Rapid communication: Mapping of the pro-opiomelanocortin (POMC) gene to pig chromosome by linkage analysis using a PCR-RFLP     

Messer LA  Cargill EJ  Pomp D 《Journal of animal science》2001,79(8):2241-2242

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A multicenter, matched case-control study of risk factors for equine laminitis     

Alford P  Geller S  Richrdson B  Slater M  Honnas C  Foreman J  Robinson J  Messer M  Roberts M  Goble D  Hood D  Chaffin M 《Preventive veterinary medicine》2001,49(3-4):209-222

Risk factors for equine laminitis were examined in a prospective case-control study of the 258 cases seen at six collaborating veterinary teaching hospitals over a 32-month period. Case-control pairs were matched on institution, clinician, and season of diagnosis. The 90% of case-control pairs (78 acute, 155 chronic) that had complete data for age, gender, and breed were used in separate conditional logistic-regression models for acute and chronic laminitis. There was an increase in risk for horses with acute laminitis from 5 to 7 years of age (OR 4.7, 95% CI 1.3–16) and from 13 to 31 years of age (OR 3.9, 95% CI 1.3–12) (both compared to <5 years); risk was increased for chronic laminitis from 10 to 14 years (OR 3, 95% CI 1.4–6.8) and from 15 to 38 years (OR 2.9, 95% CI 1.4–6.1) (both compared to <6 years). Mares — but not stallions — were more likely than geldings to develop acute laminitis (OR 2.6, 95% CI 1.1–6.2) and chronic laminitis (OR 2.0, 95% CI 1.1–3.6). In the small acute-laminitis data set, the breed variable was collapsed into three categories: Thoroughbred (THB, reference), the Quarter Horse (QH), and other (non-QH-THB). The non-QH-THB group was at increased risk of acute laminitis (OR 3.8, 95% CI 1.2–11.8). For the seven breed-group categories used in the chronic-laminitis model, however, all non-THB breed groups appeared significantly at risk as compared to the THB, with odds ratios ranging from 3.3 (95% CI 1.3–8.30) for the QH to 9.1 (95% CI 2.1–39.3) for ponies.  相似文献   

The Veterinary Society of Fribourg and Martin Strebel     

Messer M 《Schweizer Archiv für Tierheilkunde》2003,145(1):17-20

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Equine thyroid dysfunction.     

Nicholas Frank  Janice Sojka  Nat T Messer 《Veterinary Clinics of North America: Equine Practice》2002,18(2):305-19, vii

Hypothyroidism is the most common type of thyroid gland dysfunction reported in horses. Primary, secondary, and tertiary causes of hypothyroidism are discussed. Equine hypothyroidism remains a controversial endocrine disorder because extrathyroidal factors, including the administration of drugs and systemic diseases, affect serum triiodothyronine (T3) and thyroxine (T3) concentrations in horses. Accurate diagnosis of hypothyroidism therefore requires assessment of the hypothalamic-pituitary-thyroid axis. Diagnostic procedures for evaluating thyroid gland function are outlined and results of studies utilizing experimental models are discussed.  相似文献   

Energetics of hydrogen bond network rearrangements in liquid water     

Smith JD  Cappa CD  Wilson KR  Messer BM  Cohen RC  Saykally RJ 《Science (New York, N.Y.)》2004,306(5697):851-853

A strong temperature dependence of oxygen K-edge x-ray absorption fine structure features was observed for supercooled and normal liquid water droplets prepared from the breakup of a liquid microjet. Analysis of the data over the temperature range 251 to 288 kelvin (-22 degrees to +15 degrees C) yields a value of 1.5 +/- 0.5 kilocalories per mole for the average thermal energy required to effect an observable rearrangement between the fully coordinated ("ice-like") and distorted ("broken-donor") local hydrogen-bonding configurations responsible for the pre-edge and post-edge features, respectively. This energy equals the latent heat of melting of ice with hexagonal symmetry (ice Ih) and is consistent with the distribution of hydrogen bond strengths obtained for the "overstructured" ST2 model of water.  相似文献   

Use of ev loci as a measure of inbreeding in domestic fowls     

N Bumstead  L I Messer  N G Greenwood 《British poultry science》1987,28(4):717-725

1. The endogenous avian leukosis virus (ev) loci present in 9 lines of domestic fowls have been partially characterised and the average heterozygosity of the loci in each line calculated. 2. Using these data an estimate of the coefficient of inbreeding of the lines was derived; this estimate of the extent of inbreeding is compared with the mating history of the lines. 3. This method provides the first means of directly assessing the degree of inbreeding of fowl lines: assumptions implicit in the method are discussed.  相似文献   

Diabetes mellitus in a domesticated Spanish mustang     

Johnson PJ  Scotty NC  Wiedmeyer C  Messer NT  Kreeger JM 《Journal of the American Veterinary Medical Association》2005,226(4):584-8, 542

An 18-year-old Spanish Mustang mare was referred for evaluation of progressive weight loss and persistent hyperglycemia. Clinicopathologic abnormalities included marked hyperglycemia and glycosuria. Serum cortisol concentration was appropriately decreased following administration of dexamethasone, indicating that the horse did not have pituitary pars intermedia dysfunction. Serum insulin and plasma C-peptide concentrations were low, suggesting that hyperglycemia was a result of decreased secretion of insulin by pancreatic beta cells. In addition, glucose concentration did not return to the baseline concentration until 5 hours after i.v. administration of a glucose bolus, suggesting that insulin secretion, insulin effect, or both were reduced. However, i.v. administration of insulin caused only a slight decrease in the plasma glucose concentration, giving the impression that the action of insulin was impaired. Within 5 hours after administration of a combination of glyburide and metformin, which is used to treat diabetes mellitus in humans, the glucose concentration was within reference limits. The horse was euthanized, and a postmortem examination was done. Immunohistochemical staining of sections of the pancreas revealed attenuation of the pancreatic islet beta-cell population, with beta cells that remained generally limited to the periphery of the islets. These findings indicate that, albeit rare, pancreatic beta-cell failure may contribute to the development of diabetes mellitus in horses.  相似文献   

What is your diagnosis? Actinobacillus pleuropneumonia     

N Tobler  DM Fine  NT Messer  PJ Johnson 《Journal of the American Veterinary Medical Association》2012,241(3):315-317

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Assessment of insecticidal effects and selectivity of CAPA‐PK peptide analogues against the peach‐potato aphid and four beneficial insects following topical exposure     

Shun‐Hua Gui  Clauvis NT Taning  Kristof De Schutter  Qun Yang  Pengyu Chen  Mohamad Hamshou  Ronald J Nachman  Aniruddha A Pandit  Julian AT Dow  Shireen Davies  Guy Smagghe 《Pest management science》2020,76(10):3451-3458

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Laminitis and the Equine Metabolic Syndrome     

Philip J. Johnson  Charles E. Wiedmeyer  Alison LaCarrubba  V.K. Ganjam  Nat T. Messer IV 《Veterinary Clinics of North America: Equine Practice》2010

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