was evaluated using RNA in-situ hybridization (RNAscope). In all canine OSA samples evaluated, strong universal positive expression of EP4R was identified. Gene expression was significantly higher in OSA tissue samples than in normal nasal turbinate bone, possibly implicating EP4R in the pathogenesis of canine OSA.  相似文献   

Carriage rate and antibiotic susceptibility of coagulase‐positive staphylococci isolated from healthy dogs in Victoria,Australia          下载免费PDF全文

DC Bean  SM Wigmore 《Australian veterinary journal》2016,94(12):456-460

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A framework for evaluation of on-farm mastitis diagnostics in Australia     

RN Zadoks  E Scholz  SM Rowe  JM Norris  HB Pooley  J House 《Australian veterinary journal》2023,101(4):142-152

Numerous culture-based diagnostics are available on the Australian and international markets for on-farm detection of bacterial pathogens in milk. Use of such diagnostics may provide an opportunity to improve the prudent use of antimicrobials in udder health management. Farms are low-resource settings in terms of diagnostic microbiology capacity. The World Health Organisation has identified criteria for the evaluation of diagnostic tests in low resource settings based on Accuracy, Sensitivity, Specificity, User-friendliness, being Rapid or Robust, Equipment-free and being Deliverable (ASSURED). Here, we review how those criteria can be interpreted in the context of microbiological diagnosis of mastitis pathogens, and how on-farm diagnostics that are currently available in Australia perform relative to ASSURED criteria. This evaluation identifies multiple trade-offs, both with regard to scientific criteria and with regards to convenience criteria. More importantly, the purpose of testing may differ between farms, and test performance should be evaluated relative to its intended use. The ability of on-farm mastitis diagnostics to inform mastitis treatment decision-making in a timely and cost-effective manner depends not just on test characteristics but also on farm-specific pathogen prevalence, and on the farm enterprise's priorities and the farm manager's potential courses of action. With most assay evaluations to date conducted in professional laboratories, there is a surprising dearth of information on how well any of the diagnostic tests perform on-farm and, indeed, of the on-farm decision-making processes that they aim to inform.  相似文献   

Plants as de-worming agents of livestock in the Nordic countries: historical perspective, popular beliefs and prospects for the future.     

PJ Waller  G Bernes  SM Thamsborg  A Sukura  SH Richter  K Ingebrigtsen  J H?glund 《Acta veterinaria Scandinavica》2001,42(1):31-44

Preparations derived from plants were the original therapeutic interventions used by man to control diseases (including parasites), both within humans and livestock. Development of herbal products depended upon local botanical flora with the result that different remedies tended to develop in different parts of the world. Nevertheless, in some instances, the same or related plants were used over wide geographic regions, which also was the result of communication and/or the importation of plant material of high repute. Thus, the Nordic countries have an ancient, rich and diverse history of plant derived anthelmintic medications for human and animal use. Although some of the more commonly used herbal de-wormers were derived from imported plants, or their products, many are from endemic plants or those that thrive in the Scandinavian environment. With the advent of the modern chemotherapeutic era, and the discovery, development and marketing of a seemingly unlimited variety of highly efficacious, safe synthetic chemicals with very wide spectra of activities, herbal remedies virtually disappeared from the consciousness--at least in the Western world. This attitude is now rapidly changing. There is a widespread resurgence in natural product medication, driven by major threats posed by multi-resistant pest, or disease, organisms and the diminishing public perceptions that synthetic chemicals are the panacea to health and disease control. This review attempts to provide a comprehensive account of the depth of historical Nordic information available on herbal de-wormers, with emphasis on livestock and to provide some insights on potentially rewarding areas of "re-discovery" and scientific evaluation in this field.  相似文献   

Are Endocrine Disrupting Compounds a Threat to Farm Animal Health,Welfare and Productivity?     

SM Rhind 《Reproduction in domestic animals》2005,40(4):282-290

Contents The sources and characteristics of endocrine disrupting compounds (EDCs) are reviewed and discussed with respect to their potential effects on farm animal health, welfare and productivity. The importance of certain properties of these compounds in relation to the expression of their biological effects is addressed together with potential routes of exposure. It is concluded that little is known of factors affecting the tissue concentrations of EDCs in farm animals, the concentrations that are required to perturb physiological function in these species, the effects of prolonged exposure to low doses, the effect of cocktails of EDCs and other pollutants or the responses of specific organs and physiological systems that are affected by EDCs. Much of the available information pertaining to EDCs is derived from epidemiological studies of wildlife species and from laboratory animal studies and while these studies have significant limitations, they are considered to be valuable indicators of potential effects in farm animal species. The results of such studies, together with the small amounts of data from studies of ruminants, indicate that there may be significant effects of exposure to environmental levels of EDCs on farm animal health, even although effects are not generally apparent in practice, at this time.  相似文献   

Effects of L-carnitine fed during lactation on sow and litter performance     

Musser RE  Goodband RD  Tokach MD  Owen KQ  Nelssen JL  Blum SA  Campbell RG  Smits R  Dritz SS  Civis CA 《Journal of animal science》1999,77(12):3296-3303

Sows of differing parities and genetics were used at different locations to determine the effects of feeding added L-carnitine during lactation on sow and litter performance. In Exp. 1, sows (n = 50 PIC C15) were fed a lactation diet (1.0% total lysine, .9% Ca, and .8% P) with or without 50 ppm of added L-carnitine from d 108 of gestation until weaning (d 21). No differences in litter weaning weight, survivability, sow ADFI, or sow weight and last rib fat depth change were observed. Number of pigs born alive in the subsequent farrowing were not different (P>.10). In Exp. 2, parity-three and -four sows (n = 115 Large White cross) were used to determine the effect of feeding 0, 50, 100, or 200 ppm of added L-carnitine during lactation (diet containing .9% total lysine, 1.0% Ca, and .8% P) on sow and litter performance. No improvements in the number of pigs or litter weights at weaning were observed (P>.10). Sows fed added L-carnitine had increased weight loss (linear; P<.04), but no differences (P>.10) were observed in last rib fat depth change or subsequent reproductive performance. In Exp. 3, first-parity sows (n = 107 PIC C15) were fed a diet with or without 50 ppm of added L-carnitine during lactation (diet containing 1.0% total lysine). Sows fed added L-carnitine tended (P<.10) to have fewer stillborn and mummified pigs than controls (.42 vs .81 pigs). No differences were observed for litter weaning weight, survivability, or subsequent farrowing performance. Feeding 50 to 200 ppm of added L-carnitine during lactation had little effect on sow and litter performance.  相似文献   

Added dietary pyridoxine, but not thiamin, improves weanling pig growth performance     

Woodworth JC  Goodband RD  Nelssen JL  Tokach MD  Musser RE 《Journal of animal science》2000,78(1):88-93

We conducted two trials to determine the effects of added dietary pyridoxine (vitamin B6) or thiamin (vitamin B1) on growth performance of weanling pigs. In Exp. 1, weanling pigs (n = 180, initially 5.55 +/- .84 kg, and 21 +/- 2 d of age) were fed either a control diet (no added pyridoxine or thiamin) or the control diet with added thiamin (2.8 or 5.5 mg/kg) from thiamin mononitrate or pyridoxine (3.9 or 7.7 mg/kg) from pyridoxine HC1. These five diets were fed in meal form in two phases (d0 to 14 and 14 to 35 after weaning), with identical vitamin concentrations in both phases. From d 0 to 14 after weaning, pigs fed added pyridoxine had increased (quadratic, P < .05) ADG and ADFI; pigs fed 3.9 mg/kg of added pyridoxine had the greatest improvement. From d 14 to 35 and 0 to 35, ADG and ADFI increased (linear P = .06) for pigs fed increasing pyridoxine. Growth performance was not improved by added thiamin. In Exp. 2, weanling pigs (n = 216, initially 6.08 +/- 1.13 kg, and 21 +/- 2 d of age) were fed a control diet or the control diet with 1.1, 2.2, 3.3, 4.4, or 5.5 mg/kg of added pyridoxine from pyridoxine HCl. From d 0 to 14 after weaning, increasing pyridoxine increased (quadratic, P < .05) ADG and ADFI; pigs fed 3.3 mg/kg of added pyridoxine had the greatest ADG and ADFI. Break-point analysis suggested a requirement estimate of 3.3 and 3.0 mg/kg of added pyridoxine to maximize ADG and ADFI, respectively. From d 14 to 35 or 0 to 35, increasing pyridoxine had no effect (P > .10) on pig growth performance. These results suggest that adding 3.3 mg/kg of pyridoxine (7.1 to 7.9 mg/kg of total pyridoxine) to diets fed from d 0 to 14 after weaning can improve pig growth performance.  相似文献   

A CONSIDERATION OF THE CLINICAL AND DIDACTIC METHODS OF TEACHING MEDICINE     

Musser JH 《Science (New York, N.Y.)》1925,61(1591):641-644

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Comparative Expression Analysis of Gametogenesis‐Associated Genes in Foetal and Adult Bubaline (Bubalus bubalis) Ovaries and Testes          下载免费PDF全文

SM Shah  N Saini  S Ashraf  M Zandi  MK Singh  RS Manik  SK Singla  P Palta  MS Chauhan 《Reproduction in domestic animals》2015,50(3):365-377

This study was conducted to identify and analyse the expression of gametogenesis‐associated genes and proteins in foetal and adult buffalo gonads of both the sexes. Relative quantification of the genes was determined by qPCR and Western blotting. Immunohistochemistry was also performed for various gametogenesis‐associated proteins in foetal and adult gonads of both the sexes. We observed significantly (p < 0.05) increased expression of primordial germ cell‐specific, meiotic as well as genes associated with oocyte maturation and development in foetal ovaries as compared to the adult ones. However, significantly (p < 0.05) increased expression of proteins associated with oocyte maturation like GDF9 and ZP4 was found in adult ovaries, indicating temporal regulation of mRNA translation during oogenesis. Meiotic genes showed significantly (p < 0.05) increased expression in adult testes as compared to foetal testes and ovaries, indicating onset of meiosis at a later stage in spermatogenesis. In general, the expression of primordial germ cell‐associated as well as meiotic genes was higher in adult testes, indicating the increased biological activity in the organ. Immunohistochemistry revealed localized expression of gametogenesis‐associated proteins in ovarian follicles and seminiferous tubules of testes, while the surrounding somatic tissues were devoid of these proteins. The study gives an understanding of the sequential and temporal events of gene expression as well as mRNA translation during male and female gametogenesis. It could also be concluded that follicles and seminiferous tubules are the functional units of the female and male gonads, respectively, and their function could be enhanced by appropriate chemical and genetic intervention of the somatic tissue immediately surrounding them. This assumes importance in the context that buffalo attains sexual maturity at an older age of 2–3 years and have smaller ovaries with lesser number of primordial follicles in comparison with cattle, which is suggested to be the main reason of their poor breeding performance.  相似文献