Chronic diarrhea associated with intestinal anomalies in a six-year-old dog.     

E Zenger  W N Evering  M D Willard 《Journal of the American Veterinary Medical Association》1992,201(11):1737-1740

A 6-year-old mixed-breed dog was referred because of chronic diarrhea, which had begun after antibiotic treatment for pulmonary disease. Intestinal bacterial overgrowth was presumptively diagnosed on the basis of intestinal mucosal cytologic examination and low serum cobalamin concentration. When the diarrhea did not respond to treatment, contrast radiography was performed and a short small intestine was found. The diarrhea could not be managed by medical treatment, and the dog was euthanatized. Necropsy revealed 2 blind intestinal pouches attached to a 46-cm length of small intestine connecting the stomach and colon. The dog's deteriorating condition was attributable to necrosis and rupture of 1 of the pouches.  相似文献   

Efficacy of famotidine for the prevention of exercise-induced gastritis in racing Alaskan sled dogs     

Williamson KK  Willard MD  McKenzie EC  Royer CM  Payton ME  Davis MS 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2007,21(5):924-927

BACKGROUND: Omeprazole reduces the severity of exercise-induced gastritis but not the prevalence of gastric lesions in sled dogs. The frequent feeding of sled dogs during competition likely results in decreased absorption of omeprazole and, thereby, decreased efficacy. HYPOTHESIS: Famotidine, a histamine-2 blocker with good bioavailability in the presence of food, would reduce the incidence and severity of exercise-induced gastric disease in sled dogs. ANIMALS: Sixteen fit Alaskan sled dogs (4 female, 12 male, all intact, age 2-6 years). METHODS: Dogs were randomly assigned to treatment (22 mg famotidine PO q24h) or control groups (n = 8 per group). Famotidine was administered with a meal to the treatment group once daily for 7 days before a challenge and once during exercise. Control dogs were fed an identical diet as the principal group. The 16 dog team completed a 100-mile exercise challenge in 18 hours. A gastroscopy was performed 24 hours after the challenge. The appearance of the mucosa was scored by an individual by using a scoring system. RESULTS: Treatment with famotidine significantly reduced the severity score compared with control (P = .0004). No adverse effects of treatment were reported. CONCLUSIONS AND CLINICAL RELEVANCE: Famotidine is effective in reducing the severity of exercise-induced gastric disease in racing Alaskan sled dogs, with minimal to no adverse effects, and may be recommended for prophylactic use in short distance races.  相似文献   

Quality of tissue specimens obtained endoscopically from the duodenum of dogs and cats     

Willard MD  Lovering SL  Cohen ND  Weeks BR 《Journal of the American Veterinary Medical Association》2001,219(4):474-479

OBJECTIVE: To evaluate quality of duodenal tissue specimens obtained endoscopically from dogs and cats and submitted to 1 of 2 diagnostic laboratories for evaluation. DESIGN: Case series. SAMPLE POPULATION: Slides from 50 consecutive canine and 50 consecutive feline endoscopically obtained duodenal tissue specimens submitted to laboratory 1 and 49 consecutive canine and 46 consecutive feline specimens submitted to laboratory 2. PROCEDURE: Slides were examined independently by 3 investigators, and each tissue piece on each slide was classified as clearly inadequate, questionable, or clearly adequate on the basis of 4 criteria. An overall score was then assigned to the slide. RESULTS: Slides from laboratory 1 were more likely to be scored as clearly adequate and less likely to be scored as clearly inadequate than slides from laboratory 2. Clearly adequate slides from laboratory 1 had a higher number of clearly adequate pieces of tissue than did clearly adequate slides from laboratory 2. Slides scored as clearly adequate had a higher number of individual tissue pieces than did slides scored as clearly inadequate. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that the quality of endoscopically obtained duodenal tissue specimens submitted to laboratories can vary, possibly because of differences in experience of individuals collecting biopsy specimens. Results suggest that at least 8 individual tissue pieces should be submitted when performing endoscopic biopsy of the duodenum in dogs and cats.  相似文献   

Prevalence of gastric lesions in racing Alaskan sled dogs     

Davis MS  Willard MD  Nelson SL  Mandsager RE  McKiernan BS  Mansell JK  Lehenbauer TW 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2003,17(3):311-314

Human and equine athletes are reported to have a high prevalence of gastric disease, and anecdotal evidence suggests a similar phenomenon applies to racing sled dogs. To investigate the prevalence of gastric disease in racing sled dogs, we conducted 2 gastroscopy studies on dogs competing in the annual Iditarod Sled Dog Race. A pilot study of dogs that were either dropped from the 2000 Iditarod Sled Dog Race because of illness or that finished the race indicated that, approximately 5 days after competing, 10 of 28 dogs (35%) had endoscopic evidence of gastric ulceration, erosion, or hemorrhage. The next year, an endoscopic study of 73 dogs participating in the 2001 Iditarod race was performed in order to evaluate a larger population of dogs. Data from 70 of these dogs could be used; 34 (48.5%) had ulceration, erosion, gastric hemorrhage, or some combination of these findings. When this group of 70 dogs was compared retrospectively to a control group of 87 dogs presented to the Texas A&M University (TAMU) Veterinary Medical Teaching Hospital, the Iditarod sled dogs had a significantly higher prevalence (P = .049) of gastric lesions. These findings suggest that, similar to athletes of other species, elite canine athletes have an increased prevalence of gastric disease compared to the canine population at large.  相似文献   

Protein-losing enteropathy associated with cystic mucoid changes in the intestinal crypts of two dogs     

Willard MD  Zenger E  Mansell JL 《Journal of the American Animal Hospital Association》2003,39(2):187-191

Two dogs were emaciated and hypoalbuminemic due to protein-losing enteropathy associated with a severe, focal, mucoid, cryptal ectasia of the duodenum and marked villus atrophy. In one case, diseased portions of the duodenum were obvious endoscopically and were limited to discrete, focal areas in the small intestine, with apparently more undiseased tissue than diseased tissue being present. The signs and lesions in one dog resolved after initiating combination dietary and pharmacological therapy.  相似文献   

FIELD CONFERENCE OF PENNSYLVANIA GEOLOGISTS     

Willard B 《Science (New York, N.Y.)》1933,77(2009):629-630

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Newer concepts in treatment of secretory diarrheas   总被引：1，自引：0，他引：1  

M D Willard 《Journal of the American Veterinary Medical Association》1985,186(1):86-88

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Toxoplasmosis in two cats with inflammatory intestinal disease   总被引：1，自引：0，他引：1  

J L Peterson  M D Willard  G E Lees  M R Lappin  T Dieringer  E Floyd 《Journal of the American Veterinary Medical Association》1991,199(4):473-476

Lymphocytic-plasmacytic enteritis, a chronic inflammatory intestinal disease, was diagnosed in 2 cats. In 1 cat, recurrence of clinical signs after initiating treatment was attributed to relapse of the inflammatory intestinal disease, but was found to be attributable to relapsing toxoplasmosis secondary to immunosuppressive drug therapy. Treatment with clindamycin resolved the recurrent toxoplasmosis. In the second cat, clinical signs of toxoplasmosis did not develop, but serologic testing yielded evidence of active toxoplasmosis. Treatment with clindamycin caused the titers to decrease. Relapsing toxoplasmosis may be responsible for apparent resistance to treatment in cats for inflammatory intestinal disease being treated with immunosuppressive drugs.  相似文献   

Panfibrinonecrotic colitis in a dog treated by subtotal colectomy     

J Dvorak  M D Willard  E Floyd 《Journal of the American Veterinary Medical Association》1991,198(2):264-266

A dog with signs of small intestinal disease developed signs of severe large intestinal disease after being treated with multiple agents. Endoscopy and biopsy revealed total destruction of the colonic mucosa, which necessitated total parenteral nutrition plus subtotal colectomy. It was hypothesized that the multiple prior treatments led to an overgrowth of toxigenic or cytotoxic bacteria, which caused this colonic mucosal destruction.  相似文献   

An analysis of age and body weight at first calving for Holsteins in the United States     

Willard C. Losinger  A. Jud Heinrichs 《Preventive veterinary medicine》1997,32(3-4):193-205

In a national survey of US dairy producers, only 2.7 ± 0.5% of Holstein dairy operations reported achieving recommended target ranges of age ≤ 24 months and body weight (BW) ≥ 550 kg at first calving. Allowing for wider target ranges, still only 14.6 ± 1.3% of Holstein dairy operations reported achieving age ≤ 25 months and BW ≥ 544.3 kg at first calving. Ages of individual first-calf heifers observed at calving were heavily skewed toward older individuals. Dairy producers reported an average age at first calving that was 1.3 months lower than the mean and 1.0 months lower than median age of first-calf heifers' observed calving on the operations. Stepwise logistic regression was used to identify the herd characteristics associated with producers reporting first calvings within the wider age and BW target ranges for Holsteins. Rolling herd average milk production ≥ 7711 kg/yr, using a computer for recordkeeping, and not tying preweaned heifers in a barn with cows, were associated with achieving the target BW and age at first calving.  相似文献