Single step genomic evaluation for female fertility in Nordic Red dairy cattle          下载免费PDF全文

Kaarina Matilainen  Ismo Strandén  Gert Pedersen Aamand  Esa A. Mäntysaari 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2018,135(5):337-348

Joint Nordic (Denmark, Finland, Sweden) genetic evaluation of female fertility is currently based on the multiple trait multilactation animal model (BLUP). Here, single step genomic model (ssGBLUP) was applied for the Nordic Red dairy cattle fertility evaluation. The 11 traits comprised of nonreturn rate and days from first to last insemination in heifers and first three parities, and days from calving to first insemination in the first three parities. Traits had low heritabilities (0.015–0.04), but moderately high genetic correlations between the parities (0.60–0.88). Phenotypic data included 4,226,715 animals with records and pedigree 5,445,392 animals. Unknown parents were assigned into 332 phantom parent groups (PPG). In mixed model equations animals were associated with PPG effects through the pedigree or both the pedigree and genomic information. Genotype information of 46,914 SNPs was available for 33,969 animals in the pedigree. When PPG used pedigree information only, BLUP converged after 2,420 iterations whereas the ssGBLUP evaluation needed over ten thousand iterations. When the PPG effects were solved accounting both the pedigree and the genomic information, the ssGBLUP model converged after 2,406 iterations. Also, with the latter model breeding values by ssGBLUP and BLUP became more consistent and genetic trends followed each other well. Models were validated using forward prediction of the young bulls. Reliabilities and variance inflation of predicted genomic breeding values (values for parent averages in brackets) for the 11 traits ranged 0.22–0.31 (0.10–0.27) and 0.81–0.95 (0.83–1.06), respectively. The ssGBLUP model gave always higher validation reliabilities than BLUP, but largest increases were for the cow fertility traits.  相似文献   

Spontaneous femoral capital physeal fractures in adult cats: 26 cases (1996-2001)     

McNicholas WT  Wilkens BE  Blevins WE  Snyder PW  McCabe GP  Applewhite AA  Laverty PH  Breur GJ 《Journal of the American Veterinary Medical Association》2002,221(12):1731-1736

OBJECTIVE: To determine clinical, radiographic, and histologic abnormalities in adult cats > 1 year old with spontaneous (ie, nontraumatic) femoral capital physeal fractures. DESIGN: Retrospective study. ANIMALS: 26 cats. PROCEDURE: Medical records of cats > 1 year old with femoral capital physeal fractures and no history of trauma were examined. RESULTS: Mean +/- SD age of the cats was 22.5 +/- 6.5 months. Twenty-five cats were neutered males. Mean weight of the cats was significantly greater than mean weight of a group of age- and sex-matched control cats. Of 16 cats for which age at the time of neutering was known, 14 had been neutered before 6 months of age. Nine cats had bilateral fractures. Severity of femoral neck osteolysis and sclerosis increased with increased duration of clinical signs. The contralateral femoral capital physis, distal femoral physes, and proximal tibial physes were radiographically open in 13 of 18,19 of 24, and 24 of 24 cats, respectively. Histologically, the epiphysis contained normal articular cartilage and bone, but attached growth plate cartilage lacked the normal columnar arrangement of chondrocytes. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that adult cats with spontaneous femoral capital physeal fractures were most likely to be heavier, neutered males with delayed physeal closure.  相似文献   

Neuroendocrine-immune interactions in fish: a role for interleukin-1   总被引：10，自引：0，他引：10  

Engelsma MY  Huising MO  van Muiswinkel WB  Flik G  Kwang J  Savelkoul HF  Verburg-van Kemenade BM 《Veterinary immunology and immunopathology》2002,87(3-4):467-479

Bi-directional communication between the hypothalamus-pituitary-adrenal (HPA)-axis and the sympathetic nervous system with the immune system is crucial to ensure homeostasis. Shared use of ligands and especially receptors forms a key component of this bi-directional interaction. Glucocorticoids (GC), the major end products of the HPA-axis differentially modulate immune function. Cytokines, especially interleukin-1 (IL-1), tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), ensure immune signalling to the neuroendocrine system. In addition, hormones from leukocyte origin such as corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and beta-endorphin, as well as centrally synthesised and secreted cytokines, contribute to the communication network.In teleost fish cortisol is the major product of the hypothalamus-pituitary-interrenal (HPI)-axis which is the teleost equivalent of the HPA-axis. Moderate and substantial increases in cortisol during stressful circumstances negatively affect B-lymphocytes, whereas rescue of neutrophilic granulocytes may support innate immunity. Recent elucidation of lower vertebrate cytokine sequences has facilitated research into neuroendocrine-immune interactions in teleosts and the first evidence for a significant function of interleukin-1 in the bi-directional communication is discussed.  相似文献   

Erratum to: Physiological and behavioral responses to an electrical stimulus in Mozambique tilapia (Oreochromis mossambicus)     

Jonathan A. C. Roques  Wout Abbink  Gaétan Chereau  Aurélie Fourneyron  Tom Spanings  Dirk Burggraaf  Ruud van den Bos  Hans van de Vis  Gert Flik 《Fish physiology and biochemistry》2012,38(6):1855-1855

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Combined Rostrolateral Rhinotomy for Removal of Rostral Nasal Septum Squamous Cell Carcinoma: Long‐Term Outcome in 10 Dogs          下载免费PDF全文

Gert Ter Haar DVM  PhD  Diplomate ECVS  Rachel Hampel BSc  BVSc 《Veterinary surgery : VS》2015,44(7):843-851

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Detection of ruminant meat and bone meals in animal feed by real-time polymerase chain reaction: result of an interlaboratory study   总被引：1，自引：0，他引：1  

Prado M  Berben G  Fumière O  van Duijn G  Mensinga-Kruize J  Reaney S  Boix A  von Holst C 《Journal of agricultural and food chemistry》2007,55(18):7495-7501

The commercialization of animal feeds infected by prions proved to be the main cause of transmission of bovine spongiform encephalopathy (BSE). Therefore, feed bans were enforced, initially for ruminant feeds, and later for all feeds for farmed animals. The development and validation of analytical methods for the species-specific detection of animal proteins in animal feed has been indicated in the TSE (Transmissible Spongiform Encephalopathies) Roadmap (European Commission. The TSE (Transmissible Spongiform Encephalopathy) roadmap. URL: http://europa.eu.int/comm/food/food/biosafety/bse/roadmap_en.pdf, 2005) as the main condition for lifting the extended feed ban. Methods based on polymerase chain reaction (PCR) seem to be a promising solution for this aim. The main objective of this study was to determine the applicability of four different real-time PCR methods, developed by three National expert laboratories from the European Union (EU), for the detection and identification of cattle or ruminant species in typical compound feeds, fortified with meat and bone meals (MBM) from different animal species at different concentration levels. The MBM samples utilized in this study have been treated using the sterilization condition mandatory within the European Union (steam pressure sterilization at 133 degrees C, 3 bar, and 20 min), which is an additional challenge to the PCR methods evaluated in this study. The results indicate that the three labs applying their PCR methods were able to detect 0.1% of cattle MBM, either alone or in mixtures with different materials such as fishmeal, which demonstrates the improvement made by this technique, especially when compared with results from former interlaboratory studies.  相似文献   

Confirmation of spatial patterns and temperature effects in Bluetongue virus serotype-8 transmission in NW-Europe from the 2007 reported case data     

Gert Jan Boender  Thomas J Hagenaars  Armin RW Elbers  J?rn M Gethmann  Estelle Meroc  Helene Guis  Aline A de Koeijer 《Veterinary research》2014,45(1)

Two separate analyses were carried out to understand the epidemiology of Bluetongue virus serotype 8 (BTV-8) in 2007 in North West Europe: First, the temporal change in transmission rates was compared to the evolution of temperature during that season. Second, we evaluated the spatio-temporal dynamics of newly reported outbreaks, to estimate a spatial transmission kernel. For both analyses, the approach as used before in analysing the 2006 BTV-8 epidemic had to be adapted in order to take into account the fact that the 2007 epidemic was not a newly arising epidemic, but one advancing from whereto it had already spread in 2006. We found that within the area already affected by the 2006 outbreak, the pattern of newly infected farms in 2007 cannot be explained by between-farm transmission, but rather by local re-emergence of the virus throughout that region. This indicates that persistence through winter was ubiquitous for BTV-8. Just like in 2006, we also found that the temperature at which the infection starts to spread lies close to 15 °C. Finally, we found that the shape of the transmission kernel is in line with the one from the 2006 epidemic. In conclusion, despite the substantial differences between 2006 and 2007 in temperature patterns (2006 featured a heat wave in July, whereas 2007 was more regular) and spatial epidemic extent, both the minimum temperature required for transmission and the transmission kernel were similar to those estimated for the 2006 outbreak, indicating that they are robust properties, suitable for extrapolation to other years and similar regions.  相似文献   

Calcium currents and exocytosis in single isolated pars intermedia cells from tilapia (Oreochromis mossambicus)     

Th.J.M. Schoenmakers  G. Flik  E.W. Roubos  S.E. Wendelaar Bonga 《Fish physiology and biochemistry》1997,17(1-6):347-355

The role of calcium influx through voltage-dependent calcium ion channels in the exocytotic response of single isolated pars intermedia cells from the teleost tilapia (Oreochromis mossambicus) was investigated by means of the whole-cell patch-clamp technique and high resolution electrical measurements. Calcium currents differed from barium currents in several ways: the peak I_Ca was smaller, the current-voltage relationship for calcium attained its maximum at +10 mV instead of 0 mV, and the inward calcium current inactivated more rapidly. Electron micrographs showed that pars intermedia cells possess dense, encored vesicles with an average diameter of 140 nm. Influx of calcium resulted in an increased cell membrane capacitance (C_m) after the depolarizing period, indicating a fast exocytotic response. Comparison with late recordings revealed the presence of a transient in C_m, presumably attributable to movement of ion channel gates. The average increase in C_m was 13.4 fF, suggesting the fusion of at least 23 vesicles with the plasma membrane during the depolarizing pulse. In contrast to calcium, barium did not support significant exocytosis. We conclude that calcium entry through voltage-dependent calcium channels rapidly leads to the exocytosis of secretory vesicles from tilapia pars intermedia cells.  相似文献   

Marennine,Promising Blue Pigments from a Widespread Haslea Diatom Species Complex     

Romain Gastineau  Fran?ois Turcotte  Jean-Bernard Pouvreau  Michèle Moran?ais  Jo?l Fleurence  Eko Windarto  Fiddy Semba Prasetiya  Sulastri Arsad  Pascal Jaouen  Mathieu Babin  Laurence Coiffard  Céline Couteau  Jean-Fran?ois Bardeau  Boris Jacquette  Vincent Leignel  Yann Hardivillier  Isabelle Marcotte  Nathalie Bourgougnon  Réjean Tremblay  Jean-Sébastien Deschênes  Hope Badawy  Pamela Pasetto  Nikolai Davidovich  Gert Hansen  Jens Dittmer  Jean-Luc Mouget 《Marine drugs》2014,12(6):3161-3189

In diatoms, the main photosynthetic pigments are chlorophylls a and c, fucoxanthin, diadinoxanthin and diatoxanthin. The marine pennate diatom Haslea ostrearia has long been known for producing, in addition to these generic pigments, a water-soluble blue pigment, marennine. This pigment, responsible for the greening of oysters in western France, presents different biological activities: allelopathic, antioxidant, antibacterial, antiviral, and growth-inhibiting. A method to extract and purify marennine has been developed, but its chemical structure could hitherto not be resolved. For decades, H. ostrearia was the only organism known to produce marennine, and can be found worldwide. Our knowledge about H. ostrearia-like diatom biodiversity has recently been extended with the discovery of several new species of blue diatoms, the recently described H. karadagensis, H. silbo sp. inedit. and H. provincialis sp. inedit. These blue diatoms produce different marennine-like pigments, which belong to the same chemical family and present similar biological activities. Aside from being a potential source of natural blue pigments, H. ostrearia-like diatoms thus present a commercial potential for aquaculture, cosmetics, food and health industries.  相似文献   

Dietary behaviour of German adults differing in levels of sport activity     

Beitz R  Mensink GB  Henschel Y  Fischer B  Erbersdobler HF 《Public health nutrition》2004,7(1):45-52

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